CLINICAL TRIAL: THE SELENIUM AND VITAMIN E CHEMOPREVENTION TRIAL (SELECT)

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 随着年龄的增长，男性可能会患上几种主要疾病。在美国，心脏病是45岁及以上男性最常见的死亡原因，其次是癌症。前列腺癌是男性最常见的主要非皮肤癌，其次是肺癌和结肠癌和直肠癌。如果这些疾病可以预防，男性可以预期活得更长、更健康。这项研究将试图找出服用硒和/或维生素E是否会降低患前列腺癌、肺癌和结肠癌、所有癌症和心脏病的风险。三项研究表明，在饮食中摄入硒和维生素E可能会对前列腺癌、肺癌和结肠癌提供一些保护。SELECT将包括来自美国各地中心的约32，400名男性，以进一步调查这一问题，并可能帮助改善55岁及以上男性（或50岁及以上非裔美国男性）的健康状况。研究将对男性进行7-12年的随访。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are several major diseases that men may get as they get older. In the United States, Heart disease is the most common cause of death in men age 45 and older, followed by cancer. Prostate cancer is the most commonly occurring major non-skin cancer in men, followed by lung cancer and cancers of the colon and rectum. If these diseases could be prevented, men could expect to live longer and healthier lives. This study will try to find out if taking selenium and/or vitamin E will reduce the risk of developing prostate cancer, lung and colon cancer, all cancers combined and heart disease. Three studies have suggested that taking selenium and vitamin E in the diet may offer some protection against cancer of the prostate, lung and colon. SELECT will include about 32,400 men from centers throughout the United States to investigate this further and possibly help improve the health of men age 55 and older (or age 50 and older for African American men). Men will be followed in the study for 7-12 years.