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Stem Cells and Aging

干细胞与衰老

基本信息

批准号：
10630387
负责人：
PETER J. QUESENBERRY
金额：
$ 124.07万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

项目摘要

Overall Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Stem Cells and Aging is to develop a multidisciplinary translational Center for Stem Cells and Aging Biology and Therapeutics, focusing on the underlying mechanisms and therapeutic potentials in the stem cell and aging fields. The two areas of endeavor overlap extensively, one holding the promise of tissue restoration in a wide variety of disorders while the other underlies diseases that impact everyone and leads to death. Since the start of the COBRE nine years ago 17 junior investigators have received either full projects or pilots, with 369 research articles and cumulative extramural funding of over $20,000,000 largely from NIH. Seven of these individuals are still funded while 13 have sustained or advanced in their academic fields, with three entering the Biotechnology field. Since their COBRE funding, 5 have received promotions at Brown University. The main objective of the Phase 3 COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent and self- sustaining academic center of excellence- the Center for Stem Cells and Aging Biology and Therapeutics in 5 years. To achieve this main objective four specific aims are proposed as follows. 1) To provide strong leadership, structure and support to enhance translational stem cell and aging research, by providing critical equipment and unique expertise in flow cytometry, viral construction and extracellular isolation and characterization. 2) To facilitate and develop the Flow Cytometry, Lentivirus Construct, and the Extracellular Vesicle Cores, by evaluating and focusing the performance of the Cores toward the goal of long-term independence, sustainability, and regional growth. 3) To guide the Pilot Project Program in translational stem cell and aging related research, toward extramural funding, with expert mentorship from successful local faculty through support of the Administrative Core. 4) Enhance translational research in the Rhode Island community by encouraging and enabling collaborations between clinicians and basic researchers at the junior and senior investigator levels. Our vision is by sustaining and transitioning the established high caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators and senior investigators, to develop insights into diseases and disorders of stem cells and aging, leading in turn to effective clinical therapeutic approaches.

总括摘要干细胞和衰老生物医学研究卓越中心(COBRE)的长期目标是建立干细胞、衰老生物学和治疗学的多学科翻译中心，专注于干细胞和衰老领域的潜在机制和治疗潜力。这两个领域努力有广泛的重叠，一种在各种各样的疾病中保持组织修复的前景，同时另一种是影响每个人并导致死亡的疾病。从科布雷开始的九年 17名初级调查人员收到了完整的项目或试点项目，有369篇研究文章和累积超过2000万美元的外部资金，主要来自NIH。这些人中有7人仍有资金，而13人在自己的学术领域保持或进步，其中三人进入生物技术领域。因为他们的科布雷资助，5人已在布朗大学获得升职。第三阶段Cobre的主要目标是加强和转变科布雷研究基础设施，使其具有竞争力、独立性和自主性持续卓越的学术中心-干细胞与衰老生物学和治疗中心5 好几年了。为实现这一主要目标，现提出四个具体目标如下。1)提供强有力的领导，结构和支持，以加强翻译干细胞和衰老研究，通过提供关键设备和在流式细胞术、病毒构建以及细胞外分离和鉴定方面具有独特的专业知识。2)至通过以下方式促进和发展流式细胞术、慢病毒构建和细胞外小泡核心评估和注重核心的业绩，以实现长期独立、可持续、和区域增长。3)指导翻译干细胞和衰老相关研究的试点项目计划；在成功的当地教师的专家指导下，通过支持管理核心。4)加强罗德岛社区的翻译研究，鼓励和促进初级和高级研究人员级别的临床医生和基础研究人员之间的协作。我们的愿景是通过维持和过渡已建立的高水平研究基础设施，我们将实现临床医生与基础研究科学家、初级调查人员和高级调查人员并肩工作，以发展对干细胞疾病和紊乱以及衰老的洞察力，进而导致有效的临床治疗方法。