Realtime 3D MRI Technologies for Therapy and Diagnosis

用于治疗和诊断的实时 3D MRI 技术

• 批准号: 7919110
• 负责人: WALTER F BLOCK
• 金额: $ 14.56万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919110
• 关键词: Aging; Algorithms; Anatomy; Angiography; Blood Vessels; Cancer Patient; Catheterization; Catheters; Cause of Death; Chemoembolization; Clinical; Computer Systems; Computers; Data; Development; Diagnosis; Diagnostic; Digital Subtraction Angiography; Digital X-Ray; Dimensions; Discipline of Nuclear Medicine; Distal; Dose; Drug Delivery Systems; Effectiveness; Europe; Excision; Foundations; Gases; Gene Delivery; Hepatic artery; Human; Hypervascular; Image; Imagery; Incidence; Injection of therapeutic agent; Ionizing radiation; Laboratories; Lesion; Link; Liver; Liver diseases; Liver neoplasms; Location; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Metastatic Neoplasm to the Liver; Methods; Operative Surgical Procedures; Outcome; Pain; Patients; Pharmaceutical Preparations; Physiologic pulse; Primary carcinoma of the liver cells; Procedures; Process; Quality of life; Radiation therapy; Rectal Cancer; Relative (related person); Renal function; Research Personnel; Resolution; Resources; Roentgen Rays; Sampling; Scanning; Speed; Structure; System; Techniques; Technology; Testing; Therapeutic; Thick; Three-Dimensional Imaging; Time; Tissues; Ultrasonography; Universities; Vertebral column; Weight; Wisconsin; chemotherapy; design; digital; experience; imaging modality; improved; reconstruction; skills; targeted delivery; treatment planning; tumor

DESCRIPTION (provided by applicant): The quality of life and survival for cancer patients are considerably threatened by liver metastases. While surgical resection is often not possible and systemic chemotherapy is largely ineffective, promising interventional therapeutic techniques are available. The focus of this project is to demonstrate the effectiveness of real-time time-resolved 3D MR guidance for one such technique: transcatheter arterial chemoembolization (TACE). Successful completion of the project will not only allow immediate improvement of TACE procedure, but should prove to be a capable foundation for other drug delivery techniques where fusing information of local vasculature and anatomy is beneficial. Current guidance for TACE from X-ray Digital Subtraction Angiography( DSA) provides thick 2D projection images with little information on tumor location while increasing the already high dose of ionizing radiation received by liver tumor patients. While MR imaging has provided 3D capabilities for some time, further improvements in acquisition speed, reconstruction processing, and visualization are necessary to apply real-time 3D MRI to new problems. Challenges are derived from the extraordinary increase in data created by 4D imaging. But opportunities are derived from the rapid development of parallel imaging in MRI, new paradigms for using MR's multiple contrast mechanisms, and the continued dramatic improvement in computing power. This project aims to develop 4D MRI, three spatial dimensions plus time, to better visualize the structure and significance of the vasculature adjacent to tumors, and integrate it with the other interventional imaging methods necessary for TACE. Specifically, the first two specific aims of this project concentrate on reconstruction and visualization: 1) Improve MR imaging speed and coverage using faster, more efficient non-Cartesian techniques and integrating these into a real-time reconstruction platform and 2) visualizing of 4D data using a computer cluster. The third aim integrates these developments with other capabilities necessary for MR guidance including catheter visualization and 3D T2-weighted imaging for lesion conspicuity. The last aim verifies these capabilities using the same methods used to validate clinical TACE. Successful completion will provide the necessary information to support a later human trial and a platform for guiding TACE as well as drug delivery in general. Outcomes for the first two aims will also shorten acquisition time, improve image quality, and simplify interpretation of time-resolved diagnostic MR angiography.

描述（由申请人提供）：癌症患者的生活质量和生存率受到肝转移的严重威胁。虽然手术切除往往是不可能的，全身化疗在很大程度上是无效的，有前途的介入治疗技术是可用的。该项目的重点是证明实时时间分辨3D MR引导用于经导管动脉化疗栓塞术（TACE）的有效性。该项目的成功完成不仅可以立即改善TACE手术，而且应该被证明是其他药物输送技术的基础，其中融合局部血管和解剖结构的信息是有益的。目前，来自X射线数字减影血管造影术（DSA）的TACE引导提供了厚的2D投影图像，几乎没有关于肿瘤位置的信息，同时增加了肝脏肿瘤患者接受的已经很高的电离辐射剂量。虽然MR成像提供3D功能已经有一段时间了，但需要进一步改进采集速度、重建处理和可视化，以将实时3D MRI应用于新问题。挑战来自于4D成像所创建的数据的非凡增长。但机会来自于MRI并行成像的快速发展，使用MR多重对比机制的新范例，以及计算能力的持续显著提高。该项目旨在开发三维MRI，三维空间加时间，以更好地可视化肿瘤附近血管的结构和意义，并将其与TACE所需的其他介入成像方法相结合。具体而言，该项目的前两个具体目标集中在重建和可视化上：1）使用更快，更有效的非笛卡尔技术提高MR成像速度和覆盖范围，并将其集成到实时重建平台中，2）使用计算机集群可视化4D数据。第三个目标是将这些发展与MR引导所需的其他功能相结合，包括导管可视化和3D T2加权成像以显示病变。最后一个目的是使用与确认临床TACE相同的方法来验证这些能力。成功完成将提供必要的信息，以支持以后的人体试验和指导TACE以及一般药物输送的平台。前两个目标的结果也将缩短采集时间，提高图像质量，并简化时间分辨诊断MR血管造影的解释。