An Open Source Digital Pathology System Supporting Multi-Touch Interaction

支持多点触控交互的开源数字病理系统

• 批准号: 8199429
• 负责人: Beverly Elizabeth Faulkner-Jones
• 金额: $ 14.94万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199429
• 关键词: Accreditation; Address; Anatomy; Architecture; Area; Atlases; Biopsy; Client; Clinical; Collaborations; Collection; Communities; Computer software; Computer-Assisted Diagnosis; Computers; Data; Data Set; Development; Devices; Diagnosis; Diagnostic; Disease; Education; Educational process of instructing; Environment; Excision; Formalin; Glass; Goals; Health Care Costs; Hematoxylin and Eosin Staining Method; Histologic; Hospitals; Image; Image Analysis; Imagery; Individual; Information Systems; Instruction; Internet; Length; Lesion; Linux; Longevity; Manufacturer Name; Measurement; Medical; Medical Records; Metadata; Microscope; Paraffin; Pathologist; Pathology; Patient Care; Performance; Phase; Plug-in; Process; Radiology Specialty; Reading; Recording of previous events; Research; Resolution; Scanning; Site; Slide; Solutions; Specimen; Speed; Staging; Staining method; Stains; Stream; Supercomputing; Support System; Surgical Pathology; System; Technology; Three-dimensional analysis; Tissues; Touch sensation; Training and Education; Ursidae Family; Waxes; Work; base; computerized tools; cost; cost effective; data integration; design; digital; digital imaging; experience; flexibility; image processing; improved; innovation; insight; interest; medical schools; medical specialties; open source; preference; prototype; segmentation Image analysis; tool

DESCRIPTION (provided by applicant): Medical records are being digitized in order to improve patient care, and the integrated digitization of all components of the medical record will also help reduce the number of errors and reduce health care costs. Images form part of the medical record. In some specialty areas such as radiology, the use of digital imaging is widespread. However, in other specialties digital images are less frequently used. One example is anatomic (surgical) pathology in which a microscope is used to view tissue mounted on a glass slide to obtain an image, a practice that has not changed much over decades. Pathologists have been slow to transition from glass slides to digital imaging for reasons which relate to image acquisition and interpretation. High-resolution digital images are necessary for accurate diagnosis, and acquisition of these images has been slow and expensive. Advances in computer technology have increased the speed of acquisition and reduced costs such that slide digitizing systems are now available from major microscope manufacturers. For digital imaging to become widely accepted in pathology there is still need for innovation to improve performance at all stages of the imaging process including acquisition, user interfaces, display, analysis, access and long-term storage. Here we propose development of a freely available open source system that can operate on multiple different computing platforms (Windows, Mac OSX, Linux) and process slide image data for integration of digital pathology into hospital-wide clinical information systems. The client/server software will manage collection of the image data and create large high resolution images that can be streamed over standard networks for display and remote viewing. Features of the software will include the ability to annotate images as well as support three-dimensional multi-channel datasets. This will enable pathologists to rapidly step through images of successive sections from a tissue block and facilitate three-dimensional analysis of the lesion biopsied. As pathologists require an efficient and fast workflow and may have limited computer expertise, our goal will be to have software that is as fast and easy to use as a microscope- the standard by which pathologists will judge the usefulness of the tool. We will develop and evaluate several client applications, one based on a standard desktop workstation interface paradigm, another deployed within a web browser, and finally a third in a multi-touch environment supporting direct interaction with images. In addition the software will have a plug-in interface (API) that enables development of image processing modules as well as new client interfaces. Ultimately the open source system will have advantages for training, education, remote/collaborative viewing, and research. PUBLIC HEALTH RELEVANCE: Pathology has a storied history in the medical profession and is vital to the diagnosis and treatment of disease. Digital pathology has the potential to advance the efficiency and accuracy of the field, providing new tools for interaction, analysis, collaboration and education.

描述（由申请人提供）：正在对病历进行数字化以改善患者护理，并且医疗记录的所有组件的综合数字化也将有助于减少错误的数量并降低医疗保健费用。图像构成病历的一部分。在某些专业领域，例如放射学，数字成像的使用广泛。但是，在其他专业中，数字图像的使用频率较低。一个例子是解剖（外科）病理学，其中使用显微镜查看安装在载玻片上以获得图像的组织，这种习惯在数十年中并没有改变。由于与图像采集和解释有关的原因，病理学家从载玻片到数字成像的过渡缓慢。高分辨率的数字图像对于准确的诊断是必需的，并且这些图像的获取速度缓慢且昂贵。计算机技术的进步提高了采集速度和降低成本，因此现在可以从主要显微镜制造商那里获得幻灯片数字化系统。为了使数字成像在病理学中被广泛接受，仍需要创新在成像过程的各个阶段提高性能，包括获取，用户界面，显示，分析，访问和长期存储。在这里，我们建议开发一个可以在多个不同的计算平台（Windows，Mac OSX，Linux）和过程幻灯片图像数据中运行的免费开源系统，以将数字病理学集成到医院范围内的临床信息系统中。客户端/服务器软件将管理图像数据的收集，并创建可以通过标准网络流式传输的大型高分辨率图像，以进行显示和远程查看。该软件的功能将包括注释图像的能力以及支持三维多渠道数据集。这将使病理学家能够快速逐步浏览组织块的连续切片图像，并促进对病变活检的三维分析。由于病理学家需要高效且快速的工作流程，并且可能具有有限的计算机专业知识，因此我们的目标是拥有与显微镜一样快速且易于使用的软件 - 病理学家判断该工具有用性的标准。 我们将根据标准桌面工作站接口范式，另一个部署在Web浏览器中，最后是多点触摸环境中的三分之一，支持与图像的直接交互。此外，该软件将具有插件接口（API），该插件接口可以开发图像处理模块以及新的客户端接口。最终，开源系统将在培训，教育，远程/协作观看和研究方面具有优势。 公共卫生相关性：病理学在医学界有悠久的历史，对疾病的诊断和治疗至关重要。 数字病理有可能提高该领域的效率和准确性，从而为互动，分析，协作和教育提供新的工具。