An Open Source Digital Pathology System Supporting Multi-Touch Interaction

支持多点触控交互的开源数字病理系统

• 批准号: 8199429
• 负责人: Beverly Elizabeth Faulkner-Jones
• 金额: $ 14.94万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199429
• 关键词: Accreditation; Address; Anatomy; Architecture; Area; Atlases; Biopsy; Client; Clinical; Collaborations; Collection; Communities; Computer software; Computer-Assisted Diagnosis; Computers; Data; Data Set; Development; Devices; Diagnosis; Diagnostic; Disease; Education; Educational process of instructing; Environment; Excision; Formalin; Glass; Goals; Health Care Costs; Hematoxylin and Eosin Staining Method; Histologic; Hospitals; Image; Image Analysis; Imagery; Individual; Information Systems; Instruction; Internet; Length; Lesion; Linux; Longevity; Manufacturer Name; Measurement; Medical; Medical Records; Metadata; Microscope; Paraffin; Pathologist; Pathology; Patient Care; Performance; Phase; Plug-in; Process; Radiology Specialty; Reading; Recording of previous events; Research; Resolution; Scanning; Site; Slide; Solutions; Specimen; Speed; Staging; Staining method; Stains; Stream; Supercomputing; Support System; Surgical Pathology; System; Technology; Three-dimensional analysis; Tissues; Touch sensation; Training and Education; Ursidae Family; Waxes; Work; base; computerized tools; cost; cost effective; data integration; design; digital; digital imaging; experience; flexibility; image processing; improved; innovation; insight; interest; medical schools; medical specialties; open source; preference; prototype; segmentation Image analysis; tool

DESCRIPTION (provided by applicant): Medical records are being digitized in order to improve patient care, and the integrated digitization of all components of the medical record will also help reduce the number of errors and reduce health care costs. Images form part of the medical record. In some specialty areas such as radiology, the use of digital imaging is widespread. However, in other specialties digital images are less frequently used. One example is anatomic (surgical) pathology in which a microscope is used to view tissue mounted on a glass slide to obtain an image, a practice that has not changed much over decades. Pathologists have been slow to transition from glass slides to digital imaging for reasons which relate to image acquisition and interpretation. High-resolution digital images are necessary for accurate diagnosis, and acquisition of these images has been slow and expensive. Advances in computer technology have increased the speed of acquisition and reduced costs such that slide digitizing systems are now available from major microscope manufacturers. For digital imaging to become widely accepted in pathology there is still need for innovation to improve performance at all stages of the imaging process including acquisition, user interfaces, display, analysis, access and long-term storage. Here we propose development of a freely available open source system that can operate on multiple different computing platforms (Windows, Mac OSX, Linux) and process slide image data for integration of digital pathology into hospital-wide clinical information systems. The client/server software will manage collection of the image data and create large high resolution images that can be streamed over standard networks for display and remote viewing. Features of the software will include the ability to annotate images as well as support three-dimensional multi-channel datasets. This will enable pathologists to rapidly step through images of successive sections from a tissue block and facilitate three-dimensional analysis of the lesion biopsied. As pathologists require an efficient and fast workflow and may have limited computer expertise, our goal will be to have software that is as fast and easy to use as a microscope- the standard by which pathologists will judge the usefulness of the tool. We will develop and evaluate several client applications, one based on a standard desktop workstation interface paradigm, another deployed within a web browser, and finally a third in a multi-touch environment supporting direct interaction with images. In addition the software will have a plug-in interface (API) that enables development of image processing modules as well as new client interfaces. Ultimately the open source system will have advantages for training, education, remote/collaborative viewing, and research. PUBLIC HEALTH RELEVANCE: Pathology has a storied history in the medical profession and is vital to the diagnosis and treatment of disease. Digital pathology has the potential to advance the efficiency and accuracy of the field, providing new tools for interaction, analysis, collaboration and education.

描述(申请人提供)：病历正在数字化，以改善患者护理，病历所有组成部分的综合数字化也将有助于减少差错数量和降低医疗成本。图像是医疗记录的一部分。在一些专业领域，如放射学，数字成像的使用是广泛的。然而，在其他专业中，数字图像的使用频率较低。一个例子是解剖(外科)病理学，使用显微镜观察安装在玻璃片上的组织以获得图像，这种做法几十年来没有太大改变。由于与图像采集和解释相关的原因，病理学家从玻片过渡到数字成像的速度一直很慢。高分辨率的数字图像对于准确的诊断是必要的，而这些图像的获取一直是缓慢和昂贵的。计算机技术的进步提高了获取的速度，降低了成本，因此现在可以从主要的显微镜制造商那里获得载玻片数字化系统。为了使数字成像在病理学中得到广泛接受，仍然需要创新来提高成像过程的所有阶段的性能，包括采集、用户界面、显示、分析、访问和长期存储。在这里，我们建议开发一个免费可用的开源系统，该系统可以运行在多种不同的计算平台(Windows、Mac OSX、Linux)上，并处理载玻片图像数据，以便将数字病理学集成到医院范围的临床信息系统中。客户端/服务器软件将管理图像数据的收集，并创建大型高分辨率图像，这些图像可以通过标准网络传输以供显示和远程查看。该软件的功能将包括对图像进行注释以及支持三维多通道数据集。这将使病理学家能够快速浏览来自组织块的连续切片的图像，并便于对活检的病变进行三维分析。由于病理学家需要高效、快速的工作流程，而且计算机专业知识可能有限，我们的目标将是拥有像显微镜一样快速、易于使用的软件--这是病理学家判断该工具是否有用的标准。我们将开发和评估几个客户端应用程序，一个基于标准桌面工作站界面范例，另一个部署在Web浏览器中，最后第三个在支持与图像直接交互的多点触摸环境中。此外，该软件将有一个插件界面(API)，可以开发图像处理模块以及新的客户界面。最终，开源系统将在培训、教育、远程/协作查看和研究方面具有优势。 公共卫生相关性：病理学在医疗行业有着悠久的历史，对疾病的诊断和治疗至关重要。数字病理学有可能提高该领域的效率和准确性，为互动、分析、合作和教育提供新的工具。