CHOLESTEROL EFFLUX FROM MACROPHAGES

巨噬细胞中的胆固醇流出

• 批准号: 7950854
• 负责人: SHOBHA GHOSH
• 金额: $ 0.23万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950854
• 关键词: Arterial Fatty Streak; Atherosclerosis; Attenuated; Blood Vessels; Cholesterol; Cholesterol Esters; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Foam Cells; Funding; Grant; High Density Lipoproteins; Hydrolysis; Institution; Patients; Pilot Projects; Research; Research Personnel; Research Proposals; Resources; Risk; Serum; Source; United States National Institutes of Health; macrophage; monocyte; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of the study: Attenuated hydrolysis of stored cholesterol esters in atherosclerotic-lesion associated foam cells contributes to decreased cholesterol efflux capacity of serum HDL particles in patients with atherosclerosis or risk for atherosclerosis and is associated with decreased vascular endothelial function. The present research proposal aims to assess cholesterol efflux potential of serum, and its relationship to ApoAI / ApoAII ratio of HDL particles, monocyte/macrophage CEH expression and vascular endothelial function. This will be a cross-sectional pilot study investigating cholesterol efflux potential, ApoAI / ApoAII ratio, cholesterol ester hydrolysis expression, and endothelial function in three groups.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究假设：在动脉粥样硬化病变相关泡沫细胞中储存的胆固醇酯的减弱水解有助于降低动脉粥样硬化或动脉粥样硬化风险患者血清HDL颗粒的胆固醇流出能力，并与血管内皮功能降低相关。 本研究旨在评估血清胆固醇流出潜力，及其与HDL颗粒的ApoAI / ApoAII比值、单核细胞/巨噬细胞CEH表达和血管内皮功能的关系。 这将是一项横断面初步研究，研究三组中的胆固醇外排潜力、ApoAI / ApoAII比值、胆固醇酯水解表达和内皮功能。