Hormones & Behavior Core

激素与行为核心（核心C）摘要 父母计划项目的目标是调查可能的机械决定因素减少 雌二醇在病理条件下对女性认知老化的功效，如心血管疾病和 肥胖为了评估雌二醇从有益于认知功能转变为 中性甚至有害的可能发生，本提案中的项目将调查衰老中的认知功能 雌性啮齿类动物在不同的心脏代谢健康和疾病条件下（含和不含雌二醇） 治疗核心C（激素和行为核心）将促进这项工作，并有助于成功的 通过完成两个具体目标，实现总体方案项目。目的1建立一种啮齿动物模型， 更年期和激素治疗是统一的所有四个项目，目标2将提高严谨性， 通过标准化跨研究使用的行为测试和评估来提高可重复性。内部核心服务 与独立调查相比，计划项目具有优势，因为它们允许仔细规划 协调所有项目的研究设计、疾病模型以及数据收集和分析， 否则，对于在不同机构获得不同赠款的研究人员来说，这将是困难的。这种协调 将通过消除生物年龄的项目特异性变异性， 时间表，饮食成分和疾病模型，从而允许研究之间的推断， 否则永远不会被制造。

Hormones & Behavior Core (Core C) Summary The goals of the parent Program Project are to investigate possible mechanistic determinants of reduced estradiol efficacy on female cognitive aging under pathological conditions, such as cardiovascular disease and obesity. In order to assess mechanisms by which estradiol’s switch from beneficial for cognitive function to neutral or even detrimental may occur, the projects in this proposal will investigate cognitive function in aging female rodents under varying conditions of cardiometabolic health and disease both with and without estradiol treatment. Core C (Hormones & Behavior Core) will facilitate this work and contribute to the success of the overall Program Project through the completion of two specific aims. Aim 1 will establish a rodent model of menopause and hormone therapy that is uniform across all four projects, and Aim 2 will enhance rigor and reproducibility by standardizing the behavioral tests and assessments used across studies. Core services within a program project are advantageous compared to independent investigations as they allow for careful planning and coordination of research design, disease models, and data collection and analysis among all projects which would otherwise prove difficult for researchers with separate grants at separate institutions. This coordination will significantly impact the scope of the research by eliminating project-specific variability in biological age, timelines, dietary components, and disease models and thus permitting inferences between studies that could otherwise never be made.