BIOLOGICAL TREATMENT STRATEGIES FOR GROWTH FACTORS AND CYTOKINES INHIBITORS
生长因子和细胞因子抑制剂的生物治疗策略
基本信息
- 批准号:8131120
- 负责人:
- 金额:$ 29.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:2 year oldAddressAdolescentAdultAgeAnimal ModelBackBack PainBiochemicalBiologicalBiomechanicsCell SurvivalCellsChondroitin ABC LyaseChronicClinicalEquilibriumEtiologyExhibitsFundingGrowth FactorHealth Care CostsHumanHuman PathologyIn VitroInflammationInflammatoryInjection of therapeutic agentInterleukin-1Intervertebral Disk ChemolysisIntervertebral disc structureLow Back PainMeasuresMediatingMetabolicMetabolismModelingNatural regenerationNeedlesNerveNerve Growth FactorsNutrientNutritionalNutritional statusOryctolagus cuniculusPainPathway interactionsPhase I Clinical TrialsProteinsPuncture procedureResearchResearch PersonnelSamplingSourceStagingStructureSurrogate MarkersSystemTestingTherapeuticTranslatingTumor Necrosis Factor-alphaTumor Necrosis Factorsanakinrabone morphogenetic protein 7clinically relevantcytokinedisc regenerationgrowth differentiation factor 5in vivoinhibitor/antagonistintervertebral disk degenerationmature animalnucleus pulposusnutritionprogramsreceptorrepairedsocioeconomicssolutetreatment strategy
项目摘要
We have shown that the rabbit disc degeneration model, which is induced by puncturing the annulus
fibrosus with needles of defined gauges, resulted in reproducible, degenerative changes that could be
quantitatively assessed. Our initial hypothesis that an injection of the growth factor, osteogenic protein-1, is
able to regenerate the intervertebral disc was shown to be true using this model. This promising protein
injection therapy approach will soon be translated into a Phase I clinical trial as the first injection therapy
using a growth factor. The approaches in the proposed funding period are to: (1) test if the injection of a
growth factor into a disc also stimulates repair in a more clinically relevant model using adult rabbits; (2)
expand therapeutic approaches to the application of cytokine inhibitory molecules; and (3) delineate the
limitations of such therapy under conditions where nutrition levels in the disc are compromised. In addition,
efforts will be extended to identify changes in nerve-related cytokines, i.e. nerve growth factor, in the rabbit
model and in cadaveric samples, as potential surrogate markers of low back pain. Hypothesis 1: Disc
degeneration can be delayed or reversed by manipulating the balance between anabolic and catabolic
pathways; some manipulations will result in decreased pain associated with disc degeneration. In Specific
Aim 1, we will test if growth factors (osteogenic protein-1, growth differentiation factor-5) and/or inhibitory
molecules of cytokines (interleukin-1 receptor antagonist, tumor necrosis factor-a soluble receptor) delay the
progression of disc degeneration or restore the degenerated disc using an in vivo protein injection in a
mature rabbit chronic disc degeneration model. Hypothesis 2: Compromised nutrient transport through the
endplate limits cell-mediated disc repair induced by the application of a growth factor. In Specific Aim 2 we
will investigate changes in nutrient transport in the rabbit annular puncture model of disc degeneration and
identify the presence of a critical level of nutrient transport that is deleterious to matrix metabolism. Low back
pain is responsible for enormous human suffering, high health care costs and significant socioeconomic
losses. Although the etiology of back pain is often unknown, the intervertebral disc is a significant source of
back problems. The results from this study will advance the field of biological treatment for intervertebral
disc degeneration.
我们已经证明了兔椎间盘退变模型,这是由穿刺环引起的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Howard S An其他文献
Howard S An的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Howard S An', 18)}}的其他基金
RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS
椎间盘和小关节退变与体内腰椎运动学之间的关系
- 批准号:
7915744 - 财政年份:2009
- 资助金额:
$ 29.41万 - 项目类别:
BIOLOGICAL TREATMENT STRATEGIES FOR GROWTH FACTORS AND CYTOKINES INHIBITORS
生长因子和细胞因子抑制剂的生物治疗策略
- 批准号:
7915747 - 财政年份:2009
- 资助金额:
$ 29.41万 - 项目类别:
RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS
椎间盘和小关节退变与体内腰椎运动学之间的关系
- 批准号:
7486862 - 财政年份:2007
- 资助金额:
$ 29.41万 - 项目类别:
BIOLOGICAL TREATMENT STRATEGIES FOR GROWTH FACTORS AND CYTOKINES INHIBITORS
生长因子和细胞因子抑制剂的生物治疗策略
- 批准号:
7486865 - 财政年份:2007
- 资助金额:
$ 29.41万 - 项目类别:
RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS
椎间盘和小关节退变与体内腰椎运动学之间的关系
- 批准号:
7223261 - 财政年份:2006
- 资助金额:
$ 29.41万 - 项目类别:
BIOLOGICAL TREATMENT STRATEGIES FOR GROWTH FACTORS AND CYTOKINES INHIBITORS
生长因子和细胞因子抑制剂的生物治疗策略
- 批准号:
7223266 - 财政年份:2006
- 资助金额:
$ 29.41万 - 项目类别:
RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS
椎间盘和小关节退变与体内腰椎运动学之间的关系
- 批准号:
8131117 - 财政年份:
- 资助金额:
$ 29.41万 - 项目类别:
相似海外基金
Enhancing Structural Competency in School-Based Health Centers to Address LGBTQ+ Adolescent Health Equity
增强校本健康中心的结构能力,以解决 LGBTQ 青少年健康公平问题
- 批准号:
10608426 - 财政年份:2023
- 资助金额:
$ 29.41万 - 项目类别:
Application and feasability of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care - a pilot study
简短的数字筛查工具的应用和可行性,以解决儿科医疗中父母和青少年烟草和电子烟的使用问题 - 一项试点研究
- 批准号:
486580 - 财政年份:2022
- 资助金额:
$ 29.41万 - 项目类别:
Studentship Programs
Co-design of an intervention to address alcohol use among adolescent boys and young men in Tanzania
共同设计一项干预措施,解决坦桑尼亚青春期男孩和年轻男性的饮酒问题
- 批准号:
MR/V032380/1 - 财政年份:2022
- 资助金额:
$ 29.41万 - 项目类别:
Research Grant
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
- 批准号:
MR/V005790/1 - 财政年份:2021
- 资助金额:
$ 29.41万 - 项目类别:
Research Grant
Application of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care
应用简短的数字筛查工具来解决儿科医疗中父母和青少年烟草和电子烟的使用问题
- 批准号:
455984 - 财政年份:2021
- 资助金额:
$ 29.41万 - 项目类别:
Operating Grants
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
- 批准号:
MR/V005790/2 - 财政年份:2021
- 资助金额:
$ 29.41万 - 项目类别:
Research Grant
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
- 批准号:
10057761 - 财政年份:2020
- 资助金额:
$ 29.41万 - 项目类别:
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
- 批准号:
10213683 - 财政年份:2020
- 资助金额:
$ 29.41万 - 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
- 批准号:
9403567 - 财政年份:2017
- 资助金额:
$ 29.41万 - 项目类别:
Designing targeted interventions to address HIV vulnerabilities and improve clinical outcomes among conflict affected adolescent girls and young women under 25 in Northern Uganda
设计有针对性的干预措施,以解决乌干达北部受冲突影响的少女和 25 岁以下年轻妇女的艾滋病毒脆弱性并改善临床结果
- 批准号:
356145 - 财政年份:2016
- 资助金额:
$ 29.41万 - 项目类别:
Operating Grants