LSU VETERINARY COBRE: PATHOGENESIS OF BORRELIA BURGDORFERI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 该项目研究莱姆病的致病机理，莱姆病是北美和欧洲最常见的媒介传播疾病。仅在美国，每年就有超过20，000人感染莱姆病。莱姆病是一种多系统疾病，可导致关节炎、神经系统异常、心脏炎和皮肤病变，如游走性红斑和慢性萎缩性肢端皮炎。高达10%的莱姆病患者可能会在治疗后出现莱姆病综合征，这是一种无法治愈的神秘疾病。作为一种生长缓慢的胞外细菌，在最佳体外条件下倍增时间约为8小时，B。伯氏螺旋体在鼠宿主中具有小于100个生物体的50%感染剂量（ID 50），并且尽管针对该病原体产生了强烈的免疫应答，但也可引起持续感染，使其本身成为人类和动物中最具侵袭性的微生物病原体之一。重点从以下三个方面阐述了B的发病机制。伯格多费里。 1.怎么样B。Burgdorferi逃避吞噬细胞的初始清除 2.怎么样B。burgdorferi逃避特定的体液反应 3.怎么样B。莱姆病引起的关节炎

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project studies the pathogenesis of Borrelia burgdorferi that causes Lyme disease, the most common vectorborne illness in North America and Europe. Over 20,000 people contract Lyme disease annually in the United States alone. Lyme disease is a multi-system disorder that can result in arthritis, neurological abnormalities, carditis and cutaneous lesions such as erythema migrans and acrodermatitis chronica atrophicans. Up to 10% Lyme disease patients may develop post-treatment Lyme syndrome, a mysterious illness that can not be cured. As a slow growing extracellular bacterium with a doubling time of approximately 8 hours in the best in vitro conditions, B. burgdorferi has a 50% infectious dose (ID50) of less than 100 organisms in the murine host, and can also cause persistent infection despite the development of vigorous immune responses against the pathogen, making itself one of the most invasive microbial pathogens in both humans and animals. The focus is on the following three aspects of the pathogenesis of B. burgdorferi. 1. How B. burgdorferi evades initial elimination by phagocytes 2. How B. burgdorferi evades specific humoral responses 3. How B. burgdorferi causes Lyme arthritis