Clinical Core

临床核心

• 批准号: 7930106
• 负责人: John A Bartlett
• 金额: $ 27.38万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7930106
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Area; Automobile Driving; Back; Clinical; Clinical Investigator; Clinical Research; Collaborations; Communities; Databases; Development; Environment; Faculty; Funding; Good Clinical Practice; HIV; Human Subject Research; Institutes; Interdisciplinary Study; International; Laboratories; Laboratory Scientists; Link; Malignant Neoplasms; Mission; Pathogenesis; Patients; Recruitment Activity; Research; Research Personnel; Services; Site; Specimen; Translating; Universities; bench to bedside; global health; investigator-initiated translational research; novel; patient oriented research; repository; symposium

Core F The Duke University CFAR Clinical Core (Core F) provides a dynamic, higlily motivated and effective environment for HIV-related clinical studies within the Duke CFAR. In line with the overall mission for a CFAR, this Core provides "value-added" to facilitate patient-oriented research by providing clinical research expertise, regulatory support, access to patient specimens, and community involvement. The Core is responsive to the needs of the investigators within Duke and has aggressively pursued opportunities to expand clinical opportunities in Durham and through international sites. This Core has three specific aims: 1) To facilitate cutting edge patient-oriented research by clinical and laboratory investigators through the development of new Core services responsive to investigator needs and CFAR priorities such as international collaborations, and an enhanced database linked to a specimen repository; 2) To catalyze patient-oriented research collaborations between Duke CFAR investigators, especially within CFAR priority areas of HIV pathogenesis and AIDS-associated malignancies, by translating the hypotheses of Duke CFAR investigators into clinical studies, bringing novel clinical observations back to laboratory investigators, facilitating and leading interdisciplinary research teams, and actively participating in CFAR conferences and symposia; 3) To attract new investigators into patient-oriented research investigating HIV/AIDS by emphasizing interdisciplinary research efforts, communicating with key partners such as the Duke Global Health Institute and the Duke Comprehensive Cancer Institute, suggesting new collaborations, and recruiting new Duke faculty. Clinical Core accomplishments from the first four years suggest that the Clinical Core will thrive as the centerpiece of patient-oriented research within the CFAR in the next funding cycle, driving the CFAR to realize its scientific priorities.

核心F 杜克大学CFAR临床核心(CORE F)为杜克CFAR中与艾滋病毒相关的临床研究提供了一个充满活力、高度激励和有效的环境。与CFAR的总体使命一致，该核心通过提供临床研究专业知识、监管支持、患者样本获取和社区参与，提供“增值”以促进以患者为导向的研究。核心是回应杜克大学内部调查人员的需求，并积极寻求机会 在达勒姆和通过国际网站扩大临床机会。该核心有三个具体目标：1)通过开发新的核心服务，响应调查员的需求和CFAR的优先事项，如国际合作，以及与标本储存库链接的增强数据库，促进临床和实验室研究人员以患者为导向的研究；2)通过将Duke CFAR调查人员的假说转化为临床研究，将新的临床观察带回实验室研究人员，促进和领导跨学科研究团队，并积极参加CFAR会议和研讨会，促进DUKE CFAR研究人员之间面向患者的研究合作，特别是在CFAR优先领域艾滋病毒发病机制和艾滋病相关恶性肿瘤领域；3)通过强调跨学科研究努力，与杜克全球卫生研究所和杜克综合癌症研究所等关键合作伙伴沟通，建议新的合作，并招聘新的杜克教员，吸引新的研究人员进入以患者为导向的艾滋病毒/艾滋病研究。前四年的临床核心成就表明，临床核心将在下一个资金周期中蓬勃发展，成为CFAR中以患者为导向的研究的核心，推动CFAR实现其科学优先事项。