Phenomenology of Obsessive Compulsive Personality Disorder

强迫性人格障碍的现象学

• 批准号: 8105233
• 负责人: Anthony Pinto
• 金额: $ 18.52万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-08 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8105233
• 关键词: Address; Affect; Anorexia Nervosa; Anxiety; Area; Attention; Back; Behavior; Classification; Clinical; Clinical Trials; Cognitive; Cognitive remediation; Communities; Data; Decision Making; Development; Diagnosis; Diagnostic; Dimensions; Disease; Doctor of Philosophy; Evidence based treatment; Family; Five-Year Plans; Funding; Future; Goals; Grant; Heterogeneity; Hybrids; Individual; Intervention; Interview; Knowledge; Lead; Link; Manuscripts; Measures; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Modeling; Nature; Neurocognition; Neurocognitive; Neuropsychology; Obsessive-Compulsive Disorder; Obsessive-Compulsive Personality; Outcome Measure; Pathology; Patients; Personality; Personality Disorders; Personality Traits; Public Health; Quality of life; Research; Research Ethics; Research Personnel; Research Project Grants; Sampling; Severities; Structure; Symptoms; Testing; Time; Training Activity; Writing; career; career development; design; executive function; functional disability; improved; instrument; neurocognitive test; neuropsychological; novel; novel therapeutics; patient oriented research; programs; psychosocial; public health relevance; response; skills; success; trait; treatment trial

DESCRIPTION (provided by applicant): The proposed Mentored Patient-Oriented Research Career Development Award (K23) is a five-year plan that will enable the candidate to develop his career as a clinical researcher with a programmatic line of research in the area of obsessive compulsive personality disorder (OCPD). The application integrates formal coursework, complementary mentorship under established researchers, and an independent research program that will enable the candidate to: (1) develop expertise in the phenomenology of OCPD and personality disorder assessment; (2) become proficient in the neuropsychological assessment of executive functioning; (3) increase his knowledge of clinical trial methodology/research ethics so that he can examine novel therapeutics for OCPD; and (4) enhance his manuscript- and grant-writing skills in order to establish an independently-funded OCPD research program. In addition to mentored training activities, the candidate also proposes three research projects, each designed to advance the study of OCPD by filling specific gaps in our understanding of the disorder. In Project 1, the candidate will systematically examine the phenomenology of OCPD, particularly its core dimensions, psychosocial functioning (from both the patient and family perspective), and the controversial relationship with obsessive compulsive disorder (OCD). The candidate will develop much needed clinical instruments for the disorder, including a checklist of OCPD traits and symptomatic behaviors for characterization and a semi-structured interview to assess severity, both of which will facilitate further research. Project 2 will be the first comprehensive study of hypothesized executive deficits in OCPD (versus controls), namely cognitive inflexibility and overattention to details, using neurocognitive tests of set-shifting, response inhibition, decision making, and planning. To clarify the convergence of OCPD and OCD, the clinical and neurocognitive measures will be administered to OCPD subjects with and without comorbid OCD. Project 3 will test whether a novel intervention, cognitive remediation therapy, with demonstrated success in anorexia nervosa and OCD, leads to improvement in OCPD severity, as well as executive and psychosocial functioning. Public Health Relevance: OCPD is an impairing yet poorly understood personality disorder. Even though it is one of the most frequently diagnosed personality disorders across community and clinical samples, OCPD has received little empirical attention in the last two decades and there are currently no evidence-based treatments for the disorder. The proposed research is expected to have substantial clinical and public health significance because it will provide the necessary groundwork in phenomenology, assessment, and neurocognition to develop new treatments. In addition, the neurocognitive data will offer a first step in understanding potential underlying mechanisms, and the open trial will provide the first test of a novel intervention in this patient group.

描述（由申请人提供）：拟议的以患者为导向的研究职业发展奖（K23）是一个五年计划，将使候选人能够发展自己作为临床研究人员的职业生涯，在强迫性人格障碍（OCPD）领域进行规划性研究。该应用程序整合了正式课程、知名研究人员的补充指导以及独立研究项目，使候选人能够：（1）发展 OCPD 现象学和人格障碍评估方面的专业知识； (2) 精通执行功能的神经心理学评估； (3) 增加他对临床试验方法/研究伦理的了解，以便他能够研究 OCPD 的新疗法； (4) 提高他的手稿和资助写作技巧，以便建立一个独立资助的 OCPD 研究项目。除了指导培训活动外，候选人还提出了三个研究项目，每个项目都旨在通过填补我们对该疾病理解的具体空白来推进对 OCPD 的研究。在项目 1 中，候选人将系统地研究 OCPD 的现象学，特别是其核心维度、心理社会功能（从患者和家庭的角度）以及与强迫症 (OCD) 之间有争议的关系。候选人将为该疾病开发急需的临床工具，包括用于表征的 OCPD 特征和症状行为清单以及用于评估严重程度的半结构化访谈，这两者都将促进进一步的研究。项目 2 将是第一个对假设的 OCPD 执行缺陷（与对照）进行全面研究，即认知僵化和对细节的过度关注，使用设定转移、反应抑制、决策和计划的神经认知测试。为了阐明 OCPD 和 OCD 的共同点，将对患有或不患有 OCD 共病的 OCPD 受试者进行临床和神经认知测量。项目 3 将测试一种新的干预措施——认知补救疗法，在神经性厌食症和强迫症方面取得了成功，是否可以改善强迫症的严重程度以及执行和社会心理功能。公共健康相关性：OCPD 是一种损害性但人们对其知之甚少的人格障碍。尽管 OCPD 是社区和临床样本中最常诊断出的人格障碍之一，但在过去二十年中，它很少受到实证关注，而且目前还没有针对该疾病的循证治疗方法。拟议的研究预计将具有重大的临床和公共卫生意义，因为它将为现象学、评估和神经认知方面的新疗法的开发提供必要的基础。此外，神经认知数据将为理解潜在的潜在机制提供第一步，而开放试验将为该患者群体提供新型干预措施的首次测试。