RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS
椎间盘和小关节退变与体内腰椎运动学之间的关系
基本信息
- 批准号:7486862
- 负责人:
- 金额:$ 15.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-01 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:AgeBiologicalBiological PreservationBiomechanicsCervicalChronic low back painClinicalConditionDataDevelopmentDiagnosisDiseaseElementsEvaluationFacet joint structureGoalsGrantHeightIn VitroIntervertebral disc structureInvasiveLateralLow Back PainMagnetic Resonance ImagingMeasurementMeasuresMechanical Low Back PainMethodsModelingMotionMovementOutcomePainPatternPositioning AttributePrognostic FactorProgram Research Project GrantsRangeRecruitment ActivityResearchSeveritiesSimulateSpinalSpinal Degenerative DisorderSymptomsTechniquesTestingTimeTorsionValidationVertebral columnVisual Analogue Pain ScaleWeightX-Ray Computed Tomographyanalytical methodbasedesignin vivointervertebral disk degenerationkinematicspressuresexsizetransmission processvirtual
项目摘要
The proposed study focuses on understanding and developing new methods to diagnose low back pain
problems resulting from both segmental instability and degenerative changes in intervertebral discs and/or
facets. In the ongoing study, we found that a relationship exists between the severity of intervertebral disc
degeneration and increases in torsional and flexion-extension movements. Significant differences were
found in facet degeneration and disc degeneration between the asymptomatic and the symptomatic
subjects. However, the mechanistic relationship between disc degeneration and the facet joint remains to
be clarified. In Project 1 of the renewal Program Project Grant, we will define kinematic hypermobility in
torsion and flexion-extension in vivo and correlate those measurements with low back pain symptoms. We
will identify factors of prognostic importance to the progression of disc and facet joint degeneration and
symptoms. We propose a five-year study of the in vivo relationship of degenerative changes with segmental
instability of the lumbar spine. In this proposed study, we will re-evaluate, over a five-year interval, 25
asymptomatic normal subjects and 25 age- and sex-matched symptomatic subjects, who were investigated
in the current grant cycle. Hypotheses that we will test in this study are (1) that greater segmental mobility
and/or specific kinematic patterns contribute to accelerated intervertebral disc and facet degeneration over
time, and (2) that load transmission through the facet joints depends on the loading direction and
intervertebral disc degeneration and height, and motion segment level and facet orientation. The specific
aims are (1) to measure changes in rotational and flexion/extension segmental movement associated with
disc and facet degeneration over five years within each subject (a longitudinal in vivo study comparing
normal subjects and mechanical low back pain subjects), and (2) to investigate, using cadaveric lumbar
spines, relationships among disc degeneration and height, segmental movement, disc pressure and facet
joint pressure, and to analyze correlations between altered kinematics and load transmission (an
experimental in vitro study). The outcome from the proposed study is expected to be equally effective for
diagnosis of cervical spinal instability and evaluating many of new motion preservation treatment alternatives
in use or under development.
本研究的重点是了解和发展诊断腰痛的新方法
项目成果
期刊论文数量(0)
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{{ truncateString('Howard S An', 18)}}的其他基金
RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS
椎间盘和小关节退变与体内腰椎运动学之间的关系
- 批准号:
7915744 - 财政年份:2009
- 资助金额:
$ 15.57万 - 项目类别:
BIOLOGICAL TREATMENT STRATEGIES FOR GROWTH FACTORS AND CYTOKINES INHIBITORS
生长因子和细胞因子抑制剂的生物治疗策略
- 批准号:
7915747 - 财政年份:2009
- 资助金额:
$ 15.57万 - 项目类别:
BIOLOGICAL TREATMENT STRATEGIES FOR GROWTH FACTORS AND CYTOKINES INHIBITORS
生长因子和细胞因子抑制剂的生物治疗策略
- 批准号:
7486865 - 财政年份:2007
- 资助金额:
$ 15.57万 - 项目类别:
RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS
椎间盘和小关节退变与体内腰椎运动学之间的关系
- 批准号:
7223261 - 财政年份:2006
- 资助金额:
$ 15.57万 - 项目类别:
BIOLOGICAL TREATMENT STRATEGIES FOR GROWTH FACTORS AND CYTOKINES INHIBITORS
生长因子和细胞因子抑制剂的生物治疗策略
- 批准号:
7223266 - 财政年份:2006
- 资助金额:
$ 15.57万 - 项目类别:
RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS
椎间盘和小关节退变与体内腰椎运动学之间的关系
- 批准号:
8131117 - 财政年份:
- 资助金额:
$ 15.57万 - 项目类别:
BIOLOGICAL TREATMENT STRATEGIES FOR GROWTH FACTORS AND CYTOKINES INHIBITORS
生长因子和细胞因子抑制剂的生物治疗策略
- 批准号:
8131120 - 财政年份:
- 资助金额:
$ 15.57万 - 项目类别:
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