A Follow-up Study for Causes of Cancer in Black Women

描述（由申请人提供）：黑人妇女健康研究（BWHS）是非洲裔美国人（AA）妇女癌症的最大随访研究，始于1995年，当时来自美国各地的59，000名妇女（中位年龄为38岁）参加。BWHS已经成功地跟踪了参与者，每两年进行一次问卷调查，以获取有关事件疾病和医疗，生殖，行为，心理社会和社会经济因素的数据，将地址与美国人口普查数据联系起来，目前正在与空气污染数据联系起来。癌症诊断由医院和癌症登记处的病理学数据验证。通过从26，800名参与者中收集脸颊细胞样本，建立了DNA生物储存库。尽管由于参与者在入学时年龄较小，癌症的发病率最初增长缓慢，但BWHS已广泛发表了关于乳腺癌风险因素的文章;目前已有足够的肺癌、结直肠癌和结肠腺瘤病例。我们建议：（1）继续跟踪/收集数据;（2）建立一个17 800份血液样本的储存库;（3）在联盟项目中分享数据/样本。BWHS的继续是非常可取的：90%的参与者仍然没有癌症;随访是成功的和公正的;队列已经达到癌症发病率显著增加的年龄;暴露的影响（例如，严重肥胖，种族主义），在其他人群中不太常见; DNA遗传癌症研究作出了宝贵的贡献，是一个主要的复制来源的研究乳腺癌和相关的表型在AA和其他群体; BWHS是一个关键的贡献者财团项目的罕见癌症在/\A;和BWHS一直是高产。由于许多血液标志物的水平是不利的AAs和一些研究的血液生物标志物与癌症的发病率已经进行了具体的/\As，我们建议建立一个储存库的血液样本中的BWHS。一项成功的试点研究表明，我们的方法和参与的可行性是公正的，类似于其他大型后续研究。该储存库将使美国癌症队列研究中有限数量的AA女性增加60%。AA妇女继续不成比例地受到许多癌症的影响。BWHS的继续将允许继续其宝贵的贡献，了解癌症病因学在这一研究不足的群体。血液储存库将通过允许有助于填补关于生物标志物与AA中癌症发病率和存活率的关系的知识空白的研究，大大增加BWHS资源的价值。对BWHS中严重非恶性疾病的评估提高了这一资源的价值，而对癌症的研究没有任何成本。

DESCRIPTION (provided by applicant): The Black Women's Health Study (BWHS), the largest follow-up study for cancer in African American (AA) women, began in 1995 when 59,000 women (median age, 38) from across the U.S. enrolled. The BWHS has successfully followed participants with biennial questionnaires for data on incident disease and medical, reproductive, behavioral, psychosocial, and socioeconomic factors, linked addresses to U.S. census data, and are currently linking to air pollution data. Cancer diagnoses are validated by pathology data from hospitals and cancer registries. A DNA bio repository was established through collection of cheek cell samples from 26,800 participants. Despite initial slow accrual of cancers due to the young age of participants at entry, the BWHS has published extensively on risk factors for breast cancer; sufficient cases of lung cancer, colorectal cancer, and colon adenomas are now available. We propose to (1) continue follow-up/data collection; (2) establish a repository of 17,800 blood samples; (3) share data/samples in consortia projects. Continuation of the BWHS is highly desirable: 90% of participants are still cancer-free; follow-up has been successful and unbiased; the cohort has reached ages at which cancer incidence increases markedly; effects of exposures (e.g., severe obesity, racism) that are less common in other populations can be studied; the DNA has made valuable contributions to genetic cancer studies and is a major replication source for studies of breast cancer and related phenotypes in AA and other groups; the BWHS is a key contributor to consortia projects of rarer cancers in /\As; and the BWHS has been highly productive. Because levels of many blood markers are unfavorable among AAs and few studies of blood biomarkers in relation to cancer incidence have been carried out specifically in /\As, we propose to establish a repository of blood samples in the BWHS. A successful pilot study demonstrated the feasibility of our methods and participation was unbiased and similar to that in other large follow-up studies. The repository will increase by 60% the limited number of AA women with available blood samples being followed in U.S. cancer cohort studies. AA women continue to be disproportionately affected by many cancers. Continuation of the BWHS will permit continuation of its valuable contributions to understanding cancer etiology in this understudied group. A blood repository will greatly increase the value of the BWHS resource by permitting studies that help to fill the knowledge gap about the relation of biomarkers to cancer incidence and survival in AAs. The assessment of serious nonmalignant illnesses in the BWHS enhances the value of this resource at no cost to the study of cancer.