The Importance of Periostin in Periodontal Health and Disease

骨膜素在牙周健康和疾病中的重要性

• 批准号: 8104224
• 负责人: Hector F Rios
• 金额: $ 13.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-02 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8104224
• 关键词: Address; Adult; Algorithms; Alveolar; Alveolar Bone Loss; Applications Grants; Award; Basic Science; Biological Markers; Biology; Biostatistical Methods; Cells; Clinical; Clinical Research; Clinical Trials; Commit; Consent; Cytoskeleton; Data; Data Analyses; Dental; Development; Development Plans; Diagnosis; Disease; Disease Progression; Disease susceptibility; Educational Curriculum; Environment; Event; Fibroblasts; Foundations; Future; Gingival Crevicular Fluid; Goals; Growth Factor; Healed; Health; Heart; Homeostasis; Human; Human Development; Inflammatory; Integrins; Interleukins; Knockout Mice; Laboratories; Laboratory Finding; Learning; Liquid substance; Longitudinal Studies; Matrix Metalloproteinases; Measures; Mechanics; Modeling; Molecular; Molecular Biology; Morbidity - disease rate; Mouth Diseases; Myocardial Infarction; Natural regeneration; Oral health; Pathway interactions; Patients; Pattern; Peptide Hydrolases; Periodontal Diseases; Periodontal Ligament; Periodontic specialty; Periodontitis; Periodontium; Phenotype; Population; Positioning Attribute; Predisposition; Prevalence; Prevention; Probability Theory; Process; Property; Proteins; Public Health; Qualifying; Quality of life; Recovery; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Research Proposals; Research Training; Risk Factors; Role; Saliva; Scientist; Screening procedure; Secure; Serum; Signal Transduction; Solutions; Staging; Structure; Systemic disease; Time; Tissues; Tooth Loss; Tooth structure; Training; Transforming Growth Factors; Translating; Validation; Wound Healing; base; career; career development; clinically relevant; cytokine; design; healing; high standard; innovation; insight; longitudinal analysis; microbial; microorganism; modifiable risk; mortality; novel; oral biology; pathogen; patient oriented research; periostin; practical application; predictive modeling; public health relevance; receptor; repaired; response; response to injury; sample collection; skills; tool; wound

DESCRIPTION (provided by applicant): The candidate's background in Oral and Molecular Biology as well as his training in Periodontics equips him with the tools to explore innovative approaches to understand and address clinically relevant health problems. The training and the research proposed in this application are designed to increase his investigating skills to translate important laboratory findings into the clinical arena, with the ultimate goal of developing into an independent clinical and translational scientist. In the Years 1-2, the proposed curriculum will be completed. In Years 1-3, the research described will be conducted and the data will be utilized to prepare an R01 grant application. In humans, loss of periodontal integrity leading to periodontal destruction is known as periodontitis. It is known that periodontitis is triggered by specific periodontal pathogens in a susceptible host. However, the mechanism by which these microorganisms compromise the modulation of cell-matrix interactions is not clearly understood. The proteins modulating these interactions are known collectively as matricellular molecules. The goal of the research proposal is to study the importance of Periostin, a novel matricellular molecule and periodontal ligament marker, in periodontal health and disease. We have shown that Periostin null mice suffer severe alveolar bone loss over time resulting in tooth loss. We hypothesize that Periostin levels are decreased during periodontal disease, leading to increased host susceptibility to periodontal breakdown. The clinical validation of this finding is fundamental as it may trigger the development of innovative solutions that will ultimately help the patients. The proposed career development plan is designed to secure sufficient time to achieve two main objectives: 1) to gain additional training in the translational application of laboratory based research findings to clinical research, including further statistical training, and grantsmanship; and 2) to use the data collected and newly developed clinical research expertise to position him as a qualified candidate for a future independent investigator award in patient-oriented research. This project will allow Dr. Rios to further explore the possible relationship between Periostin and periodontal disease necessary for the development of human clinical trials. PUBLIC HEALTH RELEVANCE: The data generated will have important implications for our understanding of periodontal biology in the context of cell-matrix dynamics and their role in periodontal homeostasis. These studies may highlight novel pathways that determine periodontal disease susceptibility that could be targeted in the treatment of inflammatory periodontal diseases.

描述（由申请人提供）：候选人在口腔和分子生物学的背景，以及他在牙周病培训装备他的工具，探索创新的方法来理解和解决临床相关的健康问题。本申请中提出的培训和研究旨在提高他的调查技能，将重要的实验室发现转化为临床竞技场，最终目标是发展成为独立的临床和转化科学家。在1-2年级，将完成拟议的课程。在第1-3年，将进行所描述的研究，并将利用数据来准备R 01资助申请。在人类中，牙周完整性的丧失导致牙周破坏被称为牙周炎。众所周知，牙周炎是由易感宿主中的特定牙周病原体引发的。然而，这些微生物损害细胞-基质相互作用的调节的机制尚不清楚。调节这些相互作用的蛋白质统称为基质细胞分子。该研究计划的目标是研究Periostin，一种新型的基质细胞分子和牙周膜标记物，在牙周健康和疾病中的重要性。我们已经表明，无骨膜蛋白的小鼠随着时间的推移遭受严重的牙槽骨损失，导致牙齿损失。我们假设牙周病期间骨膜蛋白水平降低，导致宿主对牙周破裂的易感性增加。这一发现的临床验证是至关重要的，因为它可能会引发创新解决方案的开发，最终帮助患者。拟议的职业发展计划旨在确保有足够的时间实现两个主要目标：1）获得将实验室研究成果转化为临床研究的额外培训，包括进一步的统计培训和培训;和2）使用收集的数据和新开发的临床研究专业知识，将他定位为未来独立研究者奖的合格候选人，以病人为中心的研究。该项目将使Rios博士能够进一步探索Periostin与牙周病之间的可能关系，这对于人类临床试验的发展是必要的。 公共卫生关系：所产生的数据将有重要的意义，我们了解牙周生物学的背景下，细胞基质动力学和牙周的稳态中的作用。这些研究可能会突出新的途径，确定牙周病的易感性，可以在炎症性牙周病的治疗目标。