PREVENTION OF LUNG FUNCTION DECLINE WITH VITAMIN E AND SELENIUM RESPIRATORY ANCI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 SELECT项目是一项多中心随机前瞻性临床试验，旨在评估硒和维生素E单独和联合使用对前列腺癌临床发病率的影响。RAS(IRB&#35；11798-01)是选择的辅助研究，因此完全在选择结构内进行。RAS通过收集选定参与者子集的一些额外医疗信息来实现其目标。RAS研究点是18个选定的研究点。RAS将针对所有参与者或部分参与者，具体取决于选定的地点。RAS参与者必须是一名积极的选定参与者，并在注册到RAS时服用补充剂。 RAS的总体目标是了解补充抗氧化剂是否可以减缓随着年龄增长而自然发生的肺功能丧失。这对吸烟者尤其重要，随着年龄的增长，他们的肺功能会更快地丧失。潜在参与者的知情同意和PHI授权是在他们首次访问时向RAS注册之前的要求。所有RAS参与者将被跟踪四年，在此期间将进行三次肺活量测试和一次血液样本采集(在选定的第三次年度访问中)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The SELECT project is a multicenter randomized prospective clinical trial to assess the effect of Selenium and Vitamin E alone and in combination on the clinical incidence of prostate cancer. The RAS (IRB# 11798-01) is an ancillary study to SELECT, thus it is carried out completely within the SELECT structure. The RAS achieves its aims through collecting some additional medical information on a subset of SELECT participants. The RAS study sites are the 18 SELECT study sites. The RAS will target all participants or some of the participants, depending on the SELECT site. RAS participants must be an active SELECT participant and on Supplements at the time of registration to RAS. The overall objective of the RAS is to understand whether supplemental antioxidants can slow the loss of lung function that occurs naturally with aging. This is particularly important for smokers, who have a more rapid loss of pulmonary function with increasing age. Informed consent and PHI authorization from potential participants is a requirement prior to registration to RAS at their initial visit. All RAS participants will be followed for four years and three spirometry tests and one time blood sample collection (at the SELECT third annual visit) will be done during this period.