Aging Rodent Core

老化啮齿动物核心

• 批准号: 8122845
• 负责人: Evan T Keller
• 金额: $ 9.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122845
• 关键词: Age; Aging; Aging-Related Process; Animal Model; Biology of Aging; Disease; Elderly; Faculty; Gerontology; Goals; Histopathology; Investigation; Knock-out; Molecular Biology; Mus; Preparation; Production; Protocols documentation; Rattus; Research Personnel; Rodent; Services; Shock; Slide; Transgenic Animals; Transgenic Organisms; Work; aged; cost; design; member; mutant

Aging Rodent Core: Evan Keller, Director The central purpose of the Aging Rodent Core (ARC) is to promote the use of mutant and transgenic rodents for investigations of the cellular and molecular biology of aging and the relationship of the aging process to late life disease. The ARC will accomplish its goals through three inter-related initiatives. (1) ARC will pay for per diem costs for investigators who wish to produce aged mice, typically of mutant or transgenic or knockout stocks, that are not otherwise available at older ages. (2) ARC will work with the UM Transgenic Animal Model Facility (TAMF), directed by Sally Camper and Thom Saunders, to assist Shock Center investigators to pay for TAMF services needed to prepare new transgenic or KO mice (and rats) for work in biogerontology. (3) ARC will promote the incorporation of histopathology in such projects by subsidizing the costs of slide preparation for selected projects (roughly 2/year) involving the production of aged mice by NSC researchers. In all these efforts, the ARC Director will provide advice on protocol design and selection of appropriate animal models to UM faculty members who wish to use aged rodents for their studies.

老化的啮齿动物核心：主任埃文·凯勒 老龄啮齿动物核心(ARC)的中心目的是促进利用突变和转基因啮齿动物来研究衰老的细胞和分子生物学以及衰老过程与老年疾病的关系。ARC将通过三个相互关联的倡议来实现其目标。(1)ARC将为希望培育老年小鼠的研究人员支付每日费用，这些小鼠通常是突变、转基因或基因敲除小鼠，而这些小鼠在老年时是无法获得的。(2)ARC将与由Sally Camper和Thom Saunders领导的UM转基因动物模型设施(TAMF)合作，协助休克中心调查人员 支付为生物老年学工作准备新的转基因或KO小鼠(和大鼠)所需的TAMF服务。(3)研究局将透过资助选定项目(每年约2份)的载玻片制作费用(约为2份/年)，以促进将组织病理学纳入这些项目，而该项目涉及国家科学委员会研究人员生产老龄小鼠。在所有这些努力中，ARC主任将为希望使用老年啮齿动物进行研究的UM教员提供方案设计和选择适当动物模型的建议。