Aging Rodent Core

老化啮齿动物核心：Evan Keller，主任 老化啮齿动物核心（ARC）的中心目的是促进使用突变和转基因啮齿动物进行衰老的细胞和分子生物学研究以及衰老过程与晚年疾病的关系。ARC将通过三项相互关联的举措实现其目标。(1)ARC将为希望生产老年小鼠的研究者支付每日费用，通常是突变或转基因或敲除小鼠，这些小鼠在老年时无法获得。(2)ARC将与由Sally Camper和Thom Saunders指导的UM转基因动物模型设施（TAMF）合作，协助休克中心的研究人员， 支付TAMF服务所需的准备新的转基因或基因敲除小鼠（和大鼠）的工作，在乳腺癌。(3)ARC将促进将组织病理学纳入这些项目，为涉及国家科学委员会研究人员生产老年小鼠的选定项目（大约每年2个）提供切片制备费用补贴。 在所有这些努力中，ARC主任将为希望使用老年啮齿动物进行研究的UM教职员工提供有关方案设计和选择适当动物模型的建议。

Aging Rodent Core: Evan Keller, Director The central purpose of the Aging Rodent Core (ARC) is to promote the use of mutant and transgenic rodents for investigations of the cellular and molecular biology of aging and the relationship of the aging process to late life disease. The ARC will accomplish its goals through three inter-related initiatives. (1) ARC will pay for per diem costs for investigators who wish to produce aged mice, typically of mutant or transgenic or knockout stocks, that are not otherwise available at older ages. (2) ARC will work with the UM Transgenic Animal Model Facility (TAMF), directed by Sally Camper and Thom Saunders, to assist Shock Center investigators to pay for TAMF services needed to prepare new transgenic or KO mice (and rats) for work in biogerontology. (3) ARC will promote the incorporation of histopathology in such projects by subsidizing the costs of slide preparation for selected projects (roughly 2/year) involving the production of aged mice by NSC researchers. In all these efforts, the ARC Director will provide advice on protocol design and selection of appropriate animal models to UM faculty members who wish to use aged rodents for their studies.