Units for HIV/AIDS Clinical Trials Networks

HIV/AIDS 临床试验网络单位

• 批准号: 8197694
• 负责人: Ram Yogev
• 金额: $ 152.36万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197694
• 关键词: AIDS prevention; AIDS/HIV problem; Adolescent; Affect; Area; Catchment Area; Chicago; Child; Childhood; Clinical Research; Clinical Treatment; Clinical Trials Design; Clinical Trials Network; Communities; Comorbidity; Enrollment; Epidemic; Goals; HIV; Immune system; Infection; International; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Pathogenesis; Patients; Pregnant Women; Prevention; Protocols documentation; Research Personnel; Site; South Africa; Thailand; United States; Vaccines; Vertical Disease Transmission; Woman; base; clinical research site; experience; improved

DESCRIPTION (provided by applicant): The Chicago Clinical Treatment Unit (CTU) plans to participate in the clinical research proposed by the International Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT) network. Our goal is to participate in protocols that are hypothesis-based and pathogenesis-oriented trials designed to 1) advance the ability to interrupt mother-to-child transmission of HIV; 2) improve prevention and treatment interventions for children and adolescents in the United State and internationally; 3) evaluate treatments and prevention of co-infections and co-morbidities in HIV-infected children, adolescents and pregnant women; 4) evaluate vaccines for the prevention of HIV, or to boost the immune system of HIV-infected children and adolescents. The proposed four units of the Chicago CTU are located in different parts of the world. In Chicago, the wide-range catchment area of the Chicago Clinical Research Sites (CRS) and the linkages they have developed with many community-based agencies will allow us to reach effectively many of the children, adolescents and women known to be affected by the HIV epidemic in Chicago and the surrounding area. The addition of the two international CRSs will strengthen the ability of the CTU to pursue (and hopefully answer) scientific questions which are important to the international community where the majority of the pediatric and adolescent patients are located. US-based researchers with 20-plus years of HIV/AIDS expertise will share their experience and help the international sites to be more effective in their efforts to enroll and follow the large numbers of HIV-infected children, adolescents and women in South Africa and Thailand. ADMINISTRATIVE COMPONENT

描述(由申请者提供)：芝加哥临床治疗中心(CTU)计划参与由国际母婴青少年艾滋病临床试验(IMPAACT)网络提出的临床研究。我们的目标是参与以假设为基础和以发病机制为导向的试验方案，这些试验旨在1)提高阻断艾滋病毒母婴传播的能力；2)改善美国和国际上对儿童和青少年的预防和治疗干预措施；3)评估艾滋病毒感染儿童、青少年和孕妇中混合感染和并存的治疗和预防；4)评估预防艾滋病毒的疫苗，或增强艾滋病毒感染儿童和青少年的免疫系统。拟议中的芝加哥CTU的四个单位位于世界不同地区。在芝加哥，芝加哥临床研究站点(CRS)的大范围收集区域以及它们与许多社区机构建立的联系将使我们能够有效地接触到芝加哥及周边地区已知受艾滋病毒影响的许多儿童、青少年和妇女。 两个国际CRSS的增加将加强CTU寻求(并有望回答)对大多数儿科和青少年患者所在的国际社会重要的科学问题的能力。拥有20多年艾滋病毒/艾滋病专业知识的美国研究人员将分享他们的经验，并帮助国际网站更有效地努力登记和跟踪南非和泰国大量感染艾滋病毒的儿童、青少年和妇女。 管理组件