Infant Stress Response: Effects of Maternal PTSD and Infant Genes

婴儿应激反应：母亲 PTSD 和婴儿基因的影响

• 批准号: 8096689
• 负责人: Maria Muzik
• 金额: $ 17.87万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-22 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8096689
• 关键词: Address; Adult; Alleles; Animal Experimentation; Anxiety; Arousal; Autonomic nervous system; Behavior; Behavioral Mechanisms; Biological; Birth; Child; Clinical; Clinical Research; Complex; Corticotropin-Releasing Hormone Receptors; Critical Pathways; Data; Development; Diagnosis; Disease; Distress; Dopamine; Education; Educational process of instructing; Environment; Environmental Risk Factor; Face; Foundations; Funding; Future; Gene Expression; Generations; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Genetic Risk; Genotype; Glucocorticoid Receptor; Goals; Human; Hydrocortisone; Infant; Infant Behavior; Infant Development; Knowledge; Laboratories; Link; Literature; Maternal Behavior; Mediating; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Michigan; Modeling; Mothers; Neurobiology; Neurosecretory Systems; Outcome; Pathway interactions; Physiological; Play; Population; Post-Traumatic Stress Disorders; Postpartum Period; Psychopathology; Psychophysiology; Recruitment Activity; Regulation; Relative (related person); Research; Research Design; Research Methodology; Research Personnel; Risk; Role; Sampling; Scientist; Serotonin; Shapes; Social Interaction; Stress; System; Testing; Training; Trauma; Universities; Variant; Work; behavior measurement; beta-2 Adrenergic Receptors; biological adaptation to stress; biological research; biological systems; career; caregiving; deviant; dopamine D4 receptor; emotional distress; experience; genetic risk factor; heart rate variability; high risk; hypothalamic-pituitary-adrenal axis; infant outcome; innovation; intergenerational; model development; offspring; prenatal; prenatal influence; prenatal stress; programs; promoter; receptor; resilience; response; serotonin transporter; skills; success; transmission process

DESCRIPTION (provided by applicant): The goal of this Mentored Research Career Award (K23) application is to provide training and innovative models for research on the biological, genetic and behavioral mechanisms underlying the intergenerational transmission of psychiatric risk from mother to infant. The training will provide (1) advanced education in clinical and biological research methodology, and (2) extensive, mentored research experience in assessment and interpretation of neurobiological and genetic data. The training components will include formal coursework in the University of Michigan Clinical Research Design and Statistical Analysis Program (CRDSA) under the Michigan CTSA, and extended laboratory experiences through the University of Michigan Genetics Laboratory and Trauma, Stress, and Anxiety Research Group's neurobiological and psycho-physiological laboratories. Models will be developed to study intergenerational transmission of risk, focusing on mothers with PTSD, infant's genetic risk factors, and their impact on infants' neurobiological stress regulation. Two-hundred mothers (100 PTSD-positive and 100 trauma-exposed PTSD-negative) and their 7-month old infants will be studied. Infants will be genotyped for the "risk" allele polymorphisms on the serotonin transporter promoter gene, which has been robustly identified in the current literature as related to unique variation in capacity for distress regulation. Mother-infant dyads will be studied in several low-and high challenge interactions (Free Play, Teaching Task, and Still Face Paradigm) with measurement of behavioral and neurobiological stress responses (cortisol, heart rate variability). We hypothesize that (1) maternal PTSD will predict less optimal infant neurobiological stress regulation, and this link will be mediated by maternal behavior; (2) presence of genetic "risk" in the infant will predict less optimal infant neurobiological stress regulation, and this relation will be moderated by maternal behavior. The combination of didactic training, mentored research experience and model development will provide the applicant with the knowledge, skills, and high quality preliminary data needed for the subsequent success as an independently funded clinical scientist, studying the complex, transactional, and longitudinal pathways of intergenerational risk transmission.

