A Follow-up Study for Causes of Cancer in Black Women

黑人女性癌症病因的后续研究

• 批准号: 8383511
• 负责人: Lynn Rosenberg
• 金额: $ 257.43万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8383511
• 关键词: 21 year old; Address; Affect; African American; Age; Air Pollution; Aliquot; Behavioral; Biological Markers; Blood; Blood specimen; Breast Cancer Risk Factor; Cancer Etiology; Cause of Death; Cells; Censuses; Cessation of life; Cheek structure; Cohort Studies; Collaborations; Collection; Colonic Adenoma; Colorectal Adenoma; Colorectal Cancer; Consent; DNA; Data; Data Analyses; Data Collection; Diagnostic; Disease; Education; Enrollment; Funding; Genotype; Health; Hospitals; Incidence; Income; Knowledge; Laboratories; Link; Mails; Malignant Neoplasms; Malignant neoplasm of lung; Manuscripts; Medical; Medical Records; Methods; Morbid Obesity; Newsletter; Non-Malignant; Nonrespondent; Nurses' Health Study; Online Systems; Outcome; Participant; Pathology; Patients; Phenotype; Pilot Projects; Population; Preparation; Prevalence; Process; Protocols documentation; Publishing; Quality Control; Questionnaires; Research; Resources; Risk; Risk Factors; Sampling; Scanning; Services; Shipping; Ships; Socioeconomic Factors; Source; Specific qualifier value; Woman; Women' s Health; abstracting; biobank; burden of illness; cancer diagnosis; cancer genetics; cohort; cost; data sharing; follow-up; genetic risk factor; health disparity; malignant breast neoplasm; mortality; neoplasm registry; non-genetic; payment; psychosocial; racism; repository; reproductive; response; success

DESCRIPTION (provided by applicant): The Black Women's Health Study (BWHS), the largest follow-up study for cancer in African American (AA) women, began in 1995 when 59,000 women (median age, 38) from across the U.S. enrolled. The BWHS has successfully followed participants with biennial questionnaires for data on incident disease and medical, reproductive, behavioral, psychosocial, and socioeconomic factors, linked addresses to U.S. census data, and are currently linking to air pollution data. Cancer diagnoses are validated by pathology data from hospitals and cancer registries. A DNA bio repository was established through collection of cheek cell samples from 26,800 participants. Despite initial slow accrual of cancers due to the young age of participants at entry, the BWHS has published extensively on risk factors for breast cancer; sufficient cases of lung cancer, colorectal cancer, and colon adenomas are now available. We propose to (1) continue follow-up/data collection; (2) establish a repository of 17,800 blood samples; (3) share data/samples in consortia projects. Continuation of the BWHS is highly desirable: 90% of participants are still cancer-free; follow-up has been successful and unbiased; the cohort has reached ages at which cancer incidence increases markedly; effects of exposures (e.g., severe obesity, racism) that are less common in other populations can be studied; the DNA has made valuable contributions to genetic cancer studies and is a major replication source for studies of breast cancer and related phenotypes in AA and other groups; the BWHS is a key contributor to consortia projects of rarer cancers in /\As; and the BWHS has been highly productive. Because levels of many blood markers are unfavorable among AAs and few studies of blood biomarkers in relation to cancer incidence have been carried out specifically in /\As, we propose to establish a repository of blood samples in the BWHS. A successful pilot study demonstrated the feasibility of our methods and participation was unbiased and similar to that in other large follow-up studies. The repository will increase by 60% the limited number of AA women with available blood samples being followed in U.S. cancer cohort studies. AA women continue to be disproportionately affected by many cancers. Continuation of the BWHS will permit continuation of its valuable contributions to understanding cancer etiology in this understudied group. A blood repository will greatly increase the value of the BWHS resource by permitting studies that help to fill the knowledge gap about the relation of biomarkers to cancer incidence and survival in AAs. The assessment of serious nonmalignant illnesses in the BWHS enhances the value of this resource at no cost to the study of cancer.

描述(由申请者提供)：黑人妇女健康研究(BWHS)是非洲裔美国人(AA)女性中最大的癌症后续研究，始于1995年，来自美国各地的59,000名女性(中位年龄，38岁)参加了研究。BWHS已经成功地对参与者进行了两年一次的问卷调查，调查了有关疾病事件和医疗、生殖、行为、心理和社会经济因素的数据，将地址与美国人口普查数据联系起来，目前正在与空气污染数据联系起来。癌症诊断是通过医院和癌症登记处的病理数据进行验证的。通过收集26,800名参与者的脸颊细胞样本，建立了DNA生物库。尽管最初由于参与者年龄较小，癌症进展缓慢，但BWHS已经就乳腺癌的风险因素发表了大量文章；现在可以获得足够的肺癌、结直肠癌和结肠腺瘤病例。我们建议(1)继续跟进/收集数据；(2)建立一个17,800个血液样本的储存库；(3)在联合体项目中共享数据/样本。BWHS的延续是非常可取的：90%的参与者仍然没有癌症；后续跟踪是成功和公正的；队列已经达到癌症发病率显著增加的年龄；可以研究在其他人群中不太常见的暴露(例如，严重肥胖、种族主义)的影响；DNA对遗传癌症研究做出了宝贵贡献，是AA和其他群体中乳腺癌和相关表型研究的主要复制来源；BWHS是AIN/\AS罕见癌症财团项目的关键贡献者；BWHS一直具有很高的生产力。由于许多血液标记物的水平在AAS中是不利的，而血液生物标记物与癌症发病率之间的关系的研究很少，因此我们建议在BWHS建立一个血液样本库。一项成功的初步研究证明了我们方法的可行性，参与是公正的，与其他大型后续研究类似。该资料库将使美国癌症队列研究中追踪可用血液样本的再生障碍性贫血妇女的有限数量增加60%。再生障碍性贫血妇女继续受到许多癌症的不成比例的影响。BWHS的继续将使其对了解这一未被研究的群体的癌症病因学的宝贵贡献继续下去。血库将极大地增加BWHS资源的价值，因为它允许进行有助于填补关于生物标记物与AAS癌症发病率和生存率关系的知识空白的研究。BWHS中对严重非恶性疾病的评估提高了这一资源的价值，而不需要花费任何费用来研究癌症。