CHOLESTEROL EFFLUX FROM MACROPHAGES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的假设是：动脉粥样硬化病变相关泡沫细胞中储存的胆固醇酯的降解减弱，有助于动脉粥样硬化患者或动脉粥样硬化风险患者血清高密度脂蛋白颗粒胆固醇外流能力的降低，并与血管内皮功能下降有关。 本研究旨在评估血清胆固醇流出能力及其与高密度脂蛋白颗粒ApoAI/ApoAII比值、单核/巨噬细胞CEH表达及血管内皮功能的关系。 这将是一项横断面先导性研究，调查三组的胆固醇外流潜力、载脂蛋白AI/载脂蛋白II比率、胆固醇酯水解性表达和内皮功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of the study: Attenuated hydrolysis of stored cholesterol esters in atherosclerotic-lesion associated foam cells contributes to decreased cholesterol efflux capacity of serum HDL particles in patients with atherosclerosis or risk for atherosclerosis and is associated with decreased vascular endothelial function. The present research proposal aims to assess cholesterol efflux potential of serum, and its relationship to ApoAI / ApoAII ratio of HDL particles, monocyte/macrophage CEH expression and vascular endothelial function. This will be a cross-sectional pilot study investigating cholesterol efflux potential, ApoAI / ApoAII ratio, cholesterol ester hydrolysis expression, and endothelial function in three groups.