Hormones & Behavior Core

荷尔蒙与行为核心(核心C)摘要 母计划项目的目标是调查简化的可能的机械决定因素 在病理条件下，雌激素对女性认知老化的疗效，如心血管疾病和 肥胖。为了评估雌二醇从有益于认知功能转变为 可能会出现中性甚至有害的情况，本提案中的项目将调查衰老的认知功能 雌性啮齿动物在不同心脏代谢健康和疾病条件下，无论有没有雌激素 治疗。核心C(荷尔蒙和行为核心)将促进这项工作，并有助于 项目总体规划通过两个具体目标的完成。目标1将建立一种啮齿动物模型 更年期和激素治疗在所有四个项目中都是统一的，目标2将增强僵硬和 通过标准化跨研究使用的行为测试和评估来实现重复性。内部核心服务 与独立调查相比，方案项目具有优势，因为它们允许进行仔细的规划 以及协调所有项目之间的研究设计、疾病模型以及数据收集和分析 否则，对于在不同机构获得不同拨款的研究人员来说，将被证明是困难的。这种协调 将通过消除生物年龄中特定于项目的变异性来显著影响研究范围， 时间表、饮食成分和疾病模型，从而允许在研究之间进行推断，这些研究可能 否则就永远不会成功。

Hormones & Behavior Core (Core C) Summary The goals of the parent Program Project are to investigate possible mechanistic determinants of reduced estradiol efficacy on female cognitive aging under pathological conditions, such as cardiovascular disease and obesity. In order to assess mechanisms by which estradiol’s switch from beneficial for cognitive function to neutral or even detrimental may occur, the projects in this proposal will investigate cognitive function in aging female rodents under varying conditions of cardiometabolic health and disease both with and without estradiol treatment. Core C (Hormones & Behavior Core) will facilitate this work and contribute to the success of the overall Program Project through the completion of two specific aims. Aim 1 will establish a rodent model of menopause and hormone therapy that is uniform across all four projects, and Aim 2 will enhance rigor and reproducibility by standardizing the behavioral tests and assessments used across studies. Core services within a program project are advantageous compared to independent investigations as they allow for careful planning and coordination of research design, disease models, and data collection and analysis among all projects which would otherwise prove difficult for researchers with separate grants at separate institutions. This coordination will significantly impact the scope of the research by eliminating project-specific variability in biological age, timelines, dietary components, and disease models and thus permitting inferences between studies that could otherwise never be made.