LSU VETERINARY COBRE: PATHOGENESIS OF BORRELIA BURGDORFERI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目研究导致莱姆病的伯氏疏螺旋体的发病机制，莱姆病是北美和欧洲最常见的媒介传播疾病。仅在美国，每年就有超过2万人感染莱姆病。莱姆病是一种多系统疾病，可导致关节炎、神经异常、心脏炎和皮肤损害，如红斑迁徙和慢性萎缩性肢端皮炎。高达10%的莱姆病患者可能会患上治疗后的莱姆综合征，这是一种无法治愈的神秘疾病。伯氏杆菌是一种生长缓慢的胞外细菌，在最好的体外条件下，其倍增时间约为8小时，在小鼠宿主中的半数感染量(ID50)小于100个微生物，尽管对该病原体产生了强烈的免疫反应，但仍可引起持续感染，使其成为对人和动物最具侵袭性的微生物病原体之一。重点阐述了伯氏杆菌致病机理的三个方面。 1.伯氏杆菌如何逃避吞噬细胞的最初清除 2.B.burgdorferi如何逃避特定的体液反应 3.伯氏杆菌如何引起莱姆关节炎

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project studies the pathogenesis of Borrelia burgdorferi that causes Lyme disease, the most common vectorborne illness in North America and Europe. Over 20,000 people contract Lyme disease annually in the United States alone. Lyme disease is a multi-system disorder that can result in arthritis, neurological abnormalities, carditis and cutaneous lesions such as erythema migrans and acrodermatitis chronica atrophicans. Up to 10% Lyme disease patients may develop post-treatment Lyme syndrome, a mysterious illness that can not be cured. As a slow growing extracellular bacterium with a doubling time of approximately 8 hours in the best in vitro conditions, B. burgdorferi has a 50% infectious dose (ID50) of less than 100 organisms in the murine host, and can also cause persistent infection despite the development of vigorous immune responses against the pathogen, making itself one of the most invasive microbial pathogens in both humans and animals. The focus is on the following three aspects of the pathogenesis of B. burgdorferi. 1. How B. burgdorferi evades initial elimination by phagocytes 2. How B. burgdorferi evades specific humoral responses 3. How B. burgdorferi causes Lyme arthritis