REGULATION OF K+ CURRENTS IN NEURONAL EXCITABILITY

K 电流对神经元兴奋性的调节

• 批准号: 8167396
• 负责人: Laura Schrader
• 金额: $ 15.97万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167396
• 关键词: Binding; Computer Retrieval of Information on Scientific Projects Database; DNA Binding; EF Hand Motifs; Funding; Genetic Transcription; Grant; Institution; Neurons; Nuclear Translocation; Perforant Pathway; Phosphorylation; Phosphotransferases; Property; Regulation; Research; Research Personnel; Resources; Source; Synapses; Synaptic plasticity; United States National Institutes of Health; granule cell; neuronal excitability

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims are as follows: 1) K3/DR/C regulates dentate granule cell synaptic plasticity at the perforant path/dentate granule cell synapse. 2) Determine whether release of Ca2+ from intracellular stores is sufficient and Ca2+ binding to EF hands is necessary to cause nuclear translocation of K3/DR/C in neurons. 3) Determine whether direct phosphorylation of K3/DR/C by kinases modulates DNA binding properties and gene transcription.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 其目标如下： 第一章 K3/DR/C在穿通通路/齿状颗粒细胞突触处调节齿状颗粒细胞突触可塑性。 （二） 确定细胞内储存的Ca 2+释放是否足够，以及Ca 2+与EF手的结合是否是引起神经元中K3/DR/C核转位所必需的。 第三章 确定激酶对K3/DR/C的直接磷酸化是否调节DNA结合特性和基因转录。