Exercise training and insulin resistance in overweight children and adolescents
超重儿童和青少年的运动训练和胰岛素抵抗
基本信息
- 批准号:8201812
- 负责人:
- 金额:$ 4.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-12-15 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:ATP Synthesis PathwayAdherenceAdolescentAffectAlanineAmino AcidsBiologicalBiological MarkersBiological ProcessBlood PressureBody WeightCardiovascular systemChildChildhoodCitric Acid CycleClinical TrialsComplexCreatinineDevelopmentEatingEducational InterventionEndocrinologyEpidemicExerciseFutureGenerationsGlutamatesGlycerolHDL-triglycerideHealth BenefitHome environmentHomeostasisInsulinInsulin ResistanceLeadLife ExpectancyLightLinkLipidsLower ExtremityMagnetic Resonance SpectroscopyMeasuresMediatingMetabolicMitochondriaModelingModificationMolecular WeightMonitorObesityOvernutritionOverweightOxidative PhosphorylationOxygenParentsPathogenesisPathway interactionsPatientsPhenotypePhosphocreatinePhysiciansPhysiologicalPhysiologyPopulationPublic HealthRandomized Controlled TrialsRecoveryRegimenResearch PersonnelRiskSkeletal MuscleTechnologyTestingTrainingUnited StatesVulnerable PopulationsWorkfitnessimprovedindexinginsightinsulin sensitivitylipid metabolismmuscle formnovelnutritionskillssugaruptakewaist circumference
项目摘要
DESCRIPTION (provided by applicant): Children and adolescents in the United States continue to eat more and exercise less than their parents did a generation ago; this combination of overnutrition and inactivity is partly to blame for an epidemic of obesity that threatens to shorten life expectancy of young people. Many of the adverse sequelae of obesity are mediated by insulin resistance. Understanding how to reverse obesity-associated insulin resistance in this vulnerable population is of critical public health importance. The proposed study is a randomized controlled trial to evaluate the impact of a supervised in-home 8-week exercise training intervention on insulin resistance in overweight children and adolescents, and to explore the mechanisms by which fitness-related amelioration of insulin resistance may occur. Specifically, we hypothesize that exercise will produce alterations in skeletal muscle physiology that will improve insulin sensitivity. The amount of lean mass, mitochondrial function, and intramyocellular lipid content are candidate modulators of insulin resistance at the level of the skeletal muscle that may be affected by exercise; we will investigate the potential contribution of each of these to exercise- related changes in insulin sensitivity. Finally, to support and extend our findings, we propose to simultaneously measure the concentrations of many metabolites (amino acids, sugars, low molecular weight lipids). We hope to identify other biological pathways modifiable by exercise and associated with better insulin sensitivity that can be the focus of future work. A better understanding of how exercise may ameliorate insulin resistance could shed light on pathogenesis of this condition and lead to more effective exercise prescriptions for patients.
PUBLIC HEALTH RELEVANCE: Children and adolescents in the United States continue to eat more and exercise less than their parents did a generation ago; this combination of excess nutrition and inactivity is partly to blame for an epidemic of obesity that threatens to shorten life expectancy of young people. We propose a study to evaluate whether exercise can reverse some of the harmful effects of obesity in this important population, and if so, how it might work. We hope that a better understanding of how exercise helps will lead to insights into obesity and its consequences in children and adolescents, as well as more effective exercise prescriptions for our pediatric patients.
描述(由申请人提供):美国的儿童和青少年继续比他们的父母一代人吃得更多,锻炼得更少;这种营养过剩和缺乏运动的结合是肥胖流行的部分原因,肥胖可能会缩短年轻人的预期寿命。肥胖的许多不良后遗症是由胰岛素抵抗介导的。了解如何扭转肥胖相关的胰岛素抵抗在这个脆弱的人群是至关重要的公共卫生重要性。这项研究是一项随机对照试验,旨在评估为期8周的监督性家庭运动训练干预对超重儿童和青少年胰岛素抵抗的影响,并探讨与健身相关的胰岛素抵抗改善可能发生的机制。具体来说,我们假设运动会改变骨骼肌的生理机能,从而改善胰岛素敏感性。瘦体重、线粒体功能和肌细胞内脂质含量是可能受运动影响的骨骼肌水平的胰岛素抵抗的候选调节剂;我们将研究这些因素中的每一个对运动相关的胰岛素敏感性变化的潜在贡献。最后,为了支持和扩展我们的发现,我们建议同时测量许多代谢物(氨基酸,糖,低分子量脂质)的浓度。我们希望确定其他可通过运动改变的生物途径,并与更好的胰岛素敏感性相关,这可能是未来工作的重点。更好地了解运动如何改善胰岛素抵抗可以揭示这种情况的发病机制,并为患者提供更有效的运动处方。
