Immonology Core

免疫学核心

• 批准号: 7929993
• 负责人: DOROTHY E. LEWIS
• 金额: $ 16.13万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-04 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7929993
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Area; Arts; Back; Biological Assay; Biological Markers; Cell Separation; Charge; Clinical Immunology; Cytometry; Data Analyses; Detection; Development; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fostering; Funding; Future; Goals; HIV Infections; Immune; Immune system; Immunologics; Immunology; Immunology procedure; Interdisciplinary Study; International; Laboratories; Measures; Medicine; Methods; Pathogenesis; Patients; Prevention; Research; Research Personnel; Research Support; Running; Services; System; Texas; Training; United States; catalyst; college; cost; cost effective; design; enzyme linked immunospot assay; experience; instrumentation; medical schools; member; success

The Baylor-UTHouston CFAR Immunology Core is designed to provide state-of-the-art flow cytometric capabilities, expertise for non-flow cytometry immunological assays, and technical training desired by members of the CFAR. A major goal Is to support research of high-priority CFAR initiatives that foster interdisciplinary research in areas of opportunity. The Core is organized into two separate but complementary laboratories, the Cytometry Laboratory (located at Baylor College of Medicine) and the Clinical Immunology Laboratory (located at UTHouston Medical School). Routine flow cytometry and cell sorting is conducted at reduced cost to CFAR members at the Cytometry Laboratory. The Clinical Immunology Laboratory provides other immunology services, including development and characterization of new assays such as ELISA and ELISPOT assays to measure biomarkers. The highly successful Immunology Core is directed by Dr. Dorothy E. Lewis, who has over 30 years of flow and immunologic experience and an outstanding track-record of bringing together interdisciplinary investigators. The CFAR Cytometry Laboratory at Baylor is managed by Joel Sederstrom, and the CFAR Clinical Immunology Laboratory at UTHouston by Jacob Couturier. The Core is supervised by an Oversight Committee. Future opportunity areas to be pursued by the Core include development of BSL2+ cell sorting capability, development of immune assays, and provision of advanced training in immunological methods. The Core Director has responsibility for day-to-day running of the Core laboratories; priorities for usage are prescribed in a standardized manner; a charge-back system is implemented where appropriate. This Core has been highly utilized and appreciated in our previous funding periods and it is anticipated that investigators at Baylor and UTHouston will benefit from its expanded services. Its support is essential for the continued success of the Baylor-UTHouston CFAR.

贝勒-休斯顿CFAR免疫学中心旨在提供最先进的流式细胞术功能，非流式细胞术免疫分析的专业知识，以及CFAR成员所需的技术培训。一个主要目标是支持高优先级CFAR计划的研究，以促进机会领域的跨学科研究。核心实验室分为两个独立但互补的实验室，细胞计数实验室（位于贝勒医学院）和临床免疫学实验室（位于乌斯顿医学院）。常规流式细胞术和细胞分选在CFAR成员的细胞计数实验室以较低的成本进行。临床免疫学实验室提供其他免疫学服务，包括开发和表征新的测定方法，如ELISA和ELISPOT测定生物标志物。非常成功的免疫学核心由Dorothy E. Lewis博士指导，他拥有超过30年的流动和免疫学经验，以及将跨学科研究人员聚集在一起的杰出记录。贝勒大学的CFAR细胞计数实验室由Joel Sederstrom管理，休斯敦大学的CFAR临床免疫学实验室由Jacob Couturier管理。核心由一个监督委员会监督。该中心未来的发展方向包括BSL2+细胞分选能力的开发、免疫检测的开发以及提供免疫学方法的高级培训。核心主任负责核心实验室的日常运作；以标准化方式规定使用的优先次序；在适当的地方实施退款制度。在我们以前的资助期间，这个核心得到了高度利用和赞赏，预计贝勒大学和休斯敦大学的研究人员将从其扩大的服务中受益。它的支持对贝勒-休斯敦CFAR的持续成功至关重要。