RELATIONSHIP BETWEEN DISC AND FACET DEGENERATION AND IN VIVO LUMBAR KINEMATICS

椎间盘和小关节退变与体内腰椎运动学之间的关系

• 批准号: 7486862
• 负责人: Howard S An
• 金额: $ 15.57万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7486862
• 关键词: Age; Biological; Biological Preservation; Biomechanics; Cervical; Chronic low back pain; Clinical; Condition; Data; Development; Diagnosis; Disease; Elements; Evaluation; Facet joint structure; Goals; Grant; Height; In Vitro; Intervertebral disc structure; Invasive; Lateral; Low Back Pain; Magnetic Resonance Imaging; Measurement; Measures; Mechanical Low Back Pain; Methods; Modeling; Motion; Movement; Outcome; Pain; Pattern; Positioning Attribute; Prognostic Factor; Program Research Project Grants; Range; Recruitment Activity; Research; Severities; Simulate; Spinal; Spinal Degenerative Disorder; Symptoms; Techniques; Testing; Time; Torsion; Validation; Vertebral column; Visual Analogue Pain Scale; Weight; X-Ray Computed Tomography; analytical method; base; design; in vivo; intervertebral disk degeneration; kinematics; pressure; sex; size; transmission process; virtual

The proposed study focuses on understanding and developing new methods to diagnose low back pain problems resulting from both segmental instability and degenerative changes in intervertebral discs and/or facets. In the ongoing study, we found that a relationship exists between the severity of intervertebral disc degeneration and increases in torsional and flexion-extension movements. Significant differences were found in facet degeneration and disc degeneration between the asymptomatic and the symptomatic subjects. However, the mechanistic relationship between disc degeneration and the facet joint remains to be clarified. In Project 1 of the renewal Program Project Grant, we will define kinematic hypermobility in torsion and flexion-extension in vivo and correlate those measurements with low back pain symptoms. We will identify factors of prognostic importance to the progression of disc and facet joint degeneration and symptoms. We propose a five-year study of the in vivo relationship of degenerative changes with segmental instability of the lumbar spine. In this proposed study, we will re-evaluate, over a five-year interval, 25 asymptomatic normal subjects and 25 age- and sex-matched symptomatic subjects, who were investigated in the current grant cycle. Hypotheses that we will test in this study are (1) that greater segmental mobility and/or specific kinematic patterns contribute to accelerated intervertebral disc and facet degeneration over time, and (2) that load transmission through the facet joints depends on the loading direction and intervertebral disc degeneration and height, and motion segment level and facet orientation. The specific aims are (1) to measure changes in rotational and flexion/extension segmental movement associated with disc and facet degeneration over five years within each subject (a longitudinal in vivo study comparing normal subjects and mechanical low back pain subjects), and (2) to investigate, using cadaveric lumbar spines, relationships among disc degeneration and height, segmental movement, disc pressure and facet joint pressure, and to analyze correlations between altered kinematics and load transmission (an experimental in vitro study). The outcome from the proposed study is expected to be equally effective for diagnosis of cervical spinal instability and evaluating many of new motion preservation treatment alternatives in use or under development.

本研究的重点是了解和发展诊断腰痛的新方法