RENALASE EXPRESSION IN CKD

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Enhanced adrenergic vascular reactivity significantly contributes to hypertension and deterioration of renal function leading to chronic kidney disease (CKD). Renalase is a critical enzyme that is required for the metabolism of catecholamines and maintenance of blood pressure (BP). This project will test the hypothesis that renalase levels decrease with progressive CKD and that these decreased levels are associated with increased catecholamine levels. 1. To determine serum renalase levels in individuals with all stages of CKD. 2. To correlate serum renalase levels and the stage of CKD as well as estimated GFR. 3. To determine the relationship between serum renalase, catecholamine, and blood pressure.