Mechanisms of cardiovascular remodeling

描述（由申请人提供）：本提案要求继续资助我们的生物医学研究卓越中心（COBRE）的“心血管重塑机制”。"最初的COBRE赠款使我们在桑福德医学院（SSOM，前身为南达科他州大学医学院）的心血管研究所（CRI）能够在心力衰竭领域建立全国卓越的研究声誉。COBRE资助促进了有前途的初级基础研究人员的职业发展，并促进了临床科学家的研究培训。资金使我们能够提高研究效率，建立优秀的核心设施，并招募优秀的新的初级和高级教师。这些发展导致了大量的出版物，其中许多在著名的医学期刊上发表，并使我们在苏福尔斯的临床校园建立了优秀的新研讨会和期刊俱乐部计划。这一非常成功的COBRE也成为当地（我们的合作医院承诺新的2000万美元研究投资，在苏福尔斯再开发4个研究机构）和州一级（州2010计划和在SSOM建立MD-博士项目）研究投资和扩展的主要催化剂。在我们的竞争性续期申请中，我们要求继续支持原始COBRE建立的基础设施，并为5名有前途的研究人员（4名初级和1名中级）提供项目资金。Tim O'Connell博士的项目1将研究α肾上腺素能受体在心肌梗死中的作用。Stephen Armstrong博士的项目2将研究扩张型心肌病和肌营养不良症中整合素信号传导的分子机制。梁强荣博士的项目3将研究抗癌药物阿霉素心脏毒性的分子机制。Erin Harmon的项目4将研究强直性肌营养不良激酶在肌细胞发育中的作用。项目5由大卫王将探讨甲状腺激素诱导成人心脏血管生成的分子机制。项目依赖于COBRE提供的管理、生理学、细胞培养、分子生物学和成像核心。 相关性--在COBRE资助下进行的工作涉及对与心脏发育、生长和疾病相关的心血管重塑的细胞和分子机制的研究。COBRE还促成了一个高度集中和富有成效的科学家小组的建立，他们在一个历史上在研究生产力方面排名垫底的州建立了心血管研究卓越的国家声誉。

DESCRIPTION (provided by applicant): This proposal requests continued funding for our Center of Biomedical Research Excellence (COBRE) on 'Mechanisms of Cardiovascular Remodeling." The original COBRE grant enabled our fledgling Cardiovascular Research Institute (CRI) at the Sanford School of Medicine (SSOM, formerly University of South Dakota School of Medicine) to develop a national reputation for research excellence in the area of heart failure. COBRE funding facilitated the career development of promising junior basic researchers and promoted research training for clinician scientists. Funding enabled us to improve research efficiency with the establishment of excellent core facilities and to recruit outstanding new junior and senior level faculty members. These developments resulted in a significant number of publications with many in prestigious medical journals and enabled the establishment of excellent new seminar and journal club programs on our clinical campus in Sioux Falls. This highly successful COBRE also served as a major catalyst for research investment and expansion at the local (new $20M research investment pledge by our partner hospital, development of 4 more research institutes in Sioux Falls) and State level (State 2010 Program and establishment of MD-PhD program at SSOM). In our competing renewal application, we are requesting continued support of the infrastructure established by the original COBRE and project funding for 5 promising investigators (4 junior and one mid level). Project 1 by Dr. Tim O'Connell will investigate the role of alpha adrenergic receptors in myocardial infarction. Project 2 by Dr. Stephen Armstrong will investigate molecular mechanisms of integrin signaling in dilated cardiomyopathy and muscular dystrophy. Project 3 by Dr. Qiangrong Liang will investigate the molecular mechanism of cardiac toxicity from the anti-cancer drug Doxorubicin. Project 4 by Erin Harmon will investigate the role of a myotonic dystrophy kinase in myocyte development. Project 5 by David Wang will investigate the molecular mechanisms of thyroid hormone induced angiogenesis in adult heart. Projects are dependent on the Administrative, Physiology, Cell Culture, Molecular Biology, and Imaging Cores provided by the COBRE. Relevance-Work being conducted in this COBRE grant involves investigations into the cellular and molecular mechanisms of cardiovascular remodeling associated with heart development, growth, and disease. The COBRE has also enabled the establishment of a highly focused and productive group of scientists who have established a national reputation for excellence in cardiovascular research in a State that has historically ranked near the bottom in research productivity.