Administrative Core

行政核心

• 批准号: 9983089
• 负责人: MARK E. McCourt
• 金额: $ 20.39万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9983089
• 关键词: Address; Advisory Committees; Amblyopia; American; Applications Grants; Area; Attention; Automobile Driving; Basic Science; Behavioral; Biological Markers; Biomedical Research; Centers of Research Excellence; Clinical Treatment; Cognition; Collection; Communication; Computer software; Core Facility; Data; Decision Making; Dementia; Development; Disease; Dyslexia; Early Diagnosis; Early Intervention; Education and Outreach; Electroencephalography; Electrophysiology (science); Ensure; Esthesia; Evaluation; Faculty; FarGo; Fee-for-Service Plans; Feedback; Fees; Foundations; Funding; Funding Agency; Future; Goals; Health; Human; Instruction; Intervention; Intervention Studies; Knowledge; Leadership; Maintenance; Mentors; Mentorship; Mission; Names; Neurosciences; North Dakota; Parkinson Disease; Participant; Perception; Perceptual Disorders; Performance; Phase; Pilot Projects; Procedures; Process; Publishing; Quality of life; Recovery; Research; Research Activity; Research Infrastructure; Research Personnel; Research Proposals; Resources; Schizophrenia; Services; South Dakota; Structure; Students; System; Talents; Technical Expertise; Time; Training Activity; Translational Research; Traumatic Brain Injury; Visit; authority; autism spectrum disorder; base; career development; cognitive neuroscience; cost; density; effective therapy; effectiveness evaluation; experience; infrastructure development; innovation; mild cognitive impairment; neuromechanism; normal aging; novel; operation; organizational structure; outreach; programs; recruit; relating to nervous system; research and development; response; success; symposium; tenure track; visual neuroscience; waiver; webinar

Basic and translational research into the neural bases of human sensation, perception, attention, and cognition is necessary to lay the foundation for clinical treatments and interventions. Remarkable progress has been made in the discovery of novel behavioral and electrophysiological biomarkers for disorders of perception, attention, cognition, and action. These include schizophrenia, Parkinson's, autism, dementia, mild cognitive impairment, traumatic brain injury, dyslexia, and amblyopia, to name but a few. These, along with normal aging, negatively impact the health and quality of life of a large number of Americans. Discovering biomarkers for such disorders allows early diagnosis and intervention, and translational research may result in the development of novel and effective treatments. Progress in the field as a whole is reflected in the research accomplishments of CVCN researchers in Phases I and II. In Phase III we will continue to contribute to novel discovery in visual and cognitive neuroscience by supporting creative research activity and world-class Core facilities that will potentiate further discovery. The Administrative Core provides the organizational structure to extend into Phase III the research and infrastructure development goals realized in Phases I and II. The Administrative Core will promote the continued success of research addressing the neural mechanisms of human sensation, perception, and cognition, and action, in both normal and disordered states, through: 1) the sustained efficient operation of 3 Scientific/Technical Cores (Technical Services Core; Driving Simulator Core; High-Density EEG/Neurostimulation Core) which provide mission-critical research resources to CVCN faculty and students, and which benefit the scientific activities of a broad array of current and future users on the NDSU campus and beyond; 2) continued support for a successful competitive Pilot Project Program, initiated in Phases I and II, which provides short-term support as well as scientific mentoring and career development services to applicants with promising research proposals; and 3) the development of, and active participation in, two outreach mechanisms (the Inter-COBRE Council and the Scientific Exchange Network) which will serve as conduits for the exchange of scientific and technical expertise and the dissemination of knowledge, research findings, ideas, and best practices, between COBREs with cognate research themes within the state, the region, and the nation. A formal evaluation process involving internal review and external oversight will be implemented to ensure that the various components of the CVCN are well integrated and operate effectively. A plan to ensure the sustained availability of the Scientific/Technical Cores beyond the Phase III funding period is described which combines efficient Core management, a fee-for-service cost recovery mechanism, and the commitment of permanent institutional resources.

人类感觉、知觉、注意和认知的神经基础的基础和转化研究 为临床治疗和干预奠定基础是必要的。了显著进展 在发现新的感知障碍的行为和电生理生物标志物方面取得了进展， 注意力、认知和行动。这些包括精神分裂症，帕金森氏症，自闭症，痴呆症，轻度认知障碍， 损伤、创伤性脑损伤、阅读障碍和弱视，仅举几例。这些，沿着与正常 老龄化对大量美国人的健康和生活质量产生了负面影响。发现生物标志物 对于这些疾病可以早期诊断和干预，转化研究可能会导致 开发新的有效治疗方法。整个领域的进展反映在研究中， CVCN研究人员在第一阶段和第二阶段的成就。在第三阶段，我们将继续为新的 通过支持创造性的研究活动和世界级的核心， 这些设施将有助于进一步的发现。行政核心提供组织结构， 将第一阶段和第二阶段实现的研究和基础设施发展目标扩展到第三阶段。的 行政核心将促进研究的持续成功，解决神经机制， 人的感觉，知觉，认知和行动，在正常和混乱的状态，通过：1） 3个科学/技术核心（技术服务核心;驾驶模拟器核心; 高密度EEG/神经刺激核心），为CVCN教师提供关键任务研究资源 这有利于目前和未来的广泛用户的科学活动， NDSU校园内外; 2）继续支持成功的竞争性试点项目计划，启动 在第一和第二阶段，提供短期支持以及科学指导和职业发展 为有前途的研究建议的申请人提供服务;以及3）发展和积极参与 在这方面，两个外联机制（COBRE理事会和科学交流网络）将服务于 作为交流科学技术专门知识和传播知识的渠道， 研究结果，想法和最佳实践，COBREs与国家内的同源研究主题之间， 地区和国家。包括内部审查和外部监督的正式评价程序将 我们已实施一套新系统，以确保CVCN的各个组成部分能妥善整合，并有效运作。一 确保在第三阶段供资期之后持续提供科学/技术核心的计划 它结合了高效的核心管理、按服务收费的成本回收机制以及 永久性机构资源的承诺。