COBRE: U OF KANSAS MEDICAL CTR: CENTER JOINT PROJECTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们举行了多次会议，以决定我们可能会发展成计划项目的主题。因为代谢综合征是一个主要的公共健康问题，而NASH(非酒精性脂肪性肝炎)是这种综合征的一个组成部分，我们决定检查可能导致这种现象的因素。因此，我们设计了四个实验来研究小鼠的昼夜节律、不同的遗传背景(品系)、不同的饮食和年龄(年龄)。我们收集了其中三个实验的组织。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We had a number of meetings to decide topics that we might develop into program projects. Because the metabolic syndrome is a major public health problem, and NASH (non-alcoholic steahepatitis) is a component of this syndrome, we decided to examine factors that might contribute to this phenomenon. Therefore, we have designed four experiments to investigate the circadian rhythm, various genetic backgrounds (strains), various diets, and ages (old) of mice. We have collected the tissues of three of these experiments.