RENALASE EXPRESSION IN CKD

CKD 中的肾酶表达

• 批准号: 7717057
• 负责人: SHOBHA GHOSH
• 金额: $ 1.02万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717057
• 关键词: Adrenergic Agents; Blood Pressure; Blood Vessels; Catecholamines; Chronic Kidney Failure; Computer Retrieval of Information on Scientific Projects Database; Deterioration; Enzymes; Funding; Grant; Hypertension; Individual; Institution; Maintenance; Metabolism; Renal function; Research; Research Personnel; Resources; Serum; Source; Staging; Testing; United States National Institutes of Health; adrenergic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Enhanced adrenergic vascular reactivity significantly contributes to hypertension and deterioration of renal function leading to chronic kidney disease (CKD). Renalase is a critical enzyme that is required for the metabolism of catecholamines and maintenance of blood pressure (BP). This project will test the hypothesis that renalase levels decrease with progressive CKD and that these decreased levels are associated with increased catecholamine levels. 1. To determine serum renalase levels in individuals with all stages of CKD. 2. To correlate serum renalase levels and the stage of CKD as well as estimated GFR. 3. To determine the relationship between serum renalase, catecholamine, and blood pressure.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 肾上腺素能血管反应性增强会显着导致高血压和肾功能恶化，从而导致慢性肾病（CKD）。肾酶是儿茶酚胺代谢和维持血压 (BP) 所需的关键酶。该项目将检验以下假设：肾酶水平随进展性 CKD 降低，并且这些降低的水平与儿茶酚胺水平升高相关。 1. 测定患有各个阶段 CKD 的个体的血清肾酶水平。 2. 将血清肾酶水平与 CKD 分期以及估计的 GFR 相关联。 3.测定血清肾酶、儿茶酚胺与血压的关系。