REGULATION OF K+ CURRENTS IN NEURONAL EXCITABILITY

K 电流对神经元兴奋性的调节

• 批准号: 8359608
• 负责人: Laura Schrader
• 金额: $ 28.67万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359608
• 关键词: Binding; DNA Binding; EF Hand Motifs; Funding; Genetic Transcription; Grant; Louisiana; Mentors; National Center for Research Resources; Neurons; Neurosciences; Nuclear Translocation; Perforant Pathway; Phosphorylation; Phosphotransferases; Principal Investigator; Property; Regulation; Research; Research Infrastructure; Resources; Source; Synapses; Synaptic plasticity; United States National Institutes of Health; cost; granule cell; neuronal excitability; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The aims are as follows: 1) K3/DR/C regulates dentate granule cell synaptic plasticity at the perforant path/dentate granule cell synapse. 2) Determine whether release of Ca2+ from intracellular stores is sufficient and Ca2+ binding to EF hands is necessary to cause nuclear translocation of K3/DR/C in neurons. 3) Determine whether direct phosphorylation of K3/DR/C by kinases modulates DNA binding properties and gene transcription.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 其目标如下： 第一章 K3/DR/C在穿通通路/齿状颗粒细胞突触处调节齿状颗粒细胞突触可塑性。 （二） 确定细胞内储存的Ca 2+释放是否足够，以及Ca 2+与EF手的结合是否是引起神经元中K3/DR/C核转位所必需的。 第三章 确定激酶对K3/DR/C的直接磷酸化是否调节DNA结合特性和基因转录。