TOXICOLOGY PROJECT

项目2：毒理学项目主任/首席调查员(最后、第一、中间)：Natalicio，Diana S./Kirken，Robert 1.重新提交申请简介 这是在第一个审查周期中被评为“良好”的应用程序的修订版。我们感谢审查员的有益评论和建议，并在整个提案过程中解决了大多数关切问题。主要的批评之一是缺乏扩大翻译研究的详细计划 由项目提供。具有翻译潜力的新倡议的一个具体例子在第5.2.2节中概述，以及药理学或分子毒理学的直接聘用。第二个主要批评是缺乏现场分析药品和个人护理产品衍生品水样所需的设备。请参阅核心B中描述的GC MS功能的说明，对于大多数应用程序来说应该绰绰有余，对于其余的应用程序，已包括一个预算项目，用于发送样本进行额外分析。其他批评在下面的叙述中进行了阐述。 毒理学项目(TOXP)是BBRC内三个广泛的研究小组之一，另外还有传染病和免疫学项目(IDIP)以及神经学和代谢紊乱(见下图1)。TOXP促进和促进项目内、项目之间、与UTEP其他部门以及UTEP以外的调查人员之间的合作。如下面详细概述的， TOXP积极支持环境、人类和动物健康问题的基础研究，因为这些问题涉及毒理学学科。美墨边境的关键或关键问题是：重金属污染和暴露、来自国内和国际来源的水污染、空气污染以及与之相关的急性和长期暴露于环境污染物的情况，这些污染物源于 一套污染空气的小分子。TOXP的研究专业知识和高度专业化的设备使我们能够在这些领域从事最先进的研究。TOXP通过支持参加地方、区域、国家和国际会议的旅行，促进和支持研究成果的传播。除了支持参加专业会议外，TOXP还为参加其他专业发展机会提供资金，例如参加专门的研讨会。 TOXP的研究议程与IDIP和NMDP很好地结合在一起。我们的研究小组之间的合作努力在下面的第4.2节中进行了描述。这一总体任务加强了我们目前的毒理学研究努力，并增加了我们研究人员未来在获得外部资金方面的竞争力 学生和社区教育，以及以假设和需求为导向的对美墨边境环境污染问题的研究。

PROJECT 2:TOXICOLOGY Program Director/Principal Investigator (Last, First, Middle): Natalicio, Diana S./Kirken, Robert 1. Introduction to Resubmission Application This is the revised version of an application that was rated "Good" in the first review cycle. We appreciate the reviewer's helpful comments and suggestions and have addressed the majority of the concerns throughout this proposal. One of the major criticisms was the lack of a detailed plan for the expansion of translational research by the Project. One specific example of a new initiative with translational potential is outlined in Section 5.2.2 as well as a directed hire in pharmacology or molecular toxicology. The second major criticism was the lack of needed equipment on-site for analyzing water samples for Pharmaceuticals and personal care product derivatives. Please see the description of the GC MS capabilities described under Core B which should be more than sufficient for most applications, for the remainder a budget item has been included to send the samples out for additional analyses. Other criticisms are addressed in the following narrative. The Toxicology Project (TOXP) is one of the three broad research groups within the BBRC, along with the Infectious Disease and Immunology Project (IDIP) and Neurology and Metabolic Disorders (see Figure 1 below). TOXP promotes and fosters collaboration among Pis within the Project, among Projects, with other Departments at UTEP as well as with investigators located outside of UTEP. As outlined in detail below, TOXP actively supports the basic research into environmental, human and animal health issues as they relate to the discipline of Toxicology. Key or crucial issues along the U.S.-Mexico border are: heavy metal contamination and exposure, water pollution from both domestic and international sources, air pollution and the associated acute and chronic exposure to the environmental contaminants originating from the deposition of a suite of small molecules that pollute the air. TOXP research expertise and access to highly specialized equipment allows us to engage in state of the art research in these areas. TOXP promotes and supports dissemination of research findings by supporting travel to local, regional, national and international conferences. Aside from supporting participation at professional meetings, TOXP provides funds for participation in other professional development opportunities such as attendance to specialized workshops. TOXP's research agenda is well integrated with IDIP and NMDP. Collaborative efforts among our research groups are described below in Section 4.2. This overall mission enhances our current Toxicology research efforts and increases the future competitiveness of our investigators toward securing extramural funding for student and community education in addition to hypothesis- and need-driven research into environmental pollution issues along the U.S.-Mexico border.