CENTER FOR VISUAL AND COGNITIVE NEUROSCIENCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 描述(由申请人提供)：我们建议在南洋理工大学续签我们的COBRE。我们的研究重点是视觉和认知神经科学。我们描述了由有前途的初级和高级研究人员指导的四个主题相关的主要项目，这些项目考察了视觉感知、视觉注意、视觉认知和行动的神经机制和功能意义。我们的具体目标是： 具体目标1：为Cobre项目主管开发成功的、独立的、自给自足的研究项目，以使未来能够成功地获得R01资金。这一目标将通过以下方式实现：争取COBRE对主题明确的研究项目的支持，建立一个由PI/PD、两人组成的内部咨询委员会、三人组成的外部咨询委员会以及五名项目导师组成的行政核心。 具体目标2：通过维护多用户核心实验室设施来加强NDSU的研究基础设施。科布雷的项目利用最先进的脑电神经成像来测量神经系统的结构和功能与其管理的行为之间的关系。我们将继续加强研究基础设施，支持高密度脑电核心实验室，配备一名全职脑电实验室技术员和两名全职计算机程序员。 具体目标#3：通过招聘一名在翻译神经科学方面具有研究专长的教员来扩大南大在视觉和认知神经科学方面的研究能力。我们建议在Cobre项目的第一年招聘一名视觉或认知神经学家。这一新招聘将增加我们关键的研究人才数量，使该中心在Cobre支持的最初几年后继续保持下去。这名新招聘的教员将有资格通过试点项目机制获得CVCN的支持。 具体目标4：在南洋理工大学建立一个国家认可的视觉和认知神经科学中心。具体目标1-3的实现将在南洋理工大学创建一个卓越的研究中心，确保吸引更多高质量的教员、博士后研究员和致力于视觉和认知神经科学前沿研究的研究生。南洋理工大学视觉和认知神经科学中心将在机构培训补助金(T32)、研究项目补助金(ROI)和基础设施发展补助金(R24)方面具有竞争力，这将使该中心在最初几年的支持之后继续保持下去。 与公共卫生相关(由申请者提供)：感知、认知、情绪、注意力和执行功能障碍是导致虚弱和代价高昂的疾病综合征(ADHD、ARMD、失认症、弱视、自闭症、抑郁症、痴呆症、阅读困难、偏执症、多发性硬化症、帕金森氏病、创伤后应激障碍和精神分裂症)的特征。同样重要的是，这种障碍在正常年龄相关的感觉和认知能力下降中普遍存在。科布雷致力于发现阐明并有可能改善这些状况的知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): We propose renewal of our COBRE at NDSU. Our research focus is Visual and Cognitive Neuroscience. We describe four thematically interrelated primary projects directed by promising junior and senior investigators, which examine the neural mechanisms and functional significance of visual perception, visual attention, visual cognition and action. Our Specific Aims are: SPECIFIC AIM #1: To develop successful, independent, self-sustaining research projects for COBRE Project Directors to enable future success in obtaining R01 funding. This aim will be accomplished by obtaining COBRE support for thematically articulated research projects and by establishing an Administrative Core consisting of the PI/PD, a two-member Internal Advisory Committee, a three-member External Advisory Committee, as well as a group of five Project Mentors. SPECIFIC AIM #2: To enhance research infrastructure at NDSU through maintenance of multiuser Core laboratory facilities. The projects of the COBRE utilize state-of-the-art EEG neuroimaging to measure relationships between the structure and function of the nervous system and the behavior it governs. We will continue to enhance research infrastructure by supporting the Core laboratory for High-Density EEG, staffed by a full-time EEG laboratory technician and two full-time computer programmers. SPECIFIC AIM #3: To expand NDSU's research capability in visual and cognitive neuroscience by recruiting an additional faculty member with research expertise in translational neuroscience. We propose to recruit a visual or cognitive neuroscientist during the first year of the COBRE project. This new recruit will augment our critical mass of research talent that will sustain the Center beyond the initial years of COBRE support. This newly recruited faculty member will be eligible for CVCN support through a Pilot Project mechanism. SPECIFIC AIM #4: To establish a nationally recognized Center for Visual and Cognitive Neuroscience at NDSU. The realization of Specific Aims 1-3 will create a center of research excellence at NDSU which is guaranteed to attract additional quality faculty, postdoctoral fellows and graduate students committed to cutting-edge research in visual and cognitive neuroscience. The NDSU Center for Visual and Cognitive Neuroscience will be competitive for Institutional Training Grants (T32), Research Project Grants (ROI), and Infrastructure Development Grants (R24) which will sustain the Center beyond the initial years of support. PUBLIC HEALTH RELEVANCE (provided by applicant): Disordered perception, cognition, emotion, attention and executive function are hallmarks of debilitating and costly disease syndromes (ADHD, ARMD, agnosia, amblyopia, autism, depression, dementia, dyslexia, hemineglect, multiple sclerosis, Parkinson's disease, PTSD, and schizophrenia). Equally significant is the prevalence of such disorders in normal age-related sensory and cognitive decline. This COBRE is dedicated to the discovery of knowledge that illuminates and potentially ameliorates these conditions.