Functional Assessment Core

功能评估核心：格雷格·卡蒂，主管 功能评估核心(FAC)将促进有效利用密歇根大学丰富的生物医学研究核心实验室来研究衰老的细胞生物学、生理学和分子生物学。 基本原理和目标：密歇根大学拥有一系列设备齐全的研究支持中心，每个中心都由经验丰富的教职员工监督，并雇用高技能的技术人员，通过提供任何一个实验室小组无法提供的资源，促进多学科的生物医学科学。这些核心通常由大学补贴，每个核心对其服务收取UM认证的充值率。在密歇根大学园区提供的50多个这样的核心实验室中，有几个特别可能对休克中心的科学家有价值。其中包括Affymetrix和微阵列 核心、动物表型核心实验室、生物医学质谱仪、综合基因组学中心、分子成像中心、DNA测序核心、流式细胞术核心、杂交瘤核心、代谢组学核心、显微镜和图像分析实验室、新的shRNA文库核心和病毒载体核心。FAC将与UM生物老年病学家合作开发最佳利用一个或多个UM核心的项目，然后为FAC批准的项目支付40%的成本，而不是试图复制这些优秀的专业团体或与任何一个优秀的专业团体竞争。 该系统不同于其他一些内森休克中心的“功能评估核心”所使用的系统。在没有附属于主要学术医疗中心的NSC，很可能有必要使用NSC资金来建立专门的核心设施，以满足其他方式无法解决的研究目标。然而，在像UM这样的大型研究中心，挑战不是从头开始开发这样的核心设施，而是促进这些成熟设施的使用，以支持生物老年学研究。通过向NSC教员提供礼仪开发和核心资源方面的指导，并通过帮助支付UM核心设施用于选定项目的费用，FAC将利用其有限的资金支持与衰老生物学具有特殊价值和高度相关性的研究。

Functional Assessment Core: Greg Cartee, Director The Functional Assessment Core (FAC) will promote the effective use of UM's rich set of Biomedical Research Core laboratories for studies in the cell biology, physiology, and molecular biology of aging. Rationale and goals: The University of Michigan has an exceptionally diverse range of well equipped research support cores, each supervised by experienced faculty members and employing highly skilled technicians, which facilitate biomedical science in multiple disciplines by providing resources beyond the reach of any one laboratory group. These Cores are in general subsidized by the University, and each charges a UM-certified recharge rate for its services. Of the more than fifty such Core Labs available on the UM campus, several are particularly likely to be valuable for Shock Center scientists. These include the Affymetrix and Microarray Core, the Animal Phenotyping Core Laboratory, the Biomedical Mass Spectrometry Facility, the Center for Integrative Genomics, the Center for Molecular Imaging, the DNA Sequencing Core, the Flow Cytometry Core, the Hybridoma Core, the Metabolomics Core, the Microscopy and Image Analysis Laboratory, the new shRNA Library Core, and the Viral Vector Core. Rather than attempt to duplicate or compete with any of these superb specialty groups, the FAC will work with UM biogerontologists to develop projects that make optimal use of one or more of these UM Cores, and then pay for 40% of the costs for FAC-approved projects. This system differs from that used by "Functional Assessment Cores" at some other Nathan Shock Centers. At NSCs that are not affiliated with major academic medical centers, it may well be necessary to use NSC funds to set up specialized core facilities to meet research objectives that could not otherwise be addressed. At larger research centers like UM, however, the challenge is not to develop such Core facilities from scratch, but rather to promote the use of these well-established facilities in support of biogerontological research. By providing guidance to NSC faculty on protocol development and Core resources, and by helping to pay for the costs of use of the UM Core facilities for selected projects, the FAC will leverage its limited funds to support research of special value and high relevance to the biology of aging.