Units for HIV/AIDS Clinical Trials Networks

描述（由申请人提供）：芝加哥临床治疗中心（CTU）计划参加国际母婴青少年艾滋病临床试验（IMPAACT）网络提出的临床研究。我们的目标是参与基于假设和病因导向的试验方案，旨在1)提高阻断艾滋病毒母婴传播的能力；2)改善美国和国际上针对儿童和青少年的预防和治疗干预措施；3)评估艾滋病毒感染儿童、青少年和孕妇的合并感染和合并发病的治疗和预防；4)评估预防艾滋病毒的疫苗，或增强感染艾滋病毒的儿童和青少年的免疫系统。拟议中的芝加哥CTU的四个单位位于世界不同的地方。在芝加哥，芝加哥临床研究中心（CRS）的广泛集水区及其与许多社区机构建立的联系将使我们能够有效地接触到芝加哥及周边地区已知受艾滋病毒流行影响的许多儿童、青少年和妇女。

DESCRIPTION (provided by applicant): The Chicago Clinical Treatment Unit (CTU) plans to participate in the clinical research proposed by the International Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT) network. Our goal is to participate in protocols that are hypothesis-based and pathogenesis-oriented trials designed to 1) advance the ability to interrupt mother-to-child transmission of HIV; 2) improve prevention and treatment interventions for children and adolescents in the United State and internationally; 3) evaluate treatments and prevention of co-infections and co-morbidities in HIV-infected children, adolescents and pregnant women; 4) evaluate vaccines for the prevention of HIV, or to boost the immune system of HIV-infected children and adolescents. The proposed four units of the Chicago CTU are located in different parts of the world. In Chicago, the wide-range catchment area of the Chicago Clinical Research Sites (CRS) and the linkages they have developed with many community-based agencies will allow us to reach effectively many of the children, adolescents and women known to be affected by the HIV epidemic in Chicago and the surrounding area. The addition of the two international CRSs will strengthen the ability of the CTU to pursue (and hopefully answer) scientific questions which are important to the international community where the majority of the pediatric and adolescent patients are located. US-based researchers with 20-plus years of HIV/AIDS expertise will share their experience and help the international sites to be more effective in their efforts to enroll and follow the large numbers of HIV-infected children, adolescents and women in South Africa and Thailand. ADMINISTRATIVE COMPONENT