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Stem Cells and Aging

干细胞与衰老

基本信息

批准号：
10630387
负责人：
PETER J. QUESENBERRY
金额：
$ 124.07万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

项目摘要

Overall Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Stem Cells and Aging is to develop a multidisciplinary translational Center for Stem Cells and Aging Biology and Therapeutics, focusing on the underlying mechanisms and therapeutic potentials in the stem cell and aging fields. The two areas of endeavor overlap extensively, one holding the promise of tissue restoration in a wide variety of disorders while the other underlies diseases that impact everyone and leads to death. Since the start of the COBRE nine years ago 17 junior investigators have received either full projects or pilots, with 369 research articles and cumulative extramural funding of over $20,000,000 largely from NIH. Seven of these individuals are still funded while 13 have sustained or advanced in their academic fields, with three entering the Biotechnology field. Since their COBRE funding, 5 have received promotions at Brown University. The main objective of the Phase 3 COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent and self- sustaining academic center of excellence- the Center for Stem Cells and Aging Biology and Therapeutics in 5 years. To achieve this main objective four specific aims are proposed as follows. 1) To provide strong leadership, structure and support to enhance translational stem cell and aging research, by providing critical equipment and unique expertise in flow cytometry, viral construction and extracellular isolation and characterization. 2) To facilitate and develop the Flow Cytometry, Lentivirus Construct, and the Extracellular Vesicle Cores, by evaluating and focusing the performance of the Cores toward the goal of long-term independence, sustainability, and regional growth. 3) To guide the Pilot Project Program in translational stem cell and aging related research, toward extramural funding, with expert mentorship from successful local faculty through support of the Administrative Core. 4) Enhance translational research in the Rhode Island community by encouraging and enabling collaborations between clinicians and basic researchers at the junior and senior investigator levels. Our vision is by sustaining and transitioning the established high caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators and senior investigators, to develop insights into diseases and disorders of stem cells and aging, leading in turn to effective clinical therapeutic approaches.

全面的抽象的干细胞和衰老生物医学卓越研究中心 (COBRE) 的长期目标是建立干细胞、衰老生物学和治疗学多学科转化中心，重点关注 the underlying mechanisms and therapeutic potentials in the stem cell and aging fields.两个领域一项努力广泛重叠，一项有望在多种疾病中恢复组织，同时 the other underlies diseases that impact everyone and leads to death.自 COBRE 启动九年来 ago 17 junior investigators have received either full projects or pilots, with 369 research articles and cumulative extramural funding of over $20,000,000 largely from NIH. Seven of these individuals are still funded while 13 have sustained or advanced in their academic fields, with three entering the Biotechnology field.自从他们的在 COBRE 的资助下，5 人获得了布朗大学的晋升。 COBRE 第 3 阶段的主要目标是 to strengthen and transition the COBRE research infrastructure into a competitive, independent and self- sustaining academic center of excellence- the Center for Stem Cells and Aging Biology and Therapeutics in 5 年。 To achieve this main objective four specific aims are proposed as follows. 1）提供强有力的领导， structure and support to enhance translational stem cell and aging research, by providing critical equipment and unique expertise in flow cytometry, viral construction and extracellular isolation and characterization. 2) 至 facilitate and develop the Flow Cytometry, Lentivirus Construct, and the Extracellular Vesicle Cores, by 评估并集中核心的绩效以实现长期独立性、可持续性、和区域增长。 3) 指导转化干细胞和衰老相关研究试点项目，获得校外资助，并通过成功的当地教师的专家指导以及行政核心。 4) 通过鼓励和加强罗德岛社区的转化研究 enabling collaborations between clinicians and basic researchers at the junior and senior investigator levels.我们的愿景是通过维持和转变已建立的高水平研究基础设施，我们将实现临床医生与基础研究科学家、初级研究人员和高级研究人员并肩工作，深入了解干细胞的疾病和紊乱以及衰老，进而导致有效的临床治疗治疗方法。