BIOLOGICAL VARIABILITY IN THE OMEGA-3 INDEX

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Omega-3脂肪酸是鱼油中发现的重要营养素，最近已被证明可以降低心脏病发作和可能的神经精神疾病的风险。 Omega-3指数是这些疾病的一个潜在的新风险因素。 它是在人体血液中测量的，是红细胞膜中携带的ω-3脂肪酸量的简写术语。 关于影响omega-3指数的因素还有很多东西有待了解。 一个不知道的因素是这种血液标记物在正常饮食的正常人中有多大变化;这被称为“生物变异”。 虽然该检测的分析变异性已被定义，但其生物学变异性尚未定义，但在这种新的血液检测方法可用于临床之前，需要进行生物学变异性定义。 本研究将招募20名健康受试者，每周抽取血液，持续6周。 红细胞和血浆都将被分离出来，并测量每种细胞中的omega-3脂肪酸水平。 然后将使用统计检验来确定这两种组织的生物学变异。 研究结果将发表在一份医学杂志上。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Omega-3 fatty acids are important nutrients found in fish oils that have recently been shown to reduce risk for heart attacks and possibly neuropsychiatric diseases. The Omega-3 Index is a potential, new risk factor for these diseases. It is measured in human blood, and is a shorthand term for the amount of omega-3 fatty acids carried in red blood cell membranes. Much remains to be learned about the factors that influence the omega-3 index. One factor that is not known is how much this blood marker varies in normal people eating normal diets; this is called "biological variation". While the analytical variability of this test has been defined, its biological variation has not, but it needs to be before this new blood test can be used clinically. This study will involve recruiting 20 healthy subjects and drawing blood from them every week for 6 weeks. Both the red blood cells and the plasma will be isolated, and the omega-3 fatty acid levels measured in each. Statistical tests will then be used to define the biological variation for both of these tissues. The results will be published in a medical journal.