描述（由申请人提供）：本指导研究职业奖（K23）申请的目标是为研究精神风险从母亲到婴儿的代际传播的生物、遗传和行为机制提供培训和创新模型。培训将提供（1）临床和生物学研究方法方面的高级教育，以及（2）在神经生物学和遗传数据的评估和解释方面广泛的、受指导的研究经验。培训内容将包括密歇根大学 CTSA 下的密歇根大学临床研究设计和统计分析计划 (CRDSA) 的正式课程，以及通过密歇根大学遗传学实验室和创伤、压力和焦虑研究小组的神经生物学和心理生理实验室扩展实验室经验。将开发模型来研究风险的代际传播，重点关注患有创伤后应激障碍的母亲、婴儿的遗传风险因素及其对婴儿神经生物应激调节的影响。将对 200 名母亲（100 名 PTSD 阳性和 100 名遭受创伤的 PTSD 阴性）及其 7 个月大的婴儿进行研究。将对婴儿的血清素转运蛋白启动子基因上的“风险”等位基因多态性进行基因分型，该基因已在当前文献中被有力地鉴定为与应激调节能力的独特变异有关。将通过几种低挑战和高挑战互动（自由游戏、教学任务和静止面孔范式）来研究母婴二人组，并测量行为和神经生物学压力反应（皮质醇、心率变异性）。我们假设（1）母亲的 PTSD 将预测不太理想的婴儿神经生物学应激调节，并且这种联系将由母亲行为介导； (2) 婴儿中存在遗传“风险”将预测婴儿神经生物学应激调节不太理想，并且这种关系将受到母亲行为的调节。教学培训、指导研究经验和模型开发的结合将为申请人提供知识、技能和高质量的初步数据，以便申请人随后成为一名独立资助的临床科学家，研究代际风险传递的复杂、交易和纵向路径。

项目成果

Rapid Anxiety and Depression Diagnosis in Young Children Enabled by Wearable Sensors and Machine Learning.

通过可穿戴传感器和机器学习实现幼儿焦虑和抑郁的快速诊断。

• DOI: 10.1109/embc.2018.8513327
• 发表时间: 2018
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: McGinnis,RyanS;McGinnis,EllenW;Hruschak,Jessica;Lopez-Duran,NestorL;Fitzgerald,Kate;Rosenblum,KatherineL;Muzik,Maria
• 通讯作者: Muzik,Maria

Digital Phenotype for Childhood Internalizing Disorders: Less Positive Play and Promise for a Brief Assessment Battery.

• DOI: 10.1109/jbhi.2021.3053846
• 发表时间: 2021-08
• 期刊: IEEE journal of biomedical and health informatics
• 影响因子: 7.7
• 作者: McGinnis EW;Scism J;Hruschak J;Muzik M;Rosenblum KL;Fitzgerald K;Copeland W;McGinnis RS
• 通讯作者: McGinnis RS

Childhood adversity and sleep are associated with symptom severity in perinatal women presenting for psychiatric care.

• DOI: 10.1007/s00737-018-0914-2
• 发表时间: 2019-08
• 期刊: Archives of women's mental health
• 作者: Menke RA;Swanson L;Erickson NL;Reglan G;Thompson S;Bullard KH;Rosenblum K;Lopez JP;Muzik M;WIMH Group at University of Michigan
• 通讯作者: WIMH Group at University of Michigan

The Association of Religion and Spirituality with Postpartum Mental Health in Women with Childhood Maltreatment Histories.

• DOI: 10.1007/s10826-019-01595-2
• 发表时间: 2020-02
• 期刊: Journal of child and family studies
• 影响因子: 2.1
• 作者: Handelzalts JE;Stringer MK;Menke RA;Muzik M
• 通讯作者: Muzik M

Maternal Postpartum Depression Increases Vulnerability for Toddler Behavior Problems through Infant Cortisol Reactivity.

母亲产后抑郁症通过婴儿皮质醇反应增加幼儿行为问题的脆弱性。

• DOI: 10.1111/infa.12271
• 发表时间: 2019
• 期刊: Infancy : the official journal of the International Society on Infant Studies
• 作者: Lawler,JamieM;Bocknek,ErikaL;McGinnis,EllenW;Martinez-Torteya,Cecilia;Rosenblum,KatherineL;Muzik,Maria
• 通讯作者: Muzik,Maria