SC COBRE: ANIMAL PATHOBIOLOGY CORE

SC COBRE：动物病理学核心

• 批准号: 8168044
• 负责人: Ashley J. Snider
• 金额: $ 18.15万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168044
• 关键词: Animal Experimentation; Animal Model; Animals; Area; Autopsy; Biomedical Research; Cardiovascular Diseases; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Data; Data Analyses; Databases; Disease; Ensure; Equipment; Evaluation; Faculty; Funding; Genes; Grant; Health; Inflammation; Inflammatory; Institution; Investigation; Malignant Neoplasms; Mentors; Monitor; Mus; Nerve Degeneration; Pathogenesis; Pathology; Rattus; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Source; System; Technical Expertise; Training; Transgenic Organisms; United States National Institutes of Health; animal breeding; animal resource; cost; in vivo; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of the Animal Pathobiology Core is to provide the SC COBRE in Lipidomics and Pathobiology investigators with the ability to utilize animal models in the execution of their proposed research projects as well as establish new animal models for the investigation of the mechanisms involved in the pathogenesis of disease. The Center will utilize two animal models, mice and rats, in the execution of the research projects. Although the use of animal models provides an invaluable source of reagents for investigating regulatory mechanisms in vivo, in a physiologically regulated system, the use of animals in biomedical research is costly with respect to equipment, animal resources and technical expertise. The Animal Core will serve as a resource for the execution and training in the use of all animal manipulations needed in the center. The Animal Core will minimize the cost of utilizing animal models in the Center research program by consolidating the equipment, expertise and animal resources. This will ensure an efficient use of animal research at minimal cost and reduce variables that could compromise data analysis between projects. The overall aims of the proposal are: Specific Aim 1: To ensure the efficient planning, purchase and utilization of experimental animals including transgenic and gene-altered mice, to maintain stocks of all animals and to breed animals for the COBRE investigators. In addition, to generate transgenic and gene-altered animals needed by the COBRE investigators to carry out the aims of the projects and to generate preliminary data for R01 submissions. Specific Aim 2: To provide the necessary facilities and faculty and staff expertise to support the research projects. The Core will provide resources, training and mentoring in animal models of neurodegeneration, cardiovascular disease, cancer and inflammation. Specific Aim 3: To provide expertise in mouse pathology with up-to-date proficiency in neurodegenerative, inflammatory, cardiovascular disease and cancer pathobiology. Both PI and co-PI have extensive expertise in the area of pathology to provide the necessary infrastructure. Specific Aim 4: To maintain a database that will include monitoring and tracking of all project animals. Animals will be uniquely identified with animal tagging chips and the Core will input all animal health and final pathological evaluations at necropsy into the database. These efforts will facilitate the research and provide the expertise to develop young faculty and establish research centers.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 动物病理生物学核心的总体目标是在脂质组学和病理生物学研究者中提供SC毛病，以便能够在执行其拟议的研究项目中利用动物模型，并为疾病病原体涉及的机制建立新的动物模型。该中心将在执行研究项目中利用两种动物模型，小鼠和大鼠。尽管动物模型的使用提供了用于研究体内调节机制的试剂的宝贵来源，但在生理调节的系统中，在生物医学研究中使用动物在设备，动物资源和技术专业知识方面的代价高昂。动物核心将作为使用中心所需的所有动物操作的执行和培训的资源。动物核心将通过巩固设备，专业和动物资源来最大程度地降低中心研究计划中使用动物模型的成本。这将确保有效利用动物研究以最低的成本利用，并减少可能损害项目之间数据分析的变量。该提案的总体目的是：具体目的1：确保包括转基因和基因改变小鼠在内的实验动物的有效计划，购买和利用，以维持所有动物的库存，并繁殖动物为毛cor研究者。此外，要生成鞋底研究人员所需的转基因和基因改变动物，以实现项目的目的并为R01提交生成初步数据。具体目标2：提供必要的设施以及教职员工和员工专业知识来支持研究项目。核心将在神经退行性，心血管疾病，癌症和炎症的动物模型中提供资源，培训和指导。特定目的3：提供小鼠病理学专业知识，具有最新的神经退行性，炎症，心血管疾病和癌症病理生物学的能力。 PI和CO-PI都在病理领域具有广泛的专业知识，以提供必要的基础设施。特定目标4：维护一个数据库，其中包括对所有项目动物的监视和跟踪。动物将被动物标记芯片唯一地识别，核心将在数据库中输入所有动物健康和最终病理评估。这些努力将促进研究，并为发展年轻教师和建立研究中心提供专业知识。