RENALASE EXPRESSION IN CKD

CKD 中的肾酶表达

• 批准号: 7717057
• 负责人: SHOBHA GHOSH
• 金额: $ 1.02万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717057
• 关键词: Adrenergic Agents; Blood Pressure; Blood Vessels; Catecholamines; Chronic Kidney Failure; Computer Retrieval of Information on Scientific Projects Database; Deterioration; Enzymes; Funding; Grant; Hypertension; Individual; Institution; Maintenance; Metabolism; Renal function; Research; Research Personnel; Resources; Serum; Source; Staging; Testing; United States National Institutes of Health; adrenergic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Enhanced adrenergic vascular reactivity significantly contributes to hypertension and deterioration of renal function leading to chronic kidney disease (CKD). Renalase is a critical enzyme that is required for the metabolism of catecholamines and maintenance of blood pressure (BP). This project will test the hypothesis that renalase levels decrease with progressive CKD and that these decreased levels are associated with increased catecholamine levels. 1. To determine serum renalase levels in individuals with all stages of CKD. 2. To correlate serum renalase levels and the stage of CKD as well as estimated GFR. 3. To determine the relationship between serum renalase, catecholamine, and blood pressure.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 增强的肾上腺素能血管反应性显著促进高血压和肾功能恶化，导致慢性肾病（CKD）。肾酶是代谢儿茶酚胺和维持血压（BP）所需的关键酶。该项目将检验肾酶水平随进展性CKD而降低以及这些降低的水平与升高的儿茶酚胺水平相关的假设。 1.测定CKD各期患者的血清肾酶水平。 2.将血清肾酶水平与CKD分期以及估计的GFR相关联。 3.探讨血清肾酶、儿茶酚胺与血压的关系。