TOXICOLOGY PROJECT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 毒理学项目的目标是更好地了解毒性和解毒的机制，并扩大与毒理学有关的边界活动的范围。具体目标是：1)对格兰德河埃尔帕索-华雷斯河段、地下水和其他区域水源的污染物水平及其生物影响进行详细研究；2)增加药理学和毒理学研究，这将直接转化为解决埃尔帕索/华雷斯边境地区边境健康问题的办法；3)招聘两名新的毒理学教员，他们具有这些领域的研究专门知识，将直接补充新的研究举措。环境毒理学倡议将旨在详细研究格兰德河埃尔帕索-华雷斯段的水质和污染物水平、地下水和其他区域水源，重点是环境中的药品和个人护理产品(PPCP)。这一领域的新研究举措将旨在开发和实施新的筛选方法，最终目标是建立对这些化合物的实时监测系统。这些分子毒理学和药理学倡议将是一项跨学科的合作努力，旨在提供靶标表征、用于识别小分子疗法的高通量筛选分析以及这些分子的毒性测试方面的专业知识和研究能力。这些拟议的新举措将增加毒理学项目内正在进行的研究的翻译相关性，同时解决边境地区当前和新出现的关切问题。为了取得成功，这些新举措和相关的试点项目将需要得到BBRC核心设施的大力支持，并需要通过拟议的试点项目机制获得BBRC的资金。将通过招聘两名新的毒物学家、为水生湿实验室提供技术支持人员以及与德克萨斯理工学院医学院和其他区域实体合作来加强成功。这些努力将开发国际公认的毒理学研究计划，最终将通过NIH RO1补助金、多次PI NIH补助金、学生培训补助金和其他计划补助金获得资金。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Toxicology Project goals are to gain a better understanding of mechanisms of toxicity and detoxification and to expand the scope of toxicology related activities on the border. Specific aims are: 1) To implement detailed studies into contaminant levels and their biological impact in the El Paso-Ciudad Juarez stretch of the Rio Grande river, groundwater and other regional water sources, 2) To increase pharmacology and toxicology research which will directly translate into solutions for solving border health issues in the El Paso/Ciudad Juarez border region, and 3) To recruit two new toxicology faculty members with research expertise in these areas that will directly complement the new research initiatives. The environmental toxicology initiative will be aimed at detailed studies of water quality and contaminant levels in the El Paso-Ciudad Juarez stretch of the Rio Grande, groundwater, and other regional water sources with a specific focus on Pharmaceuticals and Personal Care Products (PPCPs) in the environment. New research initiatives in this area will be aimed at developing and implementing new screening methods with the ultimate goal of establishing a real-time monitoring system for these compounds. These molecular toxicology and pharmacology initiative will an interdisciplinary collaborative effort aimed at providing expertise and research capacity in target characterization, high-throughput screening assays for the identification of small molecule therapeutics, and toxicity testing of these molecules. These proposed, new initiatives will increase the translational relevance of research being conducted within the Toxicology Project while addressing current and emerging issues of concern within the border region. In order to be successful these new initiatives and associated pilot projects will require significant support from the BBRC core facilities and BBRC funding through the proposed pilot project mechanism. Success will be enhanced through the recruitment of the two new toxicologists, providing technical support personnel for the Aquatic Wet Laboratory, and collaborating with the Texas Tech Medical School and other regional entities. These efforts will develop and internationally recognized Toxicology research program that will ultimately obtain funding through NIH RO1 grants, multiple PI NIH grants, student training grants and other programmatic grants.