STEM CELL BIOLOGY: NEW DIRECTIONS IN CLINICAL AND BASIC RESEARCH

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 描述（由申请人提供）：本 COBRE 有 6 个目标：1) 发展一个由在干细胞生物学、分子生物学和分化转录调控、肺生理学和生物学以及基础研究转化为临床治疗方面具有互补背景的成熟研究人员组成的强大指导小组，2) 通过提供核心实验室、行政支持和总体资源来加强基础设施支持，以提高我们教师的研究竞争力，3) 招募和留住受资助的初级和已建立的教师，以便继续建立RIH 作为主要的干细胞研究中心。 4) 招募代表性不足的少数族裔教师，5) 确定骨髓干细胞的真实表型及其组织命运。研究通过受损组织的微泡传递表型信息，并确定分化的转录控制机制，6) 将基本干细胞研究转化为慢性阻塞性肺病和难治性血液恶性肿瘤患者组织恢复或纠正的临床试验。经验丰富的科学家团队将指导 3 名有前途的初级研究人员，并准备指导不同研究领域的其他人。这项工作的主题是围绕一般干细胞生物学和调节干细胞表型的方法进行协调。这三个项目是 1) 肺损伤及其对骨髓细胞表型的影响，2) 定向干细胞造血和分化（过渡期）和 3) 酪氨酸磷酸酶 Shp2 在干细胞特性维护中的作用。这些科学项目得到行政、流式细胞术、分子支持核心的支持。概述了继续指导初级 P.l.s 的计划和评估 P.l.s 进展的具体方法，并包括专门指导 P.l.s 获得 RO1 资金的计划。机构承诺是强有力的。还概述了新初级教师的招聘和发展计划。此次COBRE的获奖将有效促进“移植”干细胞生物学中心的持续发展。这笔资助为扩大我们对干细胞生物学的理解和开发肺和骨髓疾病组织再生的独特新方法带来了真正的希望。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This COBRE has 6 objectives: 1) The development of a strong mentoring group of established investigators with complementary backgrounds in stem cell biology, molecular biology and transcriptional regulation of differentiation, pulmonary physiology and biology, and the translation of basic research to clinical therapy, 2)The enhancement of infrastructure support by providing Core laboratories, administrative support and total resources to increase the research competitiveness of our faculty, 3) Recruit and retain funded junior and established faculty so as to continue the establishment of RIH as a major stem cell research center. 4) Recruit underrepresented minority faculty, 5) Determine the true phenotype of marrow stem cells and its tissue fate. To study the transfer of phenotype information via microvesicles from injured tissue and to define mechanisms of transcriptional control of differentiation, 6) Translate basic stem cell studies into clinical trials on tissue restoration or correction in patients with chronic obstructive lung disease and refractory hematologic malignancies. An experienced group of scientists will mentor 3 promising junior investigators and are prepared to mentor others in different research areas. The work is thematically coordinated around stem cell biology in general and approaches to modulating the stem cell phenoptype. The three projects are 1) Injured Lung and its Influence on Marrow Cell Phenotype, 2) Directed Stem Cell Hematopoieis and Differentiation (in transition) and 3) Tyrosine Phosphatase Shp2 in Stem Cell Property Maintenance. These scientific projects are supported by the Administrative, Flow Cytometry, Molecular Support Cores. Plans are outlined for the continued mentoring of junior P.l.s and specific approaches for evaluating the progress of the P.l.s and a plan to specifically guide the P.l.s to RO1 funding is included. Institutional commitment is strong. Plans are also outlined for the recruitment and development of new junior faculty. The award of this COBRE would effectively facilitate the continued development of a "transplanted" Center for Stem Cell Biology. This grant holds real promise for expanding our understanding of stem cell biology and developing unique new approaches for tissue regeneration in lung and marrow diseases.