ALCOHOLISM, GENES, AND HORMONES; TISSUE REPOSITORY

酗酒、基因和激素；

• 批准号: 8174453
• 负责人: Magdalena Uhart
• 金额: $ 0.12万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174453
• 关键词: Alcoholism; Blood specimen; Computer Retrieval of Information on Scientific Projects Database; DNA; Data; Databases; Disease; Environmental Risk Factor; Etiology; Funding; Future; Genes; Genetic; Gland; Grant; Hormones; Institution; Lead; Learning; Literature; Measures; Medical center; Molecular Genetics; Nervous system structure; Neurosecretory Systems; Protocols documentation; Publishing; Recommendation; Research; Research Ethics Committees; Research Personnel; Resources; Source; Specimen; Tissue Sample; Tissues; United States National Institutes of Health; alcohol sensitivity; lymphoblastoid cell line; novel diagnostics; repository

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In the study application, Pro00017519, we acknowledge that there may be analysis planned in the future regarding the data collected during this study. In addition, when the study was reviewed by the IRB, the Board strongly recommended that a separate IRB protocol be established to create a repository for future research. It was indicated that maximum benefit could be gained through the establishment of a separate repository protocol at CSMC for this study. Following the IRBs recommendation, we are proposing in our current application to establish a specimen/tissue and data repository. The current repository protocol will be established to collect, store and distribute specimens/tissue and/or data for future research. In the current protocol, the study team is proposing to: A. Collect blood sample that will be used to extract DNA from buffy coat isolation and/or lymphoblastoid cell lines to establish a repository at Cedars-Sinai Medical Center. The DNA collected for this repository study will provide an ongoing source of ¿normal¿ specimens to facilitate functional, molecular and genetic studies into the etiology of alcoholism and disease conditions in which the hormones and glands interact with the nervous system . This research may lead to new diagnostic, treatment and preventative strategies for alcoholism and neuroendocrine diseases. B. We are also proposing to collect blood samples during the daytime and nighttime alcohol sensitivity sessions described in protocol Pro00017519. The blood samples collected for this repository study will provide a source of specimens for future neuroendocrine measures. C. In addition, data collected at baseline and during the daytime and nighttime alcohol sensitivity sessions in protocol Pro00017519 will be used for future analysis determined by our research findings and those published in the literature. This repository will be established for the purpose of learning more about genetic and environmental risk factors for alcoholism and neuroendocrine disease conditions. The current repository protocol will be established to collect, store and distribute specimens and/or data for future research. In the current protocol, the study team is proposing to: A. Collect blood samples that will be used to extract DNA from buffy coat isolation and/or lymphoblastoid cell lines to establish a repository at Cedars-Sinai Medical Center. The DNA collected for this repository study will provide an ongoing source of ¿normal¿ specimens to facilitate functional, molecular and genetic studies into the etiology of alcoholism and neuroendocrine disease conditions. This research may lead to new diagnostic, treatment and preventative strategies for alcoholism and neuroendocrine diseases. B. We are also proposing to collect blood samples during the daytime and nighttime alcohol sensitivity sessions described in protocol Pro00017519. The blood samples collected for this repository study will provide a source of specimens for future neuroendocrine measures. C. In addition, data collected at baseline and during the daytime and nighttime alcohol sensitivity sessions in protocol Pro00017519 will be used for future analysis determined by our research findings and those published in the literature. The specimen/tissue sample collected for this repository study will provide an ongoing source of specimens to facilitate functional, molecular and genetic studies into the etiology of alcoholism and neuroendocrine disease conditions. This research may lead to new diagnostic, treatment and preventative strategies for alcoholism and neuroendocrine diseases. In addition, data collected will allow for future analysis determined by our research findings and those published in the literature.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在研究申请Pro 00017519中，我们确认未来可能计划对本研究期间收集的数据进行分析。此外，当IRB审查该研究时，委员会强烈建议建立一个单独的IRB方案，为未来的研究创建一个存储库。有人指出，通过在加拿大原子能委员会为这项研究建立一个单独的处置库议定书，可以获得最大的效益。 根据IRB的建议，我们在当前申请中建议建立标本/组织和数据存储库。将建立当前的储存库方案，以收集、储存和分发标本/组织和/或数据，供未来研究使用。 在当前方案中，研究团队建议： A.采集血液样本，用于从血沉棕黄层分离和/或淋巴母细胞样细胞系中提取DNA，以在Cedars-Sinai Medical Center建立储存库。为该储存库研究收集的DNA将提供正常标本的持续来源，以促进对酒精中毒病因学和激素和腺体与神经系统相互作用的疾病状况的功能，分子和遗传研究。这项研究可能会为酒精中毒和神经内分泌疾病带来新的诊断、治疗和预防策略。 B。我们还建议在方案Pro 00017519中描述的日间和夜间酒精敏感性会议期间采集血样。本储存库研究采集的血液样本将为未来的神经内分泌测量提供标本来源。 C.此外，方案Pro 00017519中基线时以及日间和夜间酒精敏感性会议期间收集的数据将用于根据我们的研究结果和文献中发表的结果确定的未来分析。 建立这一资料库的目的是更多地了解酗酒和神经内分泌疾病的遗传和环境风险因素。 将建立当前的储存库协议，以收集、储存和分发标本和/或数据，供未来研究使用。 在当前方案中，研究团队建议： A.采集血液样本，用于从血沉棕黄层分离和/或淋巴母细胞系中提取DNA，以在Cedars-Sinai Medical Center建立储存库。为这项储存库研究收集的DNA将提供一个持续的正常标本来源，以促进对酒精中毒和神经内分泌疾病病因学的功能、分子和遗传研究。这项研究可能会为酒精中毒和神经内分泌疾病带来新的诊断、治疗和预防策略。 B。我们还建议在方案Pro 00017519中描述的日间和夜间酒精敏感性会议期间采集血样。本储存库研究采集的血液样本将为未来的神经内分泌测量提供标本来源。 C.此外，方案Pro 00017519中基线时以及日间和夜间酒精敏感性会议期间收集的数据将用于根据我们的研究结果和文献中发表的结果确定的未来分析。 为本储存库研究采集的标本/组织样本将提供持续的标本来源，以促进对酒精中毒和神经内分泌疾病的病因学进行功能、分子和遗传研究。这项研究可能会为酒精中毒和神经内分泌疾病带来新的诊断、治疗和预防策略。此外，收集的数据将允许根据我们的研究结果和文献中发表的结果进行未来分析。