MITOCHONDRIAL DISEASES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 本研究方案的目的是继续我对线粒体疾病的性质和患病率的三十年调查。 线粒体是细胞质内的细胞器，产生细胞功能所需的大部分能量。 线粒体实际上是生活在我们细胞内的半自主细菌。 大约30亿年前，在多细胞植物和动物进化之前，这些细菌作为共生体埋葬了我们细胞的祖细胞。 今天，这些线粒体是我们细胞不可或缺的一部分，没有它们我们就无法生存。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this research protocol is to continue my thirty year investigation of the nature and prevalence of mitochondrial disease. The mitochondria are organelles within the cytoplasm of our cells that produce most of the energy necessary for cellular function. The mitochondrial are in fact semi-autonomous bacteria living within our cells. These bacteria interred the progenitors of our cells as symbionts about three billion years ago, before multi-cellular plants and animals evolved. Today these mitochondria are an integral part of our cells without which we could not live.