Functional Assessment Core

功能评估核心：Greg Cartee，总监 功能评估核心（FAC）将促进UM丰富的生物医学研究核心实验室的有效利用，用于衰老的细胞生物学，生理学和分子生物学研究。 理由和目标：密歇根大学拥有各种各样的设备齐全的研究支持核心，每个核心都由经验丰富的教师监督，并雇用高技能的技术人员，通过提供超出任何一个实验室小组范围的资源，促进多个学科的生物医学科学。这些核心通常由大学补贴，每个核心都对其服务收取UM认证的充值费率。在UM校园内提供的50多个这样的核心实验室中，有几个对休克中心的科学家来说特别有价值。其中包括Affyoung和Microarray 核心，动物表型核心实验室，生物医学质谱设施，整合基因组学中心，分子成像中心，DNA测序核心，流式细胞术核心，杂交核心，代谢组学核心，显微镜和图像分析实验室，新的shRNA文库核心和病毒载体核心。而不是试图复制或与任何这些一流的专业团体竞争，FAC将与UM神经生物学家合作开发项目，使一个或多个这些UM核心的最佳利用，然后支付40%的费用为FAC批准的项目。 该系统不同于其他一些内森休克中心的“功能评估核心”所使用的系统。 在不隶属于主要学术医疗中心的NSC，很可能有必要使用NSC的资金建立专门的核心设施，以满足研究目标，否则无法解决。 然而，在像UM这样的大型研究中心，面临的挑战不是从头开始开发这样的核心设施，而是促进使用这些完善的设施来支持人类学研究。通过为NSC教师提供协议开发和核心资源方面的指导，并帮助支付选定项目使用UM核心设施的费用，FAC将利用其有限的资金来支持具有特殊价值和与衰老生物学高度相关性的研究。

Functional Assessment Core: Greg Cartee, Director The Functional Assessment Core (FAC) will promote the effective use of UM's rich set of Biomedical Research Core laboratories for studies in the cell biology, physiology, and molecular biology of aging. Rationale and goals: The University of Michigan has an exceptionally diverse range of well equipped research support cores, each supervised by experienced faculty members and employing highly skilled technicians, which facilitate biomedical science in multiple disciplines by providing resources beyond the reach of any one laboratory group. These Cores are in general subsidized by the University, and each charges a UM-certified recharge rate for its services. Of the more than fifty such Core Labs available on the UM campus, several are particularly likely to be valuable for Shock Center scientists. These include the Affymetrix and Microarray Core, the Animal Phenotyping Core Laboratory, the Biomedical Mass Spectrometry Facility, the Center for Integrative Genomics, the Center for Molecular Imaging, the DNA Sequencing Core, the Flow Cytometry Core, the Hybridoma Core, the Metabolomics Core, the Microscopy and Image Analysis Laboratory, the new shRNA Library Core, and the Viral Vector Core. Rather than attempt to duplicate or compete with any of these superb specialty groups, the FAC will work with UM biogerontologists to develop projects that make optimal use of one or more of these UM Cores, and then pay for 40% of the costs for FAC-approved projects. This system differs from that used by "Functional Assessment Cores" at some other Nathan Shock Centers. At NSCs that are not affiliated with major academic medical centers, it may well be necessary to use NSC funds to set up specialized core facilities to meet research objectives that could not otherwise be addressed. At larger research centers like UM, however, the challenge is not to develop such Core facilities from scratch, but rather to promote the use of these well-established facilities in support of biogerontological research. By providing guidance to NSC faculty on protocol development and Core resources, and by helping to pay for the costs of use of the UM Core facilities for selected projects, the FAC will leverage its limited funds to support research of special value and high relevance to the biology of aging.