A Virtual Reality Simulator to Study VLSBA and Test Brain-Actuating Technologies

用于研究 VLSBA 和测试大脑驱动技术的虚拟现实模拟器

• 批准号: 8153106
• 负责人: Miguel A. L. Nicolelis
• 金额: $ 77.72万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8153106
• 关键词: Behavior; Behavioral; Brain; Brain imaging; Clinical; Cognitive; Complex; Computers; Data; Devices; Elements; Engineering; Environment; Environment Design; Future; Genetic; Goals; Imaging Device; Investigation; Laboratories; Limb structure; Magnetic Resonance Imaging; Measures; Methods; Motor; Movement; Neurons; Neurosciences; Paralysed; Patients; Property; Prosthesis; Research; Robotics; Sensory; Series; Technology; Testing; Touch sensation; abstracting; brain machine interface; design; human subject; innovation; mind control; nervous system disorder; neural circuit; neurophysiology; nonhuman primate; supercomputer; tool; virtual; virtual reality

Abstract: For the past 25 years, my research has focused on the investigation of the basic neurophysiological principles that allow neural circuits in the mammalian brain to generate sensory, motor, and cognitive behaviors. To pursue this goal, my laboratory has developed a series of highly innovative experimental approaches that combine electrophysiological, genetic, pharmacological, behavioral, computational, and engineering tools. Utilizing those, our laboratory has pioneered a revolutionary paradigm known as brain-machine interfaces (BMIs). Using BMIs, we have demonstrated that non-human primates and human subjects can effectively use their brain-derived electrical activity to directly control the movements of complex artificial devices, such as computer tools and prosthetic limbs. Yet, BMI research has barely touched the enormous biomedical potential that brain-actuating technologies will likely have in the future of both basic and clinical neuroscience. To start probing this future, I propose to develop the first shared brain-controlled virtual reality environment (BC-VRE) designed to investigate the dynamic properties of very-large scale brain activity (VLSBA) and the full potential of brain-actuating technologies for treating neurological disorders. The core of this virtual reality simulator will be formed by interfacing modern electrophysiological, magnetoenecephalographic (MEG), and brain imaging devices to a supercomputer cluster capable of rendering a virtual reality environment in which all constituent elements, including a variety of computational and robotic tools, and even virtual bodies, can be directly controlled by the VLSBA of interacting subjects. Initially, VLSBA will be obtained using a new method for mega-channel (up to 100,000 single neurons) recordings in non-human primates. Later on, the BC-VRE will also accept local or remote MEG/MRI data from human subjects. The BC-VRE will be initially used to: (1) measure how artificial tools are assimilated by the brain¿s representation of the subject¿s body, and (2) test the design of a whole-body neuroprosthetic device for severely paralyzed patients.

文摘:

项目成果

A Brain to Spine Interface for Transferring Artificial Sensory Information.

用于传输人工感觉信息的大脑到脊柱接口。

• DOI: 10.1038/s41598-020-57617-3
• 发表时间: 2020
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Yadav,AmolP;Li,Daniel;Nicolelis,MiguelAL
• 通讯作者: Nicolelis,MiguelAL

Stochastic facilitation of artificial tactile sensation in primates.

• DOI: 10.1523/jneurosci.3115-12.2012
• 发表时间: 2012-10-10
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Medina LE;Lebedev MA;O'Doherty JE;Nicolelis MA
• 通讯作者: Nicolelis MA

Adaptive decoding for brain-machine interfaces through Bayesian parameter updates.

• DOI: 10.1162/neco_a_00207
• 发表时间: 2011-12
• 期刊: Neural computation
• 影响因子: 2.9
• 作者: Li Z;O'Doherty JE;Lebedev MA;Nicolelis MA
• 通讯作者: Nicolelis MA

Active tactile exploration using a brain-machine-brain interface.

• DOI: 10.1038/nature10489
• 发表时间: 2011-10-05
• 期刊: NATURE
• 影响因子: 64.8
• 作者: O'Doherty, Joseph E.;Lebedev, Mikhail A.;Ifft, Peter J.;Zhuang, Katie Z.;Shokur, Solaiman;Bleuler, Hannes;Nicolelis, Miguel A. L.
• 通讯作者: Nicolelis, Miguel A. L.

Reprogramming movements: extraction of motor intentions from cortical ensemble activity when movement goals change.

重新编程运动：当运动目标改变时，从皮质整体活动中提取运动意图。

• DOI: 10.3389/fneng.2012.00016
• 发表时间: 2012
• 期刊: Frontiers in neuroengineering
• 作者: Ifft,PeterJ;Lebedev,MikhailA;Nicolelis,MiguelAL
• 通讯作者: Nicolelis,MiguelAL