NEURAL BASIS OF RESILIENT READERS IN DYSLEXIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 直到最近才有研究发现，一些阅读困难的读者可能会因为他们的文本理解能力一般或高于平均水平而被归类为“弹性读者”。 具体目标： 为了研究弹性读者的神经基础， 方法： 研究对象为62名健康的英语母语者，年龄在6-16岁之间(平均13.4岁，标准差2.6)。其中，阅读技能熟练的儿童31名，阅读理解能力差的儿童31名(分别为15名和16名)。我们进行了基于体素的形态测量(VBM)，并检测了阅读理解不良的阅读障碍青少年和非阅读理解不良的阅读障碍青少年在局部灰质和白质体积(GMV，WMV)上的差异。我们还利用功能磁共振成像(FMRI)进行了语音和语义处理任务，以确定大脑激活是否存在相应的差异。 结果： 全脑GMV回归分析显示，Dys[NormComp]组左侧顶颞区GMV显著高于Dys[PoorComp]组(p&lt；0.01校正)。该簇包括位于左侧后颞叶上回(PSTG)和顶下小叶(IPL)的两个不同的峰。WMV差异无统计学意义。特殊后感兴趣区分析显示，对照组的GMV显著高于Dys[NormComp]和Dys[PoorComp]的总和(t(59)=2.09，p=0.04)，但与仅Dys[NormComp]相比(t(59)=0.72，p=0.48)。 与认知特征相对应，Dys[NormComp]和Dys[PoorComp]在押韵判断中的左顶时激活无显著差异，但在该区域的语义范类加工中，Dys[NormComp]的激活显著高于Dys[PoorComp]。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Only recently has it been explored that some dyslexic readers may classify as 'resilient readers' because of their average or above average text comprehension skills. Specific Aims: To investigate the neural basis of resilient readers, Methods: A total of 62 healthy native English speakers between 6-16 years of age (mean 13.4, standard deviation (SD) 2.6) participated in our study. Among them, 31 children were skilled readers and 31 were dyslexic readers with and without poor reading comprehension skills (15 and 16 children, respectively). We performed voxel-based morphometry (VBM) and examined differences in regional gray and white matter volume (GMV, WMV) in dyslexic adolescents with and without poor reading comprehension. We also performed phonological and semantic processing tasks utilizing functional magnetic resonance imaging (fMRI) to identify whether there were corresponding differences in brain activation. Results: Whole brain analysis of GMV regressing out total GMV showed significantly greater GMV in the left parieto-temporal region in the Dys[NormComp] compared to the Dys[PoorComp] Group (p<0.01 corrected). This cluster included two distinct peaks in the left posterior superior temporal gyrus (pSTG) and inferior parietal lobule (IPL). There were no significant differences in WMV. Post-hoc region-of-interest analysis showed significantly greater GMV in controls compared to Dys[NormComp] and Dys[PoorComp] combined (t(59)=2.09, p=0.04), but not compared to Dys[NormComp] only (t(59)=0.72, p=0.48). Corresponding to the cognitive characteristics, left parieto-temporal activation during rhyme judgment showed no significant difference between Dys[NormComp] and Dys[PoorComp], but Dys[NormComp] compared to Dys[PoorComp] showed significantly greater activation during semantic categorization in this region.