ENHANCED BOLD RESPONSE IN BREAST TUMORS INDUCED BY BREATH HOLDING

增强对屏气诱发的乳腺癌的大胆反应

• 批准号: 8169823
• 负责人: Rebecca Rakow
• 金额: $ 4.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169823
• 关键词: Affinity; Age; Blood Circulation; Breast; Breathing; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Data Analyses; Diagnostic; Fatty acid glycerol esters; Functional Magnetic Resonance Imaging; Funding; Grant; Human Resources; Hypoxia; Image; Institution; Malignant - descriptor; Mammary Gland Parenchyma; Mammary Neoplasms; Measures; Methods; Oxygen; Participant; Patients; Perfusion; Pharmacologic Substance; Physiologic pulse; Physiology; Procedures; Property; Protocols documentation; Qualifying; Research; Research Personnel; Resources; Scanning; Source; Time; Tissues; Twin Multiple Birth; United States National Institutes of Health; Variant; blood oxygenation level dependent response; healthy volunteer; hemodynamics; intravenous injection; malignant breast neoplasm; response; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Current protocols for tumor imaging, specifically applied with breast cancer candidates, call for the use of pharmaceutical contrast agents. These agents require intravenous injection causing additional discomfort to the patient while also requiring qualified personnel to start the IV. An alternative that allows for a totally non-invasive procedure, by simply exploiting the innate physiology of tumors, is ideal. A defining property of tumors is their high affinity for oxygen, causing regionally altered perfusion characteristics. BOLD imaging, most commonly used in fMRI studies, measures the hemodynamic variation in a given region resulting from a stimulating task. Simple breath holding, which induces hypoxia, shows an increased BOLD response in fMRI studies due to variation of the oxygen levels in the bloodstream. This study demonstrates the BOLD response in the breast resulting from periodic hypoxia, and its promise in differentiating tumors from other breast tissue. The scan protocol used a 3D ¿stack of spirals¿ imaging sequence with a spectral-spatial pulse for fat suppression. Two healthy volunteers (both age 24) and one breast tumor patient (age 36) participated in the study. The healthy volunteers were scanned on a 1.5T Signa GE scanner, while the patient was scanned on a 1.5T Twin GE scanner. Each participant held their breath for 15 s intervals followed by 15 s of regular breathing, for 7 cycles. Data analysis of BOLD results applied a time course correlation method established by Adrian Lee et al. The method correlates the breath holding cycle to sinusoidal functions. Malignant regions present in Gd enhanced images paralleled regions observed in early response BOLD images stimulated by hypoxia. As expected, carcinogenic regions responded earlier than healthy regions under hypoxic conditions, with results indicating a 7.5 s time delay between the malignant verses healthy tissue. This study demonstrates how BOLD images can identify tumor regions without contrast agents, with the potential of providing additional diagnostic information.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 肿瘤成像的当前方案，专门用于乳腺癌候选物，要求使用药物对比剂。这些药物需要静脉注射，从而给患者带来额外的不适，同时还要求合格的人员开始IV。仅通过简单地利用肿瘤的先天生理学，一种允许完全非侵入性程序的替代方法是理想的选择。肿瘤的定义特性是它们对氧气的高亲和力，导致区域改变灌注特征。 大胆的成像是在功能磁共振成像研究中最常用的，它测量了由刺激任务引起的给定区域中的血液动力学变化。诱发缺氧的简单呼吸持有，由于血液中氧气水平的变化，在fMRI研究中显示出大胆的反应。这项研究表明，周期性缺氧导致乳房的大胆反应及其在区分肿瘤与其他乳腺组织的承诺。 扫描协议使用了3D•螺旋层堆放的成像序列，具有光谱空间脉冲以抑制脂肪。这项研究参与了两名健康志愿者（24岁）和一名乳腺肿瘤患者（36岁）。将健康的志愿者扫描在1.5T的签名扫描仪上，而患者则在1.5吨的双GE扫描仪上进行扫描。每个参与者的呼吸间隔15 s，然后进行15 s的常规呼吸，进行7个周期。 BOLD结果的数据分析应用了Adrian Lee等人建立的时间课程相关方法。该方法将呼吸周期与正弦函数相关联。 GD增强图像中存在的恶性区域与缺氧刺激的早期反应大胆图像中观察到的平行区域。如预期的那样，在低氧条件下，致癌区比健康区域早反应，结果表明恶性经文之间的时间延迟为7.5 s。这项研究表明，大胆的图像如何在没有对比剂的情况下识别肿瘤区域，并有可能提供其他诊断信息。