Developing Research Capacity in Africa for Studies on HIV-Associated Malignancies

描述(由申请人提供)：乞力马扎罗基督教医学中心(KCMC)和杜克大学医学中心(DUMC)将合作进一步发展艾滋病毒相关恶性肿瘤的研究能力。KCMC位于坦桑尼亚的Moshi，该地区受到艾滋病毒感染和相关并发症的严重影响，包括宫颈癌、卡波西氏肉瘤、淋巴瘤和结膜鳞状细胞癌等肿瘤。KCMC和DUMC有非常成功的现有合作，得到了NIH的慷慨支持，并参与了现有的合作研究网络。这种支持为临床研究的开展建立了强大的科学基础设施，并通过福格蒂国际中心的培训赠款得到进一步加强。这些努力的主要重点一直是艾滋病毒/艾滋病及其传染性并发症，拟议的培训和研究计划将在很大程度上建立在这些初步投资的基础上。KCMC和DUMC对扩大肿瘤学研究，特别是艾滋病毒相关恶性肿瘤的研究越来越感兴趣。然而，要实现这一目标，关键是要解决KCMC研究环境中的缺陷，这是拟议的培训计划领导力最近调查的主题。临床和实验室研究方法、病理学、放射学和研究支持人员(如肿瘤学护士、药剂师、实验室技术员和数据管理人员)方面的培训将是成功参与癌症相关研究的关键。KCMC-DUMC计划将提供精心设计的长期、中期和短期培训组合，以解决该提案中概述的具体缺陷。这些培训的地点将包括在南北和南南地点提供的正规学位和非学位实习课程的混合。在这项计划的三年时间里，共有35名调查人员和研究人员将接受培训。他们的培训经验将得到参与网络赞助和研究人员发起的艾滋病毒相关恶性肿瘤研究的机会的补充，从而将授课学习与扩大研究实践相结合。在3年结束时，KCMC-DUMC合作将准备开始一项扩大的肿瘤学研究议程。

DESCRIPTION (provided by applicant): The Kilimanjaro Christian Medical Centre (KCMC) and Duke University Medical Center (DUMC) will partner to further develop research capacity in HIV-associated malignancies. KCMC is located in Moshi, Tanzania, an area significantly impacted upon by HIV infection and associated complications, including neoplasms such as cervical cancer, Kaposi's sarcoma, lymphoma and squamous cell carcinoma of the conjunctiva. KCMC and DUMC have highly successful existing collaborations that have received generous NIH support, and participate in existing collaborative research networks. This support has created a robust scientific infrastructure for the conduct of clinical investigation, which is further enhanced with training grants from the Fogarty International Center. The major focus of these efforts has been on HIV/AIDS and its infectious complications, and the proposed training and research program will build substantially on these initial investments. There is increasing interest at KCMC and DUMC in expanding research in oncology, especially HIV-associated malignancies. However, to achieve this goal it is critical to address shortcomings in the research environment at KCMC, the subject of a recent investigation by the proposed training program leadership. Training in clinical and laboratory research methodology, pathology, radiology, and research support staff such as oncology nurses, pharmacists, laboratory technologists and data managers will be critical to engage successfully in cancer-related research. The KCMC-DUMC program will offer a carefully designed portfolio of long, medium and short-term trainings to address the specific shortcomings outlined in this proposal. The venues for these trainings will include a mix of formal degree and non-degree practicum programs, offered in North-South and South-South locations. A total of 35 investigators and research staff will be trained during the 3 years of this program. Their training experiences will be complemented by opportunities to engage in network-sponsored and investigator-initiated research into HIV-associated malignancies, thereby combining didactic learning with expanding research practices. At the completion of 3 years the KCMC-DUMC collaboration will be prepared to embark on an expanded oncology research agenda.