Pediatric AIDS Clinical Trials Unit

描述（由申请人提供）：芝加哥儿科艾滋病临床 试验单位（C-PACTU）计划参加多中心艾滋病临床 协调和行动中心（CORC）提出的试验。我们的目标是 参与以假设为基础和以发病机制为导向的方案 试验旨在：1）确定病毒学和免疫学机制 围产期传播和评估抗逆转录病毒药物的潜力， 免疫调节剂（包括疫苗），以减少这种传播。（二） 迅速评估有希望的新的抗逆转录病毒组合的效果 病毒载量、免疫标志物和/或临床结果; 3）增加我们的 了解儿童和青少年的艾滋病毒免疫发病机制， 基于免疫和/或基因治疗的作用; 4）预防或管理机会性 感染，并研究其对艾滋病毒感染进展的影响; 5)促进艾滋病毒感染者的登记、治疗和依从性 青少年; 6）提高生活质量和长期结果。我们有 我们对第一/第二阶段研究特别感兴趣，并计划继续参与 在这些（更困难的）协议中。此外，我们计划增加 在我们单位接受护理的艾滋病毒感染妇女的参与， ACTG研究。C-PACTU的拟议四个单位位于不同的 芝加哥的部分地区。C-PACTG的广泛集水区， 它与许多社区机构建立的联系将使我们能够 有效地接触到许多儿童、青少年和妇女， 受艾滋病流行的影响，在芝加哥和周边地区。该单位是 同时也从事国际科学交流和研究， 在南非开普敦。

DESCRIPTION (provided by applicant): The Chicago Pediatric AIDS Clinical Trials Unit (C-PACTU) plans to participate in the multi-center AIDS clinical trials proposed by the Coordinating and Operations Center (CORC). Our goal is to participate in protocols that are hypothesis-based and pathogenesis-oriented trials designed to 1) define the virologic and immunologic mechanisms of perinatal transmission and evaluate the potential of antiretrovirals and immunomodulators (including vaccines) to reduce such transmission. 2) expeditiously evaluate the effect of promising new antiretroviral combinations on viral load, immunologic markers and/or clinical outcome; 3) increase our understanding of HIV immunopathogenesis in children and adolescents and the role of immune-based and/or gene therapy; 4) prevent or manage opportunistic infections and investigate their effect on the progression of HIV infection; 5) facilitate enrollment, treatment, and compliance of HIV-infected adolescents; and 6) increase quality of life and long-term outcomes. We have special interest in phase I/II studies and plan to continue our participation in these (more difficult) protocols. In addition, we plan to increase participation of HIV-infected women who are being cared for at our unit in ACTG studies. The proposed four units of the C-PACTU are located in different parts of the city of Chicago. The wide-range catchment area of the C-PACTG and the linkages it has developed with many community-based agencies will allow us to reach effectively many of the children, adolescents and women known to be affected by the HIV epidemic in Chicago and the surrounding area. The unit is also engaged in international scientific exchange and research with a site in Capetown, South Africa.