Importance of Periostin in Periodontal Homeostasis and Pathogenesis

Periostin 在牙周稳态和发病机制中的重要性

• 批准号: 8703878
• 负责人: Hector F Rios
• 金额: $ 31.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-04 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8703878
• 关键词: Address; Adult; Affect; Bacteria; Binding; Biological Markers; Biology; Biomechanics; Cell Proliferation; Cells; Chronic; Clinical; Complex; Connective Tissue; Dentists; Development; Disease; Eating; Epithelial; Epithelium; Etiology; Event; Fibroblasts; Goals; Health; Health Transition; Homeostasis; Individual; Inflammation; Inflammatory; Integrins; Knowledge; Lead; Maintenance; Mechanical Stimulation; Mechanical Stress; Mechanics; Mesenchymal; Michigan; Mining; Molecular; Molecular Biology; Pathogenesis; Patients; Peptide Hydrolases; Periodontal Diseases; Periodontitis; Periodontium; Physiological; Population; Predisposition; Prevention; Property; Proteins; Regulation; Research; Risk; Role; Signs and Symptoms; Stimulus; Time; Tissues; Tooth structure; United States; Universities; Work; base; bone; cell motility; cytokine; in vivo; insight; molecular dynamics; novel; pathogen; periostin; practical application; pre-clinical; receptor; response; successful intervention

DESCRIPTION (provided by applicant): Periodontal diseases affect a large proportion of the world's population. New insights into periodontal disease pathogenesis should incorporate the molecular biology dynamics that the periodontium undergoes in response to bacteria and chronic periodontal inflammation. Understanding this sequence of events allows us to delineate important clinical implications that would enable us to determine disease activity while increasing our understanding of the molecular networks behind the patient's susceptibility to periodontal breakdown. Periostin is a matricellular protein relevant for tissue integrity and maturation and is believed to have a function in the periodontium. We hypothesize that Periostin levels are important for proper periodontal homeostasis and periodontal disease pathogenesis and propose conducting studies on the role of Periostin in periodontal function and disease with the following specific aims: Specific Aim 1- To determine the biomechanical mechanism of Periostin regulation. Specific Aim 2- To evaluate the effect of periodontal bacteria and proinflammatory cytokines on Periostin levels. Specific Aim 3- To analyze the protective role of Periostin on periodontal stability in-vivo. Molecules such as Periostin serve as potential novel biomarkers with significant implications to aid in our understanding of periodontal biology relevant to cell-matrix dynamics and homeostasis. Collectively, the available evidence and evolving understanding of the molecular dynamics that determine a patient's susceptibility to periodontal breakdown triggered by periodontal pathogens would assist clinicians on the complex task of identifying important etiologic contributors that could be targeted in the treatment of inflammatory periodontal diseases.

描述（由申请人提供）：牙周病影响世界人口的很大一部分。牙周病发病机制的新见解应该包括牙周组织在细菌和慢性牙周炎症反应中所经历的分子生物学动力学。了解这一系列的事件使我们能够描绘重要的临床意义，使我们能够确定疾病的活动，同时增加我们的理解的分子网络背后的患者的易感性牙周破裂。骨膜蛋白是与组织完整性和成熟相关的基质细胞蛋白，并且被认为在牙周组织中具有功能。我们假设骨膜蛋白水平对于适当的牙周稳态和牙周病发病机制是重要的，并建议进行骨膜蛋白在牙周功能和疾病中的作用的研究，具体目标如下：具体目标1-确定骨膜蛋白调节的生物力学机制。具体目标2-评估牙周细菌和促炎细胞因子对骨膜蛋白水平的影响。具体目标3-分析Periostin对体内牙周稳定性的保护作用。骨膜蛋白等分子作为潜在的新型生物标志物，具有重要意义，有助于我们了解与细胞基质动力学和稳态相关的牙周生物学。总的来说，现有的证据和不断发展的理解的分子动力学，确定患者的易感性牙周病菌引发的牙周破裂将有助于临床医生的复杂任务，确定重要的病因贡献者，可以有针对性地治疗炎症性牙周疾病。