Body Size, Physical Activity and Breast Cancer Subtypes

体型、体力活动和乳腺癌亚型

• 批准号: 8174233
• 负责人: Lynn Rosenberg
• 金额: $ 21.25万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174233
• 关键词: Affect; African; African American; Age; American; Body Size; Body mass index; Breast Cancer Epidemiology; Central obesity; DNA; Diagnosis; Etiology; European; Exercise; Gene Expression Profiling; Genetic; Health; Incidence; Inflammation; Insulin; Insulin-Like Growth Factor I; Intervention; Joints; Lead; Longevity; Malignant Neoplasms; Measures; Meta-Analysis; Nature; Obesity; Pathway interactions; Physical activity; Premenopause; Risk; SNP genotyping; Sampling; Study Subject; Time; Waist-Hip Ratio; Woman; Women' s Health; base; cancer health disparity; cohort; early onset; epidemiologic data; genetic variant; interest; malignant breast neoplasm; mortality; reproductive; sedentary; steroid hormone; tumor

American women of African ancestry (AA) are affected with more aggressive breast cancers and at younger ages than women of European ancestry (EA). Increasing evidence indicates that subtypes of breast cancer have different etiologies, and there are suggestive epidemiologic data regarding the relation of body size and physical activity to incidence of breast cancer subtypes (e.g., positive association of waist-hip ratio with basal-like cancer). AA women are more often obese and sedentary than EA women, differences that could be contributing to the observed breast cancer disparities. We will assess associations of body size and physical activity with subtypes of breast cancer by pooling data and DNA samples from four large studies of breast cancer in AA women: the Black Women's Health Study, the Carolina Breast Cancer Study, the Women's Circle of Health Study, and the Multi-ethnic Cohort. We propose to assess measures of body size, including overall obesity, abdominal obesity, and body mass index at age 18, and measures of physical activity at different times during the lifespan, in relation to incidence of breast cancer subtypes, including ER- /PR-, five intrinsic subtypes, and early onset breast cancer. Based on study subjects' DNA, we will genotype SNPs in the insulin and IGF-1 pathways, assess their association with the subtypes of breast cancer, and then assess the joint effects of body size and physical activity with the genetic variants on risk of the subtypes. Hypotheses of particular interest are that high WHR is associated with increased incidence of ER- /PR- and basal-like cancer, high body mass index with decreased incidence of premenopausal luminal A cancer, and physical activity, particularly in early reproductive years, with decreased incidence of ER-/PR- and basal-like cancer. In cross project aims, we will assess the modifying effects of genetic variants associated with breast cancer in Project 2 in the steroid hormone pathway and Project 4 in the inflammation pathway on the associations of body size and physical activity with breast cancer subtypes. This study has excellent power to achieve the proposed aims. The study will add appreciably to understanding of the etiology of aggressive breast cancers. It is particularly important to establish the nature of the associations of body size and physical activity with risk of breast cancer because these factors are modifiable.

非洲裔美国女性更易患侵袭性乳腺癌，而且发病年龄更小