STEM CELL BIOLOGY: NEW DIRECTIONS IN CLINICAL AND BASIC RESEARCH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 描述(由申请者提供)：Cobre有6个目标：1)发展一支强大的导师团队，在干细胞生物学、分子生物学和分化转录调控、肺生理学和生物学的转录调控方面具有互补的背景，并将基础研究转化为临床治疗；2)通过提供核心实验室、行政支持和总资源来加强基础设施支持，以提高我们教员的研究竞争力；3)招聘和留住有资金的初级和常设教员，以继续将RIH建立为主要的干细胞研究中心。4)招募代表不足的少数族裔教师；5)决定骨髓干细胞的真实表型及其组织命运。研究损伤组织通过微囊传递表型信息并确定转录调控分化的机制，6)将基础干细胞研究转化为慢性阻塞性肺疾病和难治性血液系统恶性肿瘤患者的组织修复或矫正的临床试验。一个经验丰富的科学家小组将指导3名有前途的初级研究人员，并准备在不同的研究领域指导其他人。这项工作围绕干细胞生物学和调节干细胞表型的方法进行了主题协调。这三个项目是1)损伤肺及其对骨髓细胞表型的影响，2)定向干细胞造血和分化(过渡期)和3)酪氨酸磷酸酶Shp2在干细胞特性维持中的作用。这些科学项目得到了行政、流式细胞术、分子支持核心的支持。概述了继续指导初级公益活动的计划，评估公益活动进展的具体方法，以及具体指导初级活动人员获得RO1资金的计划。机构承诺很强。还概述了招聘和发展新的初级教员的计划。Cobre的获奖将有效地促进干细胞生物学“移植”中心的继续发展。这笔赠款确实有望扩大我们对干细胞生物学的理解，并为肺部和骨髓疾病的组织再生开发独特的新方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This COBRE has 6 objectives: 1) The development of a strong mentoring group of established investigators with complementary backgrounds in stem cell biology, molecular biology and transcriptional regulation of differentiation, pulmonary physiology and biology, and the translation of basic research to clinical therapy, 2)The enhancement of infrastructure support by providing Core laboratories, administrative support and total resources to increase the research competitiveness of our faculty, 3) Recruit and retain funded junior and established faculty so as to continue the establishment of RIH as a major stem cell research center. 4) Recruit underrepresented minority faculty, 5) Determine the true phenotype of marrow stem cells and its tissue fate. To study the transfer of phenotype information via microvesicles from injured tissue and to define mechanisms of transcriptional control of differentiation, 6) Translate basic stem cell studies into clinical trials on tissue restoration or correction in patients with chronic obstructive lung disease and refractory hematologic malignancies. An experienced group of scientists will mentor 3 promising junior investigators and are prepared to mentor others in different research areas. The work is thematically coordinated around stem cell biology in general and approaches to modulating the stem cell phenoptype. The three projects are 1) Injured Lung and its Influence on Marrow Cell Phenotype, 2) Directed Stem Cell Hematopoieis and Differentiation (in transition) and 3) Tyrosine Phosphatase Shp2 in Stem Cell Property Maintenance. These scientific projects are supported by the Administrative, Flow Cytometry, Molecular Support Cores. Plans are outlined for the continued mentoring of junior P.l.s and specific approaches for evaluating the progress of the P.l.s and a plan to specifically guide the P.l.s to RO1 funding is included. Institutional commitment is strong. Plans are also outlined for the recruitment and development of new junior faculty. The award of this COBRE would effectively facilitate the continued development of a "transplanted" Center for Stem Cell Biology. This grant holds real promise for expanding our understanding of stem cell biology and developing unique new approaches for tissue regeneration in lung and marrow diseases.