COPD EPIDEMIOLOGY WHOLE GENOME ANALYSIS PROJECT

慢性阻塞性肺病流行病学全基因组分析项目

• 批准号: 8166873
• 负责人: JOE WESLEY RAMSDELL
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166873
• 关键词: Chronic Obstructive Airway Disease; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Epidemiology; Funding; Genes; Genetic Determinism; Genome; Goals; Grant; Institution; Measures; Physiological; Predisposition; Pulmonary Emphysema; Research; Research Personnel; Resources; Site; Source; Syndrome; United States National Institutes of Health; X-Ray Computed Tomography; clinically relevant; clinically significant; genome wide association study; insight

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. UCSD will participate as one site in a multi center trial with the overall goal of conducting a comprehensive genome-wide association (GWA) study to identify genes influencing COPD. A list of all participating sites and the investigators is in Appendix A. Our primary hypotheses are: 1) Precise characterization of COPD subjects using computed tomography, as well as clinical and physiological measures, will provide insight that will enable the broad COPD syndrome to be decomposed into clinically significant subtypes. 2) Genome-wide association studies will identify genetic determinants for COPD susceptibility that will provide insight into clinically relevant COPD subtypes. 3) Distinct genetic determinants influence the development of emphysema and airway disease.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 加州大学圣地亚哥分校将作为一个中心参与一项多中心试验，总体目标是进行一项全面的全基因组关联 (GWA) 研究，以确定影响慢性阻塞性肺病的基因。 所有参与地点和研究者的列表见附录 A。 我们的主要假设是： 1) 使用计算机断层扫描以及临床和生理测量对 COPD 受试者进行精确表征，将提供深入见解，使广泛的 COPD 综合征能够分解为具有临床意义的亚型。 2) 全基因组关联研究将确定 COPD 易感性的遗传决定因素，从而深入了解临床相关的 COPD 亚型。 3) 不同的遗传决定因素影响肺气肿和气道疾病的发展。