MORPHINE PHARMACOKINETICS AND PHARMACODYNAMICS IN SICKLE CELL DISEASE
吗啡在镰状细胞病中的药代动力学和药效学
基本信息
- 批准号:8166575
- 负责人:
- 金额:$ 0.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-12-01 至 2010-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAfrican AmericanAgeAnalgesicsCardiovascular systemCaringChronicCognitiveCommunitiesComputer Retrieval of Information on Scientific Projects DatabaseDoseDrug KineticsFundingGenderGrantHealth PersonnelInstitutionMorphineOpiate AddictionOpiatesOpioidPain managementParticipantPatientsPerceptionPharmacodynamicsPilot ProjectsPopulationRaceResearchResearch PersonnelResourcesSickle CellSickle Cell AnemiaSourceSubstance Use DisorderUnited States National Institutes of HealthWeightaddictionchronic paindesignmorphine-3-glucuronidemorphine-6-glucuronideresponse
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Healthcare providers' perception of and concern regarding opiate addiction can be major barriers to appropriate care. Further, use of sometimes high doses of opiates for acute and chronic pain management in SCD has led to concerns of inappropriate opiate dependence and addiction.
This study address the lack of supportive evidence for determining appropriate opiate prescribing in SCD, we propose a basic pilot study to characterize the pharmacokinetics and pharmacodynamics of morphine in segments of our SCD population. This pilot study will greatly inform the sickle cell community and prepare the ground for larger scale trials of opioid use in SCD
To determine the pharmacokinetic (morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) and pharmacodynamic (subjective, cognitive, cardiovascular and analgesic) effects of morphine (IV and PO) using a dose response design in 3 groups:
1. Sickle cell disease patients not treated chronically with opioids,
2. Sickle cell disease patients receiving chronic opioid treatment,
3. Control African-American participants without substance use disorders or current opioid use matched by age, race, gender, and weight.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
医疗保健提供者对阿片类药物成瘾的看法和担忧可能是适当护理的主要障碍。此外,在SCD中使用有时高剂量的阿片类药物用于急性和慢性疼痛管理已经导致了对不适当的阿片类药物依赖和成瘾的担忧。
这项研究解决了缺乏支持性证据,以确定适当的阿片类药物处方在SCD,我们提出了一个基本的试点研究,以表征吗啡的药代动力学和药效学在我们的SCD人群的部分。 这项试点研究将大大告知镰状细胞社区,并为更大规模的阿片类药物用于SCD试验奠定基础
采用剂量反应设计,在3组中确定吗啡(IV和PO)的药代动力学(吗啡-3-葡糖苷酸(M3 G)和吗啡-6-葡糖苷酸(M6 G))和药效学(主观、认知、心血管和镇痛)效应:
1.未长期接受阿片类药物治疗的镰状细胞病患者,
2.接受长期阿片类药物治疗的镰状细胞病患者,
3.对照非裔美国人参与者没有物质使用障碍或目前使用阿片类药物,年龄,种族,性别和体重相匹配。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wally R Smith其他文献
Incidence, Prevalence, and Disease Management Impactability of High Utilization in an Adult Sickle Cell Medical Home
- DOI:
10.1182/blood-2023-187621 - 发表时间:
2023-11-02 - 期刊:
- 影响因子:
- 作者:
Wally R Smith;Daniel Sop;Yue May Zhang;Benjamin Jaworowski;Shirley Johnson - 通讯作者:
Shirley Johnson
Towards an Implicit Measure of Patient Engagement in Sickle Cell Disease: Relationships between Implicit Measures of Engagement and Previous Childhood Trauma Among Adolescents and Young Adults
- DOI:
10.1182/blood-2023-187552 - 发表时间:
2023-11-02 - 期刊:
- 影响因子:
- 作者:
Haylee Hartzog;Shirley Johnson;Rachel Walls;Yue May Zhang;Daniel Sop;Wally R Smith - 通讯作者:
Wally R Smith
Oxycodone Produces Antinociception, but Worsens Functional Behaviors, in Humanized Sickle Cell Disease Mice
- DOI:
10.1182/blood-2022-162675 - 发表时间:
2022-11-15 - 期刊:
- 影响因子:
- 作者:
Kennedy N Goldsborough;Molly Sonenklar;Kalpna Gupta;M Imad Damaj;Wally R Smith;Joyce Lloyd;Aron Lichtman - 通讯作者:
Aron Lichtman
A Patient-Centric Approach to Sickle Cell Disease Clinical Trials: Integrating Patient Perspectives in the RISE UP Phase 2/3 Trial of Mitapivat for Informed Protocol Design and Associated Patient Community Benefit
- DOI:
10.1182/blood-2023-186710 - 发表时间:
2023-11-02 - 期刊:
- 影响因子:
- 作者:
Charles R. Jonassaint;Blaze Armon Eppinger;Dominique Friend;Golie Lorenzo Green;Mia Robinson;Teonna Woolford;DeMitrious Wyant;Janie Davis;Abdulafeez Oluyadi;Ahmar U Zaidi;Holly John;Wally R Smith - 通讯作者:
Wally R Smith
“It Was Bootstrap All the Way”: Exploring the Barriers and Facilitators to the Development of Non-Hematology Sickle Cell Disease Experts in the United States
- DOI:
10.1182/blood-2024-203728 - 发表时间:
2024-11-05 - 期刊:
- 影响因子:
- 作者:
Francis W Coyne;Deirdra R Terrell;Valerie Lang;Ashley M Jenkins;Allison A. King;Wally R Smith - 通讯作者:
Wally R Smith
Wally R Smith的其他文献
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{{ truncateString('Wally R Smith', 18)}}的其他基金
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
使用患者导航仪增强羟基脲在镰状细胞病中的应用
- 批准号:
8268195 - 财政年份:2012
- 资助金额:
$ 0.82万 - 项目类别:
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
使用患者导航仪增强羟基脲在镰状细胞病中的应用
- 批准号:
8904700 - 财政年份:2012
- 资助金额:
$ 0.82万 - 项目类别:
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
使用患者导航仪增强羟基脲在镰状细胞病中的应用
- 批准号:
9116288 - 财政年份:2012
- 资助金额:
$ 0.82万 - 项目类别:
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
使用患者导航仪增强羟基脲在镰状细胞病中的应用
- 批准号:
8698808 - 财政年份:2012
- 资助金额:
$ 0.82万 - 项目类别:
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
使用患者导航仪增强羟基脲在镰状细胞病中的应用
- 批准号:
8529610 - 财政年份:2012
- 资助金额:
$ 0.82万 - 项目类别:
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
使用患者导航仪增强羟基脲在镰状细胞病中的应用
- 批准号:
9564278 - 财政年份:2012
- 资助金额:
$ 0.82万 - 项目类别:
Comparative Effectiveness of Virginia Coordinated Care versus the Traditional Saf
弗吉尼亚协调护理与传统 SAF 的效果比较
- 批准号:
8055657 - 财政年份:2010
- 资助金额:
$ 0.82万 - 项目类别:
Virginia Basic and Translational Research Program
弗吉尼亚基础和转化研究计划
- 批准号:
7916725 - 财政年份:2008
- 资助金额:
$ 0.82万 - 项目类别:
Virginia Basic and Translational Research Program
弗吉尼亚基础和转化研究计划
- 批准号:
7640493 - 财政年份:2008
- 资助金额:
$ 0.82万 - 项目类别:
Virginia Commonwealth University Sickle Cell Disease
弗吉尼亚联邦大学镰状细胞病
- 批准号:
7060251 - 财政年份:2006
- 资助金额:
$ 0.82万 - 项目类别:
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