Microtechnology-Enhanced Surgical Device For Pediatric Lens Capsulotomy And Treat

用于小儿晶状体囊切开术和治疗的微技术增强手术装置

基本信息

  • 批准号:
    8121974
  • 负责人:
  • 金额:
    $ 29.52万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-04-01 至 2012-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): We propose a new interventional device that solves a significant therapeutic bottleneck in the treatment of lens cataract in children. As the leading cause of childhood blindness, lens cataract interferes with the optical performance of the eye and if untreated, results in lifelong deficits in visual perception. The first step in pediatric cataract surgery is technically the most challenging and involves the creation of a hole in the thin and highly elastic lens capsule to provide access for the subsequent removal of the diseased lens and if needed, the implantation of an artificial lens. Due to the unique biomechanical properties of the immature lens capsule, adult procedures for creating the capsulotomy opening, if applied to infants and young children, only have a 20% chance of success. Capsule tears hinder lens removal and affect the mechanical stability and performance of artificial lens implants. Currently, pediatric cataract surgeons must make do using devices with tissue chopping functions originally designed for non-cataract surgical uses, resulting in suboptimal pediatric lens capsulotomies. In order to simplify and automate pediatric lens capsulotomies and thus enhance the delivery of vision care to young patients, we propose a micro and nanotechnology-enhanced capsulotomy device to achieve consistent results across a range of surgical skills. The device is based on a proprietary method of tissue cutting in which a microfabricated cutting ring is housed within a collapsible elastomeric housing to produce precise capsulotomies on a microsecond time scale. Our device is inserted through the standard 2.75 mm corneal incision and re-expands to produce a desired capsulotomy of 5.5 mm in diameter. In preliminary work, we have obtained proof of principle for important device functions including capsule cutting and device compressibility. In the proposed studies, we will optimize device component designs, choice of materials, and conduct engineering stress tests. Device function will also be tested using both ex vivo eye models and in a small surgical series in rabbits whose lens capsule mimics the elastic capsule of the pediatric lens. The goal of this Phase I study is the production and functional validation of an automated lens capsulotomy device suitable for extensive device safety and performance trials in Phase II. PUBLIC HEALTH RELEVANCE: This work seeks to develop a microtechnology and nanotechnology-enhanced surgical instrument to aid in the treatment of childhood blindness due to lens cataract. Lens cataract is the leading cause of pediatric visual disabilities, and cataract removal restores sight and improves the quality of life for both patients and their families. The proposed device simplifies and automates a technically challenging surgical task in cataract surgery.
描述(由申请人提供):我们提出了一种新的介入器械,可解决儿童透镜性白内障治疗中的重大治疗瓶颈。作为儿童失明的主要原因,透镜白内障干扰眼睛的光学性能,如果不治疗,会导致终身的视觉缺陷。小儿白内障手术的第一步在技术上是最具挑战性的,并且涉及在薄且高弹性的透镜囊中创建孔,以提供用于随后移除患病的透镜的通路,并且如果需要,植入人工透镜。由于未成熟的透镜囊的独特生物力学性质,用于创建囊切开术开口的成人手术,如果应用于婴儿和幼儿,只有20%的成功机会。囊膜撕裂阻碍透镜的取出并影响人工透镜植入物的机械稳定性和性能。目前,儿科白内障外科医生必须使用最初设计用于非白内障手术用途的具有组织切碎功能的装置,导致次优的儿科透镜囊切开术。 为了简化和自动化儿科透镜囊切开术,从而提高视力保健的年轻患者的交付,我们提出了一个微米和纳米技术增强的囊切开术设备,以实现一致的结果在一系列的手术技能。该器械基于组织切割的专有方法,其中微加工切割环容纳在可折叠弹性体外壳内,以在微秒时间尺度上进行精确的囊切开术。我们的装置通过标准的2.75 mm角膜切口插入,并重新扩张以产生直径为5.5 mm的所需囊切开术。在初步工作中,我们已经获得了重要器械功能(包括胶囊切割和器械压缩性)的原理证明。在拟议的研究中,我们将优化器件组件设计,材料选择,并进行工程应力测试。还将使用离体眼模型和家兔的小型手术系列(其透镜囊模仿小儿透镜的弹性囊)测试器械功能。本I期研究的目标是生产和功能确认适用于II期广泛器械安全性和性能试验的自动透镜囊切开器械。 公共卫生关系:这项工作旨在开发一种微技术和纳米技术增强的手术器械,以帮助治疗儿童因透镜白内障而失明。透镜白内障是儿童视力残疾的主要原因,白内障摘除术可以恢复视力,提高患者及其家人的生活质量。申报器械简化了白内障手术中具有技术挑战性的手术任务并实现了自动化。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(4)

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Christopher Keller其他文献

Christopher Keller的其他文献

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{{ truncateString('Christopher Keller', 18)}}的其他基金

Micro-technology Enhanced Pediatric Lens Capsulotomy Device
微技术增强型小儿晶状体囊切开术装置
  • 批准号:
    8514224
  • 财政年份:
    2011
  • 资助金额:
    $ 29.52万
  • 项目类别:
Micro-technology Enhanced Pediatric Lens Capsulotomy Device
微技术增强型小儿晶状体囊切开术装置
  • 批准号:
    8913399
  • 财政年份:
    2011
  • 资助金额:
    $ 29.52万
  • 项目类别:
Micro-technology Enhanced Pediatric Lens Capsulotomy Device
微技术增强型小儿晶状体囊切开术装置
  • 批准号:
    8652460
  • 财政年份:
    2011
  • 资助金额:
    $ 29.52万
  • 项目类别:
Micro/Nano Devices For Neuroscience Research
用于神经科学研究的微/纳米器件
  • 批准号:
    7798300
  • 财政年份:
    2010
  • 资助金额:
    $ 29.52万
  • 项目类别:

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