COBRE Center for Evolutionary and Theoretical Immunology

COBRE 进化和理论免疫学中心

• 批准号: 7915458
• 负责人: ERIC SAMUEL LOKER
• 金额: $ 226.14万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915458
• 关键词: COBRE; Center; Evolutionary; Theoretical; Immunology

DESCRIPTION (provided by applicant): Building on the critical mass of expertise and infrastructure assembled during our first funding period, this proposal seeks five more years of support through NCRR's COBRE program to enable us to further strengthen and consolidate a self-sustaining and flourishing Center for Evolutionary and Theoretical Immunology (CETI). Once again, both junior and senior faculty scholars from the Biology and Computer Science Departments at the University of New Mexico and the Los Alamos National Labs will undertake research projects that seek to reveal basic design principles of immune systems, that model the interactions between pathogens and immune systems, and that explore the evolution of immune responses across animal phyla. Consequently, we will better understand how invertebrate vectors transmit infectious diseases, how pathogens defend themselves from immune attack and how the comparative study of immune systems can lead to exciting new conceptual frameworks and paradigms. We will also improve our mentoring program to develop independently-funded junior investigators, provide our members logistical support in grant preparation and management and at every opportunity strive to improve their long-term career prospects. We will hire additional CETI-related tenure track faculty and continue to partner with other NCRR programs and the UNM administration to support and improve CETI's core facilities in molecular biology, controlled environments and mass spectrometry/proteomics. We will also expand and improve the physical home of CETI by moving into new facilities that CETI has leveraged through productive partnerships with the UNM administration, and we will initiate a new seed grant program to increase the breadth and impact of CETI. We will develop multi-investigator proposals to mark CETI's graduation from NCRR funding and continue to seek new ways to promote integration and collaborations among our members and with the New Mexico research community. Lastly, CETI will increasingly serve as a catalyst to develop new training and biomedical research opportunities in our state and will use our critical mass to undertake initiatives and favor research enabling us to achieve world class recognition and prominence. PUBLIC HEALTH RELEVANCE (provided by applicant): Research conducted by investigators at the Center for Evolutionary and Theoretical Immunology will increase our understanding of the transmission of human parasitic diseases and may lead to the development of new therapeutics. In addition, models of viral diseases will be developed that will improve our ability to predict the spread of epidemics as well as evaluate effectiveness of different treatment regimes.

描述（由申请人提供）：基于在我们的第一个资金期间组装的专业知识和基础设施的重要质量，该提案通过NCRR的COBRE计划寻求五年的支持，以使我们能够进一步增强和巩固一个自我维持和繁荣的进化和理论免疫学（CETI）。再一次，来自新墨西哥大学生物学和计算机科学系的初级和高级教师学者和洛斯阿拉莫斯国家实验室将进行研究项目，旨在揭示免疫系统的基本设计原理，以模拟病原体与免疫系统之间的相互作用，并探索跨动物疫苗的免疫反应的进化。因此，我们将更好地理解无脊椎动物媒介如何传播传染病，病原体如何捍卫自己免受免疫攻击以及免疫系统的比较研究如何导致令人兴奋的新概念框架和范式。我们还将改善我们的指导计划，以开发由独立资助的初级调查人员，在赠款准备和管理方面为会员提供后勤支持，并努力提高其长期职业前景。我们将聘请其他与CETI相关的任期教师，并继续与其他NCRR计划和UNM管理计划合作，以支持和改善CETI在分子生物学，受控环境和质谱/蛋白质组学方面的核心设施。我们还将通过与UNM政府建立生产伙伴关系来利用CETI利用的新设施，扩大和改善CETI的物理住所，我们将启动一项新的种子赠款计划，以增加CETI的广度和影响。我们将制定多个投资者的建议，以纪念CETI从NCRR资助中毕业，并继续寻求新的方法来促进我们的会员之间以及与新墨西哥州研究社区之间的融合和合作。最后，CETI将越来越多地成为在我们州开发新的培训和生物医学研究机会的催化剂，并将利用我们的批判群众进行主动行动并有利于研究，使我们能够实现世界一流的认可和知名度。 公共卫生相关性（由申请人提供）：进化和理论免疫学中心的研究人员进行的研究将增加我们对人类寄生虫疾病传播的理解，并可能导致新的治疗学的发展。此外，还将开发病毒疾病模型，以提高我们预测流行病的传播以及评估不同治疗方案的有效性的能力。