公共卫生相关性:美国的儿童和青少年仍然比上一代人吃得更多,锻炼得更少;这种营养过剩和缺乏运动的结合是肥胖流行的部分原因,肥胖可能会缩短年轻人的预期寿命。我们提出了一项研究来评估运动是否可以扭转肥胖对这一重要人群的一些有害影响,如果可以,它可能如何发挥作用。我们希望更好地了解运动如何帮助将导致对肥胖及其对儿童和青少年的影响的深入了解,以及为我们的儿科患者提供更有效的运动处方。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SHANA ERIN MCCORMACK其他文献
SHANA ERIN MCCORMACK的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SHANA ERIN MCCORMACK', 18)}}的其他基金
Phentermine/Topiramate in children, adolescents, and young adults with hypothalamic obesity: a pilot and feasibility study
芬特明/托吡酯治疗下丘脑肥胖儿童、青少年和年轻人:一项试点和可行性研究
- 批准号:
10734754 - 财政年份:2023
- 资助金额:
$ 4.01万 - 项目类别:
Intensive tailored exercise training with NAD+ precursor supplementation to improve muscle mass and fitness in adolescent and young adult survivors of hematopoietic stem cell transplantation
补充 NAD 前体的强化定制运动训练可改善造血干细胞移植的青少年和年轻成年幸存者的肌肉质量和体能
- 批准号:
10677009 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
Intensive tailored exercise training with NAD+ precursor supplementation to improve muscle mass and fitness in adolescent and young adult survivors of hematopoietic stem cell transplantation
补充 NAD 前体的强化定制运动训练可改善造血干细胞移植的青少年和年轻成年幸存者的肌肉质量和体能
- 批准号:
10269529 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
Intensive tailored exercise training with NAD+ precursor supplementation to improve muscle mass and fitness in adolescent and young adult survivors of hematopoietic stem cell transplantation
补充 NAD 前体的强化定制运动训练可改善造血干细胞移植的青少年和年轻成年幸存者的肌肉质量和体能
- 批准号:
10477388 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
NAD+ precursor supplementation with exercise training to improve aerobic capacity in Friedreich's Ataxia
通过运动训练补充 NAD 前体以提高弗里德赖希共济失调患者的有氧能力
- 批准号:
10543547 - 财政年份:2020
- 资助金额:
$ 4.01万 - 项目类别:
NAD+ precursor supplementation with exercise training to improve aerobic capacity in Friedreich's Ataxia
通过运动训练补充 NAD 前体以提高弗里德赖希共济失调患者的有氧能力
- 批准号:
10329962 - 财政年份:2020
- 资助金额:
$ 4.01万 - 项目类别:
Translational investigation of abnormal fat metabolism in mitochondrial disease
线粒体疾病中脂肪代谢异常的转化研究
- 批准号:
8890499 - 财政年份:2015
- 资助金额:
$ 4.01万 - 项目类别:
Translational investigation of abnormal fat metabolism in mitochondrial disease
线粒体疾病中脂肪代谢异常的转化研究
- 批准号:
9025785 - 财政年份:2015
- 资助金额:
$ 4.01万 - 项目类别:
相似海外基金
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10369750 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10633248 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10487516 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
Understanding and measuring the impact of stigma on PrEP adherence among adolescent girls and young women in Kenya: identifying targets for future interventions
了解和衡量耻辱对肯尼亚少女和年轻女性坚持 PrEP 的影响:确定未来干预措施的目标
- 批准号:
10220170 - 财政年份:2020
- 资助金额:
$ 4.01万 - 项目类别:
Understanding and measuring the impact of stigma on PrEP adherence among adolescent girls and young women in Kenya: identifying targets for future interventions
了解和衡量耻辱对肯尼亚少女和年轻女性坚持 PrEP 的影响:确定未来干预措施的目标
- 批准号:
10330076 - 财政年份:2020
- 资助金额:
$ 4.01万 - 项目类别:
Understanding and measuring the impact of stigma on PrEP adherence among adolescent girls and young women in Kenya: identifying targets for future interventions
了解和衡量耻辱对肯尼亚少女和年轻女性坚持 PrEP 的影响:确定未来干预措施的目标
- 批准号:
10054077 - 财政年份:2020
- 资助金额:
$ 4.01万 - 项目类别:
Investigating Pathways to Medication (Non)Adherence in Adolescent Solid Organ Transplant Patients
调查青少年实体器官移植患者药物(非)依从性的途径
- 批准号:
9758859 - 财政年份:2019
- 资助金额:
$ 4.01万 - 项目类别:
Combining PrEP with contraception: a pilot test of an intervention to increase adherence to PrEP in adolescent girls and young women in Zimbabwe
将 PrEP 与避孕相结合:一项旨在提高津巴布韦少女和年轻女性对 PrEP 依从性的干预措施试点测试
- 批准号:
10018645 - 财政年份:2019
- 资助金额:
$ 4.01万 - 项目类别:
Social and psychological predictors of PrEP adherence among adolescent girls and young women in Eastern and Southern Africa
东部和南部非洲少女和年轻女性坚持 PrEP 的社会和心理预测因素
- 批准号:
10087797 - 财政年份:2019
- 资助金额:
$ 4.01万 - 项目类别:
Combining PrEP with contraception: a pilot test of an intervention to increase adherence to PrEP in adolescent girls and young women in Zimbabwe
将 PrEP 与避孕相结合:一项旨在提高津巴布韦少女和年轻女性对 PrEP 依从性的干预措施试点测试
- 批准号:
10224010 - 财政年份:2019
- 资助金额:
$ 4.01万 - 项目类别:














{{item.name}}会员




