HIV/AIDS Clinical Trials Unit

复合材料 杜克大学医学中心(DUMC)临床试验单位(CTU)建议解决关键问题 儿童和儿童临床管理的转化研究和优化的科学领域 成人与母婴传播的预防.社区卫生服务中心及其附属临床研究 网站(CRS)带来了科学领先地位，以及成功协作临床研究的丰富历史 在网络内部，为开展严格的临床工作奠定了强大而高效的组织基础 研究和接触越来越多的未得到充分服务的艾滋病毒/艾滋病患者(PLWHA) 美国东南部和坦桑尼亚。CTU和CRS调查人员的科学领导是 反映在他们过去参加成人和儿童艾滋病临床试验小组(ACTG‘s)，以及 DUMC和乞力马扎罗基督教医疗中心不断扩大的NIH资助的研究组合 (KCMC)。CTU提案中包括的三个CRS都带来了独特的价值，并具有很高的 有动力执行拟议的工作，他们将共同构成一项强大的研究 进取号。他们的互动将由支持动态的管理结构来指导 智力环境，提高科学创造力，明确角色和责任 调查员和工作人员，便捷和定期通信，协调标准操作 通过质量管理强调CTU责任的CRS程序，以及 坚定地致力于服务于PLWHA社区。CTU和CRS组织的清晰度 运营将确保其高效运行，以最高标准进行临床研究， 能够快速响应不断变化的机遇。

Composite The Duke University Medical Center (DUMC) Clinical Trials Unit (CTU) proposes to address the key scientific areas of translational research and optimization of clinical management in children and adults, and prevention of mother to child transmission.The CTU and its affiliated Clinical Research Sites (CRS's) bring scientific leadership, a rich history of successful collaborative clinical research within networks, a strong and efficient organizational foundation for the conduct of rigorous clinical research, and access to growing numbers of underserved persons living with HIV/AIDS (PLWHA) in the US Southeast and Tanzania. The scientific leadership of the CTU and CRS investigators is reflected in their past participation in the Adult and Pediatric AIDS Clinical Trials Groups (ACTG's), and the expanding portfolio of NIH-funded research at DUMC and the Kilimanjaro Christian Medical Centre (KCMC). The three CRS's included in the CTU proposal each bring unique value and are highly motivated to perform the proposed work, and together they will constitute a formidable research enterprise. Their interactions will be guided by an administrative structure which supports a dynamic intellectual environment to enhance scientific creativity, clear roles and responsibilities for investigators and staff, facile and regular communications, harmonized standard operating procedures across CRS's which emphasize CTU accountability through quality management, and a strong commitment to serve the community of PLWHA. The clarity of CTU and CRS organization and operations will ensure that it operates efficiently to perform clinical research at the highest standard, with the ability to rapidly respond to evolving opportunities.