COBRE: U OF KANSAS MEDICAL CTR: CENTER JOINT PROJECTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们召开了多次会议，以决定我们可能发展成计划项目的主题。 由于代谢综合征是一个主要的公共卫生问题，NASH（非酒精性脂肪性肝炎）是这种综合征的一个组成部分，我们决定检查可能导致这种现象的因素。 因此，我们设计了四个实验来研究小鼠的昼夜节律、各种遗传背景（品系）、各种饮食和年龄（老年）。 我们收集了其中三个实验的组织。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We had a number of meetings to decide topics that we might develop into program projects. Because the metabolic syndrome is a major public health problem, and NASH (non-alcoholic steahepatitis) is a component of this syndrome, we decided to examine factors that might contribute to this phenomenon. Therefore, we have designed four experiments to investigate the circadian rhythm, various genetic backgrounds (strains), various diets, and ages (old) of mice. We have collected the tissues of three of these experiments.