SC COBRE: ANIMAL PATHOBIOLOGY CORE

SC COBRE：动物病理学核心

• 批准号: 8360379
• 负责人: Ashley J. Snider
• 金额: $ 17.97万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-07-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360379
• 关键词: Animal Experimentation; Animal Model; Animals; Area; Autopsy; Biomedical Research; Cardiovascular Diseases; Centers of Research Excellence; Data; Data Analyses; Databases; Disease; Ensure; Equipment; Evaluation; Faculty; Funding; Genes; Grant; Health; Inflammation; Inflammatory; Investigation; Malignant Neoplasms; Mentors; Monitor; Mus; National Center for Research Resources; Nerve Degeneration; Pathogenesis; Pathology; Principal Investigator; Rattus; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Source; System; Technical Expertise; Training; Transgenic Organisms; United States National Institutes of Health; animal breeding; animal resource; cost; in vivo; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of the Animal Pathobiology Core is to provide the SC COBRE in Lipidomics and Pathobiology investigators with the ability to utilize animal models in the execution of their proposed research projects as well as establish new animal models for the investigation of the mechanisms involved in the pathogenesis of disease. The Center will utilize two animal models, mice and rats, in the execution of the research projects. Although the use of animal models provides an invaluable source of reagents for investigating regulatory mechanisms in vivo, in a physiologically regulated system, the use of animals in biomedical research is costly with respect to equipment, animal resources and technical expertise. The Animal Core will serve as a resource for the execution and training in the use of all animal manipulations needed in the center. The Animal Core will minimize the cost of utilizing animal models in the Center research program by consolidating the equipment, expertise and animal resources. This will ensure an efficient use of animal research at minimal cost and reduce variables that could compromise data analysis between projects. The overall aims of the proposal are: Specific Aim 1: To ensure the efficient planning, purchase and utilization of experimental animals including transgenic and gene-altered mice, to maintain stocks of all animals and to breed animals for the COBRE investigators. In addition, to generate transgenic and gene-altered animals needed by the COBRE investigators to carry out the aims of the projects and to generate preliminary data for R01 submissions. Specific Aim 2: To provide the necessary facilities and faculty and staff expertise to support the research projects. The Core will provide resources, training and mentoring in animal models of neurodegeneration, cardiovascular disease, cancer and inflammation. Specific Aim 3: To provide expertise in mouse pathology with up-to-date proficiency in neurodegenerative, inflammatory, cardiovascular disease and cancer pathobiology. Both PI and co-PI have extensive expertise in the area of pathology to provide the necessary infrastructure. Specific Aim 4: To maintain a database that will include monitoring and tracking of all project animals. Animals will be uniquely identified with animal tagging chips and the Core will input all animal health and final pathological evaluations at necropsy into the database. These efforts will facilitate the research and provide the expertise to develop young faculty and establish research centers.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 动物病理生物学核心的总体目标是为脂质组学和病理生物学研究人员提供利用动物模型执行其拟议研究项目的能力，以及建立新的动物模型以研究疾病发病机制。该中心将利用两种动物模型，小鼠和大鼠，在执行研究项目。虽然动物模型的使用为研究体内调节机制提供了宝贵的试剂来源，但在生理调节系统中，在生物医学研究中使用动物在设备、动物资源和技术专长方面是昂贵的。动物核心将作为中心所需的所有动物操作的执行和培训资源。动物中心将通过整合设备、专业知识和动物资源，最大限度地降低中心研究计划中使用动物模型的成本。这将确保以最低的成本有效利用动物研究，并减少可能影响项目之间数据分析的变量。具体目标1：确保有效规划、购买和利用实验动物，包括转基因和基因改造小鼠，维持所有动物的库存，并为COBRE研究人员繁殖动物。此外，还将产生COBRE研究人员所需的转基因和基因改变动物，以实现项目的目标，并为R 01提交文件提供初步数据。具体目标2：提供必要的设施和教师和工作人员的专业知识，以支持研究项目。核心将提供资源，培训和指导神经退行性疾病，心血管疾病，癌症和炎症的动物模型。具体目标3：提供小鼠病理学方面的专业知识，并掌握神经退行性疾病、炎症、心血管疾病和癌症病理生物学方面的最新知识。PI和co-PI在病理学领域拥有丰富的专业知识，可提供必要的基础设施。具体目标4：维护一个数据库，其中包括对所有项目动物的监测和跟踪。将使用动物标签芯片对动物进行唯一识别，核心人员将在尸检时将所有动物健康和最终病理学评价输入数据库。这些努力将促进研究，并提供专业知识，以发展年轻的教师和建立研究中心。