NEURAL BASIS OF RESILIENT READERS IN DYSLEXIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 简介： 直到最近，人们才发现一些有阅读障碍的读者可能会被归类为“弹性读者”，因为他们的平均水平或高于平均水平的文本理解能力。 具体目标： 为了研究弹性读者的神经基础， 研究方法： 共有62名6-16岁（平均13.4岁，标准差（SD）2.6）的健康母语为英语的人参加了我们的研究。 其中，31名儿童是熟练的读者和31名有和没有穷人的阅读理解能力（15和16名儿童，分别）的阅读障碍。我们进行了基于体素的形态测量（VBM），并检查了区域灰色和白色物质体积（GMV，WMV）的差异，在有和没有不良的阅读理解障碍的青少年。 我们还进行了语音和语义处理任务，利用功能磁共振成像（fMRI），以确定是否有相应的大脑激活的差异。 结果如下： 全脑GMV分析回归总GMV显示，与Dys[PoorComp]组相比，Dys[NormComp]组左侧顶颞区的GMV显著更大（p<0.01校正）。该簇包括左后上级颞回（pSTG）和顶下小叶（IPL）中的两个不同的峰。WMV无显著差异。事后感兴趣区域分析显示，与Dys[NormComp]和Dys[PoorComp]组合相比，对照组的GMV显著更大（t（59）=2.09，p=0.04），但与仅Dys[NormComp]相比则没有显著性差异（t（59）=0.72，p=0.48）。 与认知特征相对应的是，Dys[NormComp]和Dys[PoorComp]在押韵判断时的左侧顶颞区激活没有显著差异，但Dys[NormComp]在语义分类时的激活显著高于Dys[PoorComp]。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Only recently has it been explored that some dyslexic readers may classify as 'resilient readers' because of their average or above average text comprehension skills. Specific Aims: To investigate the neural basis of resilient readers, Methods: A total of 62 healthy native English speakers between 6-16 years of age (mean 13.4, standard deviation (SD) 2.6) participated in our study. Among them, 31 children were skilled readers and 31 were dyslexic readers with and without poor reading comprehension skills (15 and 16 children, respectively). We performed voxel-based morphometry (VBM) and examined differences in regional gray and white matter volume (GMV, WMV) in dyslexic adolescents with and without poor reading comprehension. We also performed phonological and semantic processing tasks utilizing functional magnetic resonance imaging (fMRI) to identify whether there were corresponding differences in brain activation. Results: Whole brain analysis of GMV regressing out total GMV showed significantly greater GMV in the left parieto-temporal region in the Dys[NormComp] compared to the Dys[PoorComp] Group (p<0.01 corrected). This cluster included two distinct peaks in the left posterior superior temporal gyrus (pSTG) and inferior parietal lobule (IPL). There were no significant differences in WMV. Post-hoc region-of-interest analysis showed significantly greater GMV in controls compared to Dys[NormComp] and Dys[PoorComp] combined (t(59)=2.09, p=0.04), but not compared to Dys[NormComp] only (t(59)=0.72, p=0.48). Corresponding to the cognitive characteristics, left parieto-temporal activation during rhyme judgment showed no significant difference between Dys[NormComp] and Dys[PoorComp], but Dys[NormComp] compared to Dys[PoorComp] showed significantly greater activation during semantic categorization in this